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2000 articles

August 202624

Clinical ResearchOncology (Medical)

The associations between household food insecurity and cancer: A comprehensive systematic review and meta-analysis of observational studies among adults.

This systematic review and meta-analysis examined observational evidence on household food insecurity (HFI) and cancer-related outcomes in adults.

Soc Sci MedAug 26, 2026Read summary
Clinical ResearchUrology

Extended Versus Non-Extended Lymphadenectomy in Radical Cystectomy for Bladder Cancer: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated the outcomes of extended versus non-extended lymphadenectomy during radical cystectomy for bladder cancer in 5671 patients across 15 studies.

J Surg OncolAug 26, 2026Read summary
Clinical ResearchOncology (Medical)

A phase I clinical study of the safety, tolerability, pharmacokinetics and pharmacodynamics of SHR-2106, an anti-CD40 antibody, following single intravenous or subcutaneous administration in healthy participants.

This Phase I randomized controlled trial evaluated the safety, pharmacokinetics, and pharmacodynamics of SHR-2106, an anti-CD40 antibody, in 51 healthy adults.

Eur J PharmacolAug 26, 2026Read summary
Clinical ResearchOncology (Medical)

Stereotactic body radiation therapy for hepatocellular carcinoma larger than 5 cm: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) ≥ 5 cm, including eleven studies and 424 patients.

Jpn J RadiolAug 26, 2026Read summary
Clinical ResearchOncology (Medical)

Lenvatinib plus pembrolizumab for the treatment of patients with non-BRAF mutated anaplastic thyroid cancer: A single center, phase 2 clinical trial.

This phase 2 clinical trial evaluated the efficacy of lenvatinib plus pembrolizumab in 25 patients with non-BRAF mutated anaplastic thyroid cancer (ATC).

Eur J CancerAug 26, 2026Read summary
Clinical ResearchOncology (Medical)

On-demand transarterial chemoembolisation combined with atezolizumab and bevacizumab in patients with untreated hepatocellular carcinoma (TALENTACE): a multicentre, randomised, open-label, phase 3 trial.

TALENTACE was a multicentre, open-label, randomised phase 3 trial comparing on-demand transarterial chemoembolisation (TACE) plus atezolizumab and bevacizumab with TACE alone in 342 patients with untreated, unresectable…

Lancet Gastroenterol HepatolAug 25, 2026Read summary
Clinical ResearchOncology (Medical)

Induction Paclitaxel-Cisplatin-Capecitabine for Nasopharyngeal Carcinoma.

This multicenter, randomized controlled trial evaluated the efficacy of induction chemotherapy with paclitaxel, cisplatin, and capecitabine (TPC) versus cisplatin and fluorouracil (PF) in patients with high-risk…

NEJM EvidAug 25, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Crizotinib versus observation or placebo for surgically resected early-stage ALK-positive non-small-cell lung cancer (Eastern Cooperative Oncology Group-American College of Radiology Imaging Network E4512): a phase 3 trial.

This multicentre, randomised phase 3 trial compared up to 2 years of adjuvant crizotinib with observation in patients with resected, early-stage ALK-positive non-small-cell lung cancer (NSCLC).

Lancet Respir MedAug 25, 2026Read summary
Clinical ResearchOncology (Medical)

Immune checkpoint inhibitor combinations across clinically distinct metastatic renal cell carcinoma populations with limited or heterogeneous trial evidence: A systematic review, evidence map, and meta-analysis.

This systematic review, evidence map, and meta-analysis assessed immune checkpoint inhibitor combinations in metastatic renal cell carcinoma populations underrepresented or variably represented in trials.

Crit Rev Oncol HematolAug 25, 2026Read summary
Case ReportHematology

Acute development of EBV+ T-cell lymphoproliferative disorder after treatment with rituximab for follicular lymphoma.

An elderly patient developed an EBV-positive T-cell lymphoproliferative disorder (LPD) following treatment with rituximab for follicular lymphoma.

J Infect ChemotherAug 25, 2026Read case
Clinical ResearchOncology (Medical)

Becotatug Vedotin Combined With Pucotenlimab in Platinum- and Immunotherapy-Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma.

This phase I/II clinical trial evaluated the combination of becotatug vedotin (BV) and pucotenlimab in patients with platinum- and immunotherapy-resistant recurrent or metastatic nasopharyngeal carcinoma (R/M NPC).

J Clin OncolAug 25, 2026Read summary
Case ReportOncology (Medical)

Primary ovarian non-small cell neuroendocrine carcinoma in an adolescent: The youngest case reported to date.

A 15-year-old girl presented with acute abdominal pain and a large cystic-solid abdominopelvic mass. Emergency fertility-sparing cytoreductive surgery confirmed the diagnosis of primary ovarian non-small cell…

Pathol Res PractAug 25, 2026Read case
Clinical ResearchOncology (Medical)Open access

B cell depletion improves therapeutic index of combination checkpoint blockade in patients with advanced melanoma.

