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557 articles
October 202615
Toxin-induced coagulopathy following a MacMahon viper bite.
A patient presented with a MacMahon viper bite, experiencing significant local envenomation, hypotension, and syncope. Laboratory tests showed rapid thrombocytopenia and impaired haemostatic function.
Felzartamab plus lenalidomide-dexamethasone versus lenalidomide-dexamethasone for relapsed or refractory multiple myeloma: an open-label, parallel-controlled, randomised, phase 3 trial.
This phase 3 randomized trial evaluated the efficacy of felzartamab combined with lenalidomide-dexamethasone versus lenalidomide-dexamethasone alone in Chinese patients with relapsed or refractory multiple myeloma.
Rilzabrutinib, an oral Bruton tyrosine kinase inhibitor, in patients with warm autoimmune haemolytic anaemia: a prospective, single-arm, multicentre, phase 2b safety and clinical activity study (LUMINA 2).
The LUMINA 2 study evaluated the safety and clinical activity of rilzabrutinib, a Bruton tyrosine kinase inhibitor, in adults with warm autoimmune haemolytic anaemia.
Low-Dose Cytarabine Plus G-CSF Induction in Pediatric M2 Acute Myeloid Leukemia: A Multicenter Study.
This multicenter randomized controlled trial analyzed the efficacy and safety of low-dose chemotherapy (LDC) versus standard-dose chemotherapy (SDC) in 221 children with M2 acute myeloid leukemia.
Exposure-Response Analyses of Ropeginterferon Alfa-2b in Essential Thrombocythemia.
This meta-analysis examined the population pharmacokinetics and pharmacodynamics of ropeginterferon alfa-2b in patients with essential thrombocythemia (ET).
Long-term Follow-up of Third-generation Anti-CD30 CAR T-cell Therapy in Relapsed/Refractory CD30+ Lymphomas: A Single-Arm, Multicenter, Phase I/II Trial.
This single-arm, multicenter, phase I/II trial evaluated long-term outcomes of third-generation anti-CD30 CAR T-cell therapy in 44 patients with relapsed/refractory CD30+ lymphoma.
Ziftomenib with venetoclax and azacitidine for relapsed/refractory NPM1-mutated acute myeloid leukemia.
The KOMET-007 phase 1 trial evaluated the combination of ziftomenib with venetoclax and azacitidine in adults with relapsed/refractory NPM1-mutated acute myeloid leukemia (AML).
Management of Antineutrophil Cytoplasmic Antibody-Associated Alveolar Hemorrhage: A Bayesian Reanalysis of the PEXIVAS Trial.
This Bayesian reanalysis of the PEXIVAS trial focused on adults with antineutrophil cytoplasmic antibody-associated vasculitis and diffuse alveolar hemorrhage (DAH).
Lenalidomide-Related Diarrhea in Patients with Multiple Myeloma Is Associated with Gut Microbiota Dysbiosis and Disruption of the Bile Acid Pool.
This Phase II randomized controlled trial investigated the relationship between gut microbiota dysbiosis, bile acid pool disruption, and lenalidomide-related diarrhea (LRD) in patients with multiple myeloma.
Meningococcal meningitis in patients under prolonged eculizumab therapy: Clinical and immunological observations from a case series.
Two patients undergoing prolonged eculizumab therapy developed meningococcal meningitis despite prior vaccination. The clinical presentation included typical symptoms of meningitis, and diagnostic workups confirmed the…
Phase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein SL-172154 (SIRPα-Fc-CD40L) in patients with higher-risk myelodysplastic syndrome or acute myeloid leukemia.
This Phase I clinical trial evaluated the safety and efficacy of the bispecific CD47 inhibitor SL-172154 combined with azacitidine (AZA) in patients with higher-risk myelodysplastic syndrome (HR-MDS) or acute myeloid…
Tumor Profile, Clinical Features, and Outcomes in Individuals With Constitutional Trisomy 8: A Systematic Review of Case Reports and Case Series.
