Trending archive
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137 articles
June 20267
Remibrutinib impact on disease control, sleep, and quality of life: Analysis of phase 3 REMIX-1/2.
This phase 3 randomized controlled trial evaluated the effects of remibrutinib on disease control, sleep, and quality of life in adults with chronic spontaneous urticaria (CSU) who were symptomatic despite antihistamine…
Dupilumab Extended Interval Dosing in Chronic Rhinosinusitis With Nasal Polyps: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the effects of extending dupilumab dosing intervals beyond the standard every-two-weeks regimen in adults with chronic rhinosinusitis with nasal polyps.
Effect of depemokimab on asthma control and clinical outcomes: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of depemokimab on asthma control and clinical outcomes in patients with eosinophilic asthma.
Lonvoguran Ziclumeran - In Vivo CRISPR Gene Editing in Hereditary Angioedema.
This phase 3, multicenter, double-blind randomized trial evaluated a single intravenous infusion of lonvoguran ziclumeran, an investigational in vivo CRISPR gene-editing treatment, in patients aged 16 years or older…
Comparative Efficacy and Safety of Topical Bepotastine Besilate 1.5% Versus Sodium Cromoglycate 4% in Chronic Allergic Conjunctivitis: A Prospective Study.
This randomized controlled trial compared the efficacy and safety of bepotastine besilate 1.5% and sodium cromoglycate 4% in 100 adults with chronic allergic conjunctivitis.
Aerobic training versus behavioural intervention to increase physical activity on clinical control of people with moderate-to-severe asthma: A randomised clinical trial.
This randomized clinical trial compared aerobic training (AT) and behavioral intervention (BI) in improving clinical control among physically inactive adults with moderate to severe asthma.
Obexelimab for the Treatment of IgG4-Related Disease.
This phase 3 randomized controlled trial evaluated obexelimab in 194 patients with active IgG4-related disease. The study found that obexelimab significantly prolonged the time to the first disease flare requiring…
May 202615
Phase Ib/II Study of Preliminary Efficacy, Safety and Pharmacodynamics of MG-K10, a Humanised Monoclonal Antibody Targeting IL-4Rα, in Adult Chinese Patients With Asthma.
This Phase Ib/II randomized controlled trial evaluated the efficacy, safety, and pharmacodynamics of MG-K10, a monoclonal antibody targeting IL-4Rα, in Chinese adults with moderate-to-severe asthma.
Exploratory pilot trial of a multicomponent immunonutritional supplement in children with allergic asthma and rhinitis: The INAPRA study.
The INAPRA study was a multicenter, randomized, double-blind, placebo-controlled pilot trial investigating a multicomponent immunonutritional supplement in 40 children aged 5-12 with allergic asthma and rhinitis.
Ginger-based formulations for allergic rhinitis disease: a systematic review and meta-analysis of experimental studies in animals and humans.
This systematic review and meta-analysis evaluated the efficacy of ginger-based formulations for allergic rhinitis in both animal and human studies.
Improved asthma outcomes with dupilumab plus medium-dose inhaled corticosteroids vs placebo plus high-dose inhaled corticosteroids.
This phase III randomized controlled trial evaluated the effects of adding dupilumab to medium-dose inhaled corticosteroids (ICS) versus high-dose ICS alone in patients with uncontrolled moderate-to-severe asthma.
Depemokimab reduces asthma exacerbations similarly to other biologics.
This systematic review and network meta-analysis evaluated the efficacy and safety of depemokimab compared to other biologics in patients with severe type 2 asthma.
Eosinophilic vasculitis of aortic valve in EGPA: a life-threatening onset of disease.
A 51-year-old man with eosinophilic severe asthma and chronic rhinosinusitis presented with worsening dyspnea and cardiac arrest after two months of low-grade fever and malaise.
Glucagon-Like Peptide-1 Receptor Agonists in Asthma and Obesity-Associated Asthma: A Systematic Review of Clinical Outcomes and Translational Mechanisms.
This systematic review evaluated the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on asthma outcomes, particularly in individuals with obesity and type 2 diabetes.
Severe Pneumocystis jirovecii Pneumonia as the Sentinel Presentation of BENTA Disease: Case Report of a 3-Month-old Infant.
A 3-month-old infant with a history of acute respiratory distress syndrome and recurrent infections that did not respond to antibiotics had persistent interstitial lung opacities.
The swell within: a rare case of type 1 hereditary angioedema.
A 20-year-old woman presented with facial swelling and recurrent abdominal pain. Evaluation revealed type 1 hereditary angioedema due to low levels of C1 esterase inhibitor.
Safety, pharmacokinetics and pharmacodynamics of NXC736, a novel sphingosine-1-phosphate receptor modulator.
This randomized controlled trial evaluated the safety, pharmacokinetics, and pharmacodynamics of NXC736, a novel sphingosine-1-phosphate receptor modulator, in healthy male participants.
Predictors of Retention and Sustained Engagement With a 12-Month Asthma Self-Management App in Underserved Adults.
This randomized controlled trial examined predictors of dropout and sustained use of ASTHMAXcel PRO over 12 months among adults with asthma receiving daily controller medication at three Bronx primary care clinics.
Association between nocturnal asthma, symptom severity, and clinical outcomes: a systematic review.
This systematic review examined the relationship between nocturnal asthma and symptom severity, pulmonary function, and clinical outcomes in both adults and children.
Potential Pharmacogenomics (PGx), Human Leukocyte Antigen (HLA) Antiviral to Cephalosporin Crossover Reaction.
A 43-year-old man with type 2 diabetes and HLA-B*57:01 positivity received intravenous cefepime for pubic symphysis osteomyelitis associated with Pseudomonas.
Effect of nipocalimab on IgG responses to vaccinations and viral infections in patients with IgG autoantibody-mediated diseases: Post hoc analyses of three randomized, placebo-controlled trials.
This study evaluated the effects of nipocalimab on IgG responses to vaccinations and viral infections in patients with IgG autoantibody-mediated diseases, using post hoc analyses from three randomized…
HLA-B alleles confer susceptibility to sulfasalazine-induced severe cutaneous adverse reactions.
This meta-analysis investigated the genetic predisposition to sulfasalazine-induced severe cutaneous adverse reactions (SCARs) in Asian populations.
April 20262
Three years treatment with HDM allergen immunotherapy, omalizumab, or combination therapy in allergic asthma: clinical outcomes and biomarkers.
This randomized controlled trial evaluated the long-term effects of omalizumab, subcutaneous allergen immunotherapy (SCIT-HDM), and their combination in 79 patients with mild-to-moderate allergic asthma over 36 months.
Circulating Piwi-Interacting RNAs Associate With Childhood Asthma ICS Response With Vitamin D Effect Modification.
This randomized controlled trial investigated the association of circulating piwi-interacting RNAs (piRNAs) with inhaled corticosteroid (ICS) response in 492 children with asthma.
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