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1357 articles

October 202624

Clinical ResearchRheumatologyOpen access

Effect of pre-visit computer-assisted history-taking with a structured copy-ready summary on documentation completeness in screening for inflammatory rheumatic diseases: a randomized pilot study.

This multicenter, parallel-group randomized pilot study assessed pre-visit computer-assisted history-taking (CAHT) with a structured, copy-ready summary in adults at increased risk of inflammatory rheumatic disease…

BMC Health Serv ResOct 9, 2026Read summary
Clinical ResearchPediatrics

Effect of Digital Technology-Based Interventions on Core Symptoms and Cognitive Function in Children With Attention-Deficit/Hyperactivity Disorder: Systematic Review and Meta-Analysis.

This systematic review and meta-analysis pooled 37 randomized controlled trials of digital interventions for children with ADHD, covering computer-based interventions, serious video games, exergames, and virtual…

J Med Internet ResOct 9, 2026Read summary
Clinical ResearchGeneral Surgery

Chronic postsurgical pain following thyroidectomy: A systematic review and meta-analysis.

This systematic review and random-effects meta-analysis assessed chronic postsurgical pain after thyroidectomy, synthesizing 16 studies involving 1538 patients.

Medicine (Baltimore)Oct 9, 2026Read summary
Clinical ResearchNephrology

Hypertension phenotypes in nondialysis patients with chronic kidney disease: systematic review and meta-analysis.

This systematic review and meta-analysis estimated the prevalence of hypertension phenotypes in people with nondialysis chronic kidney disease (CKD).

J HypertensOct 9, 2026Read summary
Clinical ResearchNeurology

Feasibility, Acceptability, and Appropriateness of an 8-Week Supervised Aerobic Exercise Intervention for Adults With Epilepsy: Pilot Randomized Controlled Trial.

This Phase IIb pilot randomized controlled trial assessed the feasibility, acceptability, and appropriateness of an 8-week supervised aerobic exercise program for adults with epilepsy aged 18-65 years.

JMIR Form ResOct 9, 2026Read summary
Clinical ResearchCardiology

Blinded withdrawal of randomized treatment with low-dose digoxin or placebo in heart failure: the DECISION trial.

This pre-specified analysis of the multicentre, randomised DECISION trial examined blinded withdrawal of long-term low-dose digoxin or placebo in patients with heart failure and reduced or mildly reduced ejection…

Eur Heart JOct 9, 2026Read summary
Clinical ResearchEndocrinology

Time-restricted feeding with resistance training is not superior to conventional feeding for body composition and muscle strength: a systematic review and meta-analysis.

This systematic review and meta-analysis examined time-restricted feeding (TRF) versus conventional diets in healthy adults aged 18 or older undertaking resistance training.

An Acad Bras CiencOct 9, 2026Read summary
Clinical ResearchCardiology

Sex differences in pharmacological treatment of heart failure: a meta-analysis of randomized trials.

This systematic review and meta-analysis examined sex differences in pharmacological treatment effects across randomized heart failure trials and whether women’s representation influenced estimated efficacy.

Eur Heart JOct 9, 2026Read summary
Clinical ResearchEndocrinology

Disease-Specific Optimal Blood Glucose Control Strategies in Critically Ill Patients: Retrospective Cohort Study and Network Meta-analysis.

This study combined a retrospective MIMIC-IV cohort analysis with a frequentist network meta-analysis of randomized trials to examine glucose-control targets in critically ill patients with sepsis, cardiac disease, or…

Nurs Crit CareOct 9, 2026Read summary
Clinical ResearchPsychiatry

Magnitude and Moderators of Depressive Symptom Improvement in Digital Placebo Arms: Systematic Review and Meta-Analysis.

This systematic review and meta-analysis examined blinded randomised controlled trials using digital placebos as comparators and reporting PHQ-9 outcomes.

J Med Internet ResOct 9, 2026Read summary
Clinical ResearchInfectious Diseases

Efficacy of Tecovirimat for the Treatment of Mpox Virus Infection in Humans: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

This systematic review and meta-analysis assessed tecovirimat efficacy and safety in patients with laboratory-confirmed mpox, comparing it with placebo or standard care in randomised controlled trials.

Rev Med VirolOct 9, 2026Read summary
Clinical ResearchPediatrics

Age-specific reference values for pulse wave velocity in paediatric populations: a systematic review with meta-analysis.

This systematic review and meta-analysis pooled observational studies reporting pulse wave velocity (PWV) in healthy children to establish age-specific reference values. Ten studies were included.

