Efficacy and safety of darolutamide plus androgen-deprivation therapy in Black patients with metastatic hormone-sensitive prostate cancer from the phase 3 ARANOTE trial.

Prostate Cancer Prostatic DisJun 20, 2026 (epub)
Clinical ResearchOncology (Medical)Open access

Quoc-Dien Trinh, Daniel J George, Neal Shore et al.

✦ AI-curated · Sources linked

In 30 seconds

The ARANOTE phase 3 trial analyzed the efficacy and safety of darolutamide plus androgen-deprivation therapy (ADT) specifically in Black patients with metastatic hormone-sensitive prostate cancer. Among 65 Black patients, darolutamide combined with ADT significantly improved radiological progression-free survival (rPFS), reducing the risk of radiological progression or death by 49% compared to ADT alone.

Key findings

  • Darolutamide plus ADT reduced the risk of radiological progression or death by 49% compared to ADT alone.
  • The study included 65 Black patients, representing 10% of the total ARANOTE population.
  • Patients received darolutamide 600 mg twice daily or placebo in a 2:1 randomization.

Why it matters

This study highlights the potential benefits of darolutamide in improving treatment outcomes for Black patients with metastatic hormone-sensitive prostate cancer, a population that may experience disparities in care.

Source

PubMed · PMID 42323390Free full text on PubMed Central

Published in Prostate Cancer Prostatic Dis. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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