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2000 articles
June 202624
SACI-IO HR+: a randomized phase II trial of sacituzumab govitecan with or without pembrolizumab in patients with metastatic hormone receptor-positive/HER2-negative breast cancer.
This randomized phase II trial evaluated the efficacy of sacituzumab govitecan (SG) with or without pembrolizumab in patients with metastatic hormone receptor-positive/HER2-negative breast cancer.
Computed tomography derived body composition and risk of anastomotic leakage following rectal cancer surgery: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the association between computed tomography (CT)-derived body composition metrics and anastomotic leakage (AL) risk in 5763 rectal cancer patients undergoing…
Metachronous multiple insulinomas in oculo-facio-cardio-dental syndrome harboring a novel BCOR deletion: a case report with review of literature.
A female patient with genetically confirmed oculo-facio-cardio-dental (OFCD) syndrome, due to a novel BCOR deletion, presented with recurrent hypoglycemic episodes.
Quality of Life Endpoints in Advanced Gastrointestinal Cancer Trials: Systematic Review of Inclusion, Challenges, and Implications (2020-2024).
This systematic review examined the inclusion of quality of life (QoL) endpoints in 80 phase III clinical trials for advanced gastrointestinal cancers.
Efficacy and safety of darolutamide plus androgen-deprivation therapy in Black patients with metastatic hormone-sensitive prostate cancer from the phase 3 ARANOTE trial.
The ARANOTE phase 3 trial analyzed the efficacy and safety of darolutamide plus androgen-deprivation therapy (ADT) specifically in Black patients with metastatic hormone-sensitive prostate cancer.
Targeting ncRNA control networks with engineered exosomes to overcome therapy resistance in thyroid cancer.
This systematic review evaluated the role of exosomal non-coding RNAs (ncRNAs) in therapy resistance in radioactive iodine-refractory papillary thyroid cancer (RAIR-PTC).
Cytological Features of Clear Cell Sarcoma in Exfoliative and Effusion Cytology Specimen-A Case Report and Literature Review.
A patient with metastatic clear cell sarcoma of soft tissue presented with malignant effusions in sputum, peritoneal fluid, and pericardial fluid.
Somatic BRCA1 and BRCA2 detection in homologous recombination deficiency testing: concordance of four sequencing workflows with the Myriad myChoice companion diagnostic.
This multicenter study assessed agreement between four tumor sequencing workflows and the Myriad myChoice companion diagnostic for BRCA1/BRCA2 variant detection in newly diagnosed ovarian cancer.
The prognostic value of tumour budding for survival in stage II and III colorectal cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed whether high-grade tumour budding (TB) predicts survival in stage II and III colorectal cancer.
Intermittent olaparib with neoadjuvant platinum-based chemotherapy in BRCA-mutated un-resectable ovarian cancer: the NUVOLA trial.
The NUVOLA trial, a phase II open-label study, evaluated the addition of olaparib to neoadjuvant chemotherapy in 36 patients with BRCA-mutated advanced epithelial ovarian cancer.
Assessing the performance of deep learning and hand-crafted radiomics models using MRI and ultrasound in predicting axillary lymph node status in breast cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed deep learning (DL) and hand-crafted radiomics (HCR) models using MRI or ultrasound to predict axillary lymph node metastasis in breast cancer, with histopathology as the…
Single-Port Robotic Cytoreductive Surgery for Colon Cancer Peritoneal Recurrence with the da Vinci SP.
A 61-year-old female with colon cancer developed ovarian and peritoneal metastases 14 months post-laparoscopic right hemicolectomy.
Cytologic Detection of Metastatic Immature Teratomas in Two Young Patients With Unique Presentations.
Two young women presented with high-grade ovarian immature teratomas featuring metastatic immature neuroepithelial components.
Fraction-dependent dose dynamics and clinical safety in high-risk neuroblastoma treated with [ 177 Lu]Lu-DOTATATE: results from the LuDO-N trial.
The LuDO-N trial evaluated the safety and dosimetry of a two-fraction regimen of [177Lu]Lu-DOTATATE in 14 patients with high-risk neuroblastoma.
Lutetium-177-PSMA I&T (Lu-PSMA) with radiosensitising capecitabine in patients with metastatic castration-resistant prostate cancer (mCRPC): results of phase Ia study.
This phase I trial evaluated the safety and maximum tolerated dose (MTD) of capecitabine combined with Lutetium-177-PSMA I&T (Lu-PSMA) in 12 men with metastatic castration-resistant prostate cancer (mCRPC).
Hilar lymph node involvement in pediatric liver cancer and its impact on outcomes: A systematic review.
This systematic review evaluated hilar lymph node involvement in pediatric liver cancer, analyzing data from eight studies involving 880 patients.
Diffuse Splenic Uptake on 99m Tc MDP Bone Scintigraphy Secondary to Transfusion-Related Hemosiderosis : Correlation With MRI Findings.
A 70-year-old woman with a past medical history of breast cancer is undergoing surveillance. She also had a history of repeated blood transfusions for refractory anemia caused by treated marrow metastatic disease.
Impact of Surgical Delay on Breast Cancer Prognosis: Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the impact of surgical delays on survival in invasive breast cancer, analyzing data from 26 studies with 4,921,120 patients.
The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta-Analysis of the European Myeloma Network (EMN).
This systematic review and network meta-analysis evaluated maintenance therapies for newly diagnosed multiple myeloma. It found that lenalidomide, proteasome inhibitors, and CD38 antibodies improved progression-free…
Bridging the Gap from "Paper" to "Patient": An Overview and Quality Assessment of PET/CT-Based Radiomics for Prostate Cancer Using the Updated RQS 2.0.
This systematic review evaluated the methodological quality and clinical translation maturity of PET-based radiomics studies in prostate cancer using the updated Radiomics Quality Score (RQS 2.0).
Antidiabetic medications and the risk of bladder cancer in patients with diabetes mellitus: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the association between antidiabetic medications and bladder cancer risk in patients with type 2 diabetes mellitus. A total of 85 studies were included.
Performance of Survival Prediction Tools in Patients With Gastrointestinal Stromal Tumors: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated survival prediction tools for adults with primary gastrointestinal stromal tumors (GISTs), analyzing 47 studies.
Prognosis of ER-positive, HER2-negative postmenopausal early breast cancer patients based on response to neoadjuvant endocrine therapy and multigene assay results: findings from the NEOS trial.
This phase III clinical trial investigated the long-term prognosis of 226 postmenopausal women with ER-positive, HER2-negative early breast cancer based on their response to neoadjuvant endocrine therapy and multigene…
Limb Compression Therapy and Chemotherapy-Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self-Controlled Study(NEURO-GLOVE Trial).
This prospective, self-controlled study evaluated the effect of dual-site mechanical compression on chemotherapy-induced peripheral neuropathy (CIPN) in 76 women with gynecologic cancers receiving…
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