This randomized controlled trial evaluated whether B-cell depletion with one cycle of rituximab could reduce immune-related adverse events (irAEs) from ipilimumab plus nivolumab in patients with advanced melanoma.

J Clin InvestAug 25, 2026Read summary
Clinical ResearchRadiology (Diagnostic)

Predicting TERT mutation in glioma patients using MRI-derived radiomics; A systematic review and meta-analysis.

This systematic review and meta-analysis assessed MRI-derived radiomics models for predicting TERT promoter mutation status in patients with glioma.

Eur J RadiolAug 25, 2026Read summary
Clinical ResearchOncology (Medical)

HPV circulating tumor DNA as a potential prognostic and predictive biomarker in head and neck squamous cell carcinoma: a systematic review.

This systematic review evaluated the prognostic and predictive value of human papillomavirus circulating tumor DNA (HPVctDNA) in head and neck squamous cell carcinoma (HNSCC), analyzing 60 studies with 8,234 patients.

Oral OncolAug 25, 2026Read summary
Case ReportPathology (Anatomic & Clinical)

Cytologic Features of Inflammatory Rhabdomyoblastic Tumor Using Conventional and Liquid-Based Cytology Preparations: A Case Report.

A man in his 60s with pharyngeal discomfort was diagnosed with tonsillar diffuse large B-cell lymphoma. Staging PET-CT also showed focal uptake in the left tibialis anterior muscle, initially raising concern for…

Diagn CytopatholAug 25, 2026Read case
Clinical ResearchHematology

Consolidation Therapy Based on Mutation Clearance in Acute Myeloid Leukemia.

This phase II multicenter trial evaluated the impact of leukemia-associated mutation (LAM) clearance on relapse-free survival (RFS) in 100 patients aged 18-60 with intermediate-risk acute myeloid leukemia (AML) in first…

NEJM EvidAug 25, 2026Read summary
Case ReportAllergy & Immunology

Successful 15-step desensitization protocol for nivolumab and ipilimumab after a skin-test confirmed anaphylaxis to polysorbate 80: case report.

A 53-year-old man with advanced melanoma developed grade III anaphylaxis during his first nivolumab infusion. Allergy testing showed immediate hypersensitivity to polysorbate 80 and a positive test to polysorbate 20…

Melanoma ResAug 24, 2026Read case
Clinical ResearchHematologyOpen access

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis.

The MAIA randomised controlled trial compared daratumumab plus lenalidomide and dexamethasone (D-Rd) with lenalidomide and dexamethasone (Rd) in transplant-ineligible adults with newly diagnosed multiple myeloma.

LeukemiaAug 24, 2026Read summary
Case ReportPhysical Medicine & Rehabilitation

Radiation Fibrosis Syndrome: A Case-Based Approach to Identification, Evaluation, and Treatment.

A patient developed Radiation Fibrosis Syndrome (RFS) following radiation therapy, presenting with multi-system involvement including neural and visceral structures.

Phys Med Rehabil Clin N AmAug 24, 2026Read case
Clinical ResearchOncology (Medical)

Sustained benefit of adjuvant olaparib in women with germline BRCA1- and BRCA2-associated high-risk HER2-negative early breast cancer: updated results from the OlympiA phase III trial.

This updated analysis of the randomised, multicentre phase III OlympiA trial assessed one year of adjuvant olaparib versus placebo in patients with germline BRCA1/2 pathogenic variants and high-risk, HER2-negative early…

Ann OncolAug 24, 2026Read summary
Case ReportRadiology (Diagnostic)

Visualization of Gerota Fascia Involved With Metastatic Melanoma on FDG PET/CT.

A 67-year-old man with melanoma underwent FDG PET/CT, which showed FDG-avid curvilinear soft tissue anterior, lateral, and posterior to the left kidney.

Clin Nucl MedAug 24, 2026Read case
Case ReportPathology (Anatomic & Clinical)

Sclerosing epithelioid fibrosarcoma with initial presentation as pulmonary masses: clinicopathological characteristics and diagnostic challenges.

This report analysed four cases of sclerosing epithelioid fibrosarcoma (SEF) presenting initially as solitary or multiple pulmonary masses.

PathologyAug 24, 2026Read case
Clinical ResearchOncology (Medical)

Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results of an international, multicentre, open-label, parallel-group, randomised, phase 2/3 trial.

The STAR-TREC trial evaluated long-course chemoradiotherapy (LCCRT) versus short-course radiotherapy (SCRT) for organ preservation in early-stage and intermediate-stage rectal cancer.

Lancet OncolAug 23, 2026Read summary

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