J HypertensOct 9, 2026Read summary
Clinical ResearchGastroenterology

Metallic versus plastic stents for the management of biliary obstruction: A GRADE-assessed systematic review and meta-analysis.

This GRADE-assessed systematic review and meta-analysis compared metallic with plastic stents for benign or malignant biliary obstruction, including randomized and observational studies.

Medicine (Baltimore)Oct 9, 2026Read summary
Clinical ResearchRadiology (Diagnostic)

Image-guided moderately hypofractionated proton beam therapy for localized prostate cancer: 5-year outcomes of a phase II trial.

This phase II clinical trial evaluated image-guided, moderately hypofractionated proton beam therapy (63 Gy RBE in 21 fractions) in 125 men with histologically confirmed localized prostate cancer (cT1c-3aN0M0).

J Radiat ResOct 9, 2026Read summary
Clinical ResearchPediatrics

Home-based, remotely supervised, high-intensity interval training and cardiorespiratory fitness in children and adolescents with post-infectious bronchiolitis obliterans: a randomised controlled trial.

This assessor-blinded, multicentre randomised controlled trial evaluated 16 weeks of home-based, real-time remotely supervised high-intensity interval training (HIIT) in children and adolescents aged 6–20 years with…

Eur Respir JOct 9, 2026Read summary
Clinical ResearchInfectious Diseases

Self-care practices of people living with HIV and hypertension or diabetes comorbidities in low-and-middle income countries: A systematic review.

This systematic review synthesised qualitative research on self-care among people living with HIV and hypertension or diabetes in low- and middle-income countries.

PLoS OneOct 9, 2026Read summary
Clinical ResearchUrology

Lung ultrasound-guided protocolized fluid management versus conventional central venous pressure-based management in monitoring extravascular lung water during the perioperative period of percutaneous nephrolithotomy: a randomized controlled trial.

This randomized controlled trial compared lung ultrasound (LUS)-guided protocolized fluid management with conventional central venous pressure (CVP)-based management in 181 patients undergoing elective percutaneous…

Ann MedOct 9, 2026Read summary
Clinical ResearchOrthopedic SurgeryOpen access

Efficacy and safety of intraoperative red blood cell salvage transfusion for spinal deformity surgery: a systematic review and meta-analysis.

This systematic review and meta-analysis pooled 22 observational studies of spinal deformity surgery, including 2,977 patients treated with intraoperative cell salvage (ICS) or without it.

Neurosurg RevOct 9, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Ketamine and esketamine during breastfeeding: a systematic review of human pharmacokinetic, infant and lactation outcomes.

This systematic review synthesised human evidence on ketamine and esketamine transfer into breast milk, infant exposure and outcomes, and breastfeeding outcomes after postpartum exposure.

Eur J Clin PharmacolOct 9, 2026Read summary
Clinical ResearchRadiology (Diagnostic)

Invasive interval breast cancer rates after digital breast tomosynthesis plus synthesised mammography versus digital mammography screening (TOSYMA): 24-month follow-up of the multicentre, open-label, randomised, controlled, superiority trial.

TOSYMA-2 was the 24-month follow-up of a multicentre, open-label, randomised superiority trial at 17 German screening sites.

Lancet OncolOct 9, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Effects of Sodium Bicarbonate Ringer's Solution versus Lactate Ringer's Solution on Emergence Time in Patients Undergoing Supratentorial Tumor Resection: A Randomized Controlled Trial.

This randomized controlled trial compared intraoperative sodium bicarbonate Ringer’s solution (BRS) with lactated Ringer’s solution (LRS) in patients undergoing elective supratentorial tumor resection.

Drug Des Devel TherOct 9, 2026Read summary
Clinical ResearchPulmonology

Effects of complementary therapies on physiological and psychological outcomes in chronic obstructive pulmonary disease patients: A systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis pooled 36 randomized controlled trials involving 3148 people with COPD to assess complementary therapies, including exercise-based and psychological approaches.

Respir MedOct 9, 2026Read summary
Clinical ResearchCardiology

Home versus centre exercise-based cardiac rehabilitation after coronary artery bypass grafting: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed exercise-based home cardiac rehabilitation (HBCR) versus centre-based rehabilitation (CBCR) or usual care after coronary artery bypass grafting.

Heart LungOct 9, 2026Read summary
Clinical ResearchOncology (Medical)

Attributable fraction of cardiac disease following radiotherapy among breast cancer survivors: a systematic review and meta-analysis.

This systematic review and random-effects meta-analysis assessed the relationship between mean heart dose (MHD) from radiotherapy and cardiac disease among breast cancer survivors.

J Radiat ResOct 9, 2026Read summary

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