Constitutional trisomy 8 mosaicism (CT8M) is a rare chromosomal disorder with poorly characterized cancer risk. This systematic review aimed at summarizing reported cases of malignancy and associated clinical outcomes…
Spontaneous splenic rupture in a patient with congenital factor XIII deficiency: A case report and literature review.
A 32-year-old man with congenital factor XIII deficiency presented with sudden abdominal pain and hypovolemic shock. Contrast-enhanced abdominal CT showed a large perisplenic hematoma, and surgery confirmed splenic…
Retrospective RNA Sequencing Reclassifies a Historical t(5;12) Eosinophilic Neoplasm From Presumed PDGFRB Rearrangement to ETV6::ACSL6.
A woman with a chronic eosinophilic myeloid neoplasm had a t(5;12) that raised suspicion of PDGFRB involvement, but contemporary testing did not identify a rearrangement and empiric imatinib produced no meaningful…
The predictive value of early-pregnancy mean platelet volume for preeclampsia: A meta-analysis.
This meta-analysis assessed whether mean platelet volume (MPV) measured before 20 weeks’ gestation is associated with subsequent preeclampsia.
September 20269
A phase 1/1b study of the all-oral regimen CC-486 and venetoclax in acute myeloid leukemia.
This phase 1/1b study evaluated the all-oral regimen of CC-486 and venetoclax in patients with relapsed, refractory, and newly diagnosed acute myeloid leukemia (AML).
A phase 1b/2 study of ceralasertib, a selective inhibitor of ATR, in patients with relapsed or refractory MDS and CMML.
This phase 1b/2 study evaluated ceralasertib, an ATR inhibitor, in 44 adults with relapsed or refractory MDS and CMML. The overall response rate was 29.5%, with a median progression-free survival of 4.8 months and…
Clinical, economic, and quality-of-life outcomes of brexucabtagene autoleucel for the treatment of relapsed/refractory mantle cell lymphoma and B-cell acute lymphoblastic leukemia: A systematic literature review and meta-analysis.
This systematic literature review and meta-analysis evaluated the clinical, healthcare resource use, and quality-of-life outcomes of brexucabtagene autoleucel in adults with relapsed/refractory mantle cell lymphoma…
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder and skin changes) associated with Castleman disease and latent tuberculosis: a diagnostic challenge.
A woman in her 40s presented with progressive multisystem disease, including chronic distal neuropathy, constitutional decline, lymphadenopathy, and serosal effusions.
Masked polycythaemia vera presenting with extensive splanchnic venous thrombosis and mesenteric ischaemia.
A woman in her 60s with masked polycythaemia vera (PV) presented with extensive splanchnic venous thrombosis and mesenteric ischaemia after 5 years of management with phlebotomy and aspirin.
When two rare diseases meet: atypical hemolytic uremic syndrome and alkaptonuria in two siblings.
Two brothers from a consanguineous family presented with recurrent episodes of atypical hemolytic uremic syndrome (aHUS) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury.
FAT1-associated membranous nephropathy after hematopoietic stem cell transplantation: a case report and review of the literature.
A 55-year-old man developed nephrotic syndrome 52 months post-allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia.
BK Virus-Associated Hemorrhagic Cystitis in Nontransplanted Children With Hematological Malignancies: A Single-Center Case Series.
A single-center retrospective series identified six nontransplanted children with leukemia or lymphoma who developed BK virus-associated hemorrhagic cystitis during a 17-year period.
Flow Cytometry-Guided Diagnosis of Cortical T-Lymphoblastic Lymphoma Presenting With a Massive Mediastinal Mass and Borderline Bone Marrow Involvement.
A 57-year-old man presented with dyspnea, a large mediastinal mass causing superior vena cava syndrome, and pleural and pericardial effusions. Cytology and biopsy showed a diffuse blastoid lymphoid infiltrate.
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