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557 articles
September 202624
Rotational thromboelastometry guided transfusion in venom-induced consumptive coagulopathy following a haemotoxic snakebite.
A woman in her 30s presented with severe haemotoxic snake envenoming and venom-induced consumptive coagulopathy (VICC), leading to early multiorgan involvement.
Scleromyxedema-Associated Myopathy and Vacuolar Myopathy with Monoclonal Gammopathy and Stiffness (VAMMGAS) as manifestations of Monoclonal Gammopathy of Clinical Significance (MGCS): a disease spectrum between autophagy dysfunction and inflammation.
This report discusses two patients with Scleromyxedema-Associated Myopathy (SAM) and one with Vacuolar Myopathy with Monoclonal Gammopathy and Stiffness (VAMMGAS), both associated with Monoclonal Gammopathy of Clinical…
Refractory Acquired Thrombotic Thrombocytopenic Purpura in the Third Trimester of Twin Pregnancy: A Case Report.
A 29-year-old woman in her third trimester of a twin pregnancy presented with symptoms including palpitations, dyspnea, and oral bleeding, alongside severe thrombocytopenia.
Genomic evidence implicates patient-room showers in Mycobacterium llatzerense bacteremia among two cord blood transplant recipients.
Two cord blood transplant recipients developed persistent fever despite broad-spectrum therapy, with blood cultures eventually growing acid-fast bacilli. Sequencing identified Mycobacterium llatzerense.
Autologous Hematopoietic Transplantation Reduces Brain Inflammatory and Axoglial Damage Biomarkers in Multiple Sclerosis.
This Phase II multicenter clinical trial investigated the effects of autologous hematopoietic stem cell transplantation (AHSCT) on inflammatory and axoglial damage biomarkers in 24 patients with severe multiple…
Impact of resolved hepatitis B virus infection on clinical outcomes in patients with diffuse large B-cell lymphoma: a supplementary analysis of JCOG0601.
This supplementary analysis of the randomized JCOG0601 phase II/III trial examined whether resolved hepatitis B virus infection was associated with outcomes in patients with previously untreated, HBsAg-negative diffuse…
Carfilzomib plus induction chemotherapy for children with relapsed or refractory acute lymphoblastic leukemia.
This phase II clinical trial evaluated the efficacy of carfilzomib combined with induction chemotherapy (CFZ-VXLD) in pediatric patients aged 1 month to <21 years with relapsed or refractory acute lymphoblastic leukemia…
Atypical Bullous Sweet Syndrome.
A 71-year-old male with acute myeloid leukemia presented with bullous Sweet syndrome after receiving pegfilgrastim and quizartinib.
Factor V Deficiency and Mechanical Valve Replacement: Challenges in Perioperative Hemostasis and Anticoagulation.
A 30-year-old woman with congenital factor V deficiency (baseline activity 18%) underwent mechanical aortic valve replacement and mitral valve repair due to infective endocarditis.
When A Fall Isn't Just a Fall: Delayed Diagnosis of Acquired Hemophilia A in a Nonagenarian Patient.
A 92-year-old woman presented with severe right lower extremity pain after recurrent ground-level falls. Imaging revealed bilateral lower extremity intramuscular hematomas.
ATM mutations in myelodysplastic neoplasms, acute myeloid leukemia, and myeloproliferative neoplasms: a systematic review.
This systematic review evaluated the impact of ATM mutations in myelodysplastic neoplasms (MDS), acute myeloid leukemia (AML), and myeloproliferative neoplasms (MPN).
Vision loss as the first manifestation of isolated cns relapse in CML blast crisis during flumatinib maintenance therapy: A case report.
A 65-year-old male with chronic myeloid leukemia in complete remission presented with progressive vision loss, indicating isolated CNS relapse.
Electronic patient-reported outcome platforms used in hematological cancers: a systematic review.
This systematic review examined electronic patient-reported outcome measures (ePROMs) in hematological cancers, identifying 14 platforms from 18 studies.
First reported human Castellaniella defragrans bacteraemia: a case report.
An 82-year-old man with monoclonal B-cell lymphocytosis, later diagnosed with chronic lymphocytic leukaemia, presented with fever, confusion, and signs of sepsis.
Iberdomide plus daratumumab and dexamethasone versus daratumumab, bortezomib, and dexamethasone in patients with relapsed or refractory multiple myeloma (EXCALIBER-RRMM): an open-label, randomised, controlled, phase 3 trial.
EXCALIBER-RRMM is an ongoing, open-label, randomised phase 3 trial comparing iberdomide, daratumumab, and dexamethasone with daratumumab, bortezomib, and dexamethasone in adults with relapsed or refractory multiple…
Recurrent VTE in patients with thrombophilia after stopping anticoagulation: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the risk of recurrent venous thromboembolism (VTE) after stopping anticoagulation in patients with hereditary and acquired thrombophilia.
Etuvetidigene Autotemcel for the Treatment of Wiskott-Aldrich Syndrome.
This multicenter clinical trial evaluated the safety and efficacy of etuvetidigene autotemcel (etu-cel) in patients with Wiskott-Aldrich syndrome, integrating data from two studies and an expanded-access program.
Phase 1 Study of Anito-cel, a d-Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma.
This phase 1 multicenter study evaluated the safety and efficacy of anitocabtagene autoleucel (anito-cel), a BCMA-directed CAR T-cell therapy, in 40 patients with relapsed or refractory multiple myeloma.
Immune Thrombotic Thrombocytopenic Purpura: Diagnosis and Management.
A middle-aged patient with a history of immune-mediated thrombotic thrombocytopenic purpura (iTTP) presented with a relapse characterized by thrombocytopenia and microangiopathic hemolytic anemia.
Classic mantle cell lymphoma with aberrant immunohistochemical expression of Fc receptor-like 4/immunoglobulin superfamily receptor translocation-associated 1.
A patient diagnosed with classic mantle cell lymphoma (MCL) presented with typical clinical, morphologic, immunophenotypic, and genetic features.
Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews.
This systematic review and meta-analysis evaluated the efficacy of red blood cell (RBC) transfusions in treating or preventing complications in sickle cell disease (SCD) across 17 Cochrane reviews.
Expanded antigen-specific donor regulatory T cells for GVHD prevention.
This phase 1 clinical trial evaluated the safety and preliminary efficacy of expanded minor histocompatibility antigen (mHAg)-specific donor regulatory T cells (Treg) for preventing graft-versus-host disease (GVHD) in…
Venetoclax plus pediatric regimen in adolescents and adults with Ph-negative acute lymphoblastic leukemia.
This phase II multicenter trial evaluated the efficacy of venetoclax combined with pediatric-inspired chemotherapy in 167 adolescents and adults with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic…
Population pharmacokinetic analysis of pirtobrutinib, a non-covalent BTK inhibitor, in patients with hematological malignancies from the Phase 1/2 BRUIN study.
This population pharmacokinetic analysis evaluated pirtobrutinib, a non-covalent BTK inhibitor, in 595 patients with hematological malignancies from the Phase 1/2 BRUIN study.
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