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845 articles
October 202624
Prenatal Microarray Incidentally Diagnoses a Novel Inherited NF1 Intragenic Duplication.
A woman with an undisclosed clinical diagnosis of NF1, lost to follow-up as a teenager, received a molecular diagnosis after prenatal chromosome microarray was performed because first-trimester screening indicated a…
Recurrent Angiomyofibroblastoma of the Vulva: MRI Characteristics and Long-Term Monitoring Insights.
A 33-year-old woman presented with a painless, pedunculated right vulvar mass, excised and diagnosed pathologically as angiomyofibroblastoma (AMFB).
Survival Outcomes in Metastatic Colorectal Cancer Patients with BRAF Mutations Undergoing Targeted Chemotherapy: A Reconstructed Individual Patient Data Meta-Analysis of Randomized Controlled Trials.
This reconstructed individual patient-data meta-analysis of 18 randomized controlled trials examined survival outcomes across targeted treatment classes in BRAF V600E-mutant metastatic colorectal cancer.
Diagnosis and Surgical Management of a Solitary Fibrofatty Lesion of the Finger Mimicking Pachydermodactyly.
A 30-year-old man had progressive, painless enlargement around the proximal interphalangeal joint of his right middle finger after long-term repetitive mechanical stimulation.
Asymptomatic Tattoo-Associated Cutaneous Nontuberculous Mycobacterial Infection: Case Report.
An immunocompetent 28-year-old man presented with monomorphic papules bearing collarettes of scale, diffusely distributed but confined to recently tattooed skin.
Atypical Fibroxanthoma Presenting as a Rapidly Enlarging Tender Papule: Case Report.
A 67-year-old woman with prior basal and squamous cell carcinomas presented with a rapidly enlarging, tender papule on the dorsal left hand that had not responded to topical 5-fluorouracil.
MLH1 AND MSH2 PROTEIN EXPRESSION LOSS AND MICROSATELLITE INSTABILITY IN COLORECTAL ADENOMAS OF PATIENTS WITH LYNCH SYNDROME: A SYSTEMATIC REVIEW AND META-ANALYSIS.
This systematic review and meta-analysis assessed the relationship between microsatellite instability (MSI) and loss of MLH1 or MSH2 expression in colorectal adenomas from people with Lynch syndrome.
Hypothalamic Neurochemical and Microglial Suppression in Long-Standing Human Hibernation-Like Syndrome.
A 57-year-old woman had a more than 30-year history of winter-associated hypothermia, neuroendocrine instability, psychomotor suppression and circannual rhythmicity.
Cutaneous clues: Malignant acanthosis nigricans and tripe palms as first signs of recurrent endometrial carcinoma.
A 73-year-old woman, disease-free for six years after treatment of stage IB endometrial endometrioid adenocarcinoma, developed acanthosis nigricans and tripe palms.
High-intensity focused ultrasound as a bridging vascular-modulating therapy for fertility-sparing management of placental site trophoblastic tumor complicated by uterine arteriovenous fistula: a case report.
A 23-year-old woman had persistently plateaued serum human chorionic gonadotropin after hysteroscopic management for suspected incomplete abortion.
Establishing Potosi Virus as a Human Pathogen: Fatal Neuroinvasive Disease in a B-Cell-Depleted Patient.
A 37-year-old woman with multiple sclerosis receiving long-term rituximab developed rapidly progressive dementia. MRI showed progressive generalized atrophy, while cerebrospinal fluid had only transient, minimal…
Effect of fasting and postprandial states on thyroid function test parameters and diagnostic interpretation: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed whether fasting versus postprandial sampling affects thyroid function tests and diagnostic classification.
Methyl aminolevulinate-PpIX mediated fluorescence-guided mapping of high-grade vulvar intraepithelial neoplasia: a pilot prospective clinical trial (PhotoDiVin).
This prospective, single-centre, single-arm pilot clinical trial assessed methyl aminolevulinate-mediated fluorescence mapping in 17 women with histologically confirmed high-grade vulvar intraepithelial neoplasia (dVIN…
Infantile posterior fossa atypical teratoid/rhabdoid tumor: navigating diagnostic complexity and molecular paradigms.
A female infant younger than 1 year presented with a massive cystic-solid posterior fossa tumor and rapidly developing obstructive hydrocephalus.
Recurrent Nodular Lymphocyte Predominant Hodgkin Lymphoma with Diagnostic Evolution Over Two Decades.
A 51-year-old man had a nearly 20-year history of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), with multiple relapses and prolonged remissions.
Familial Glioma in a Father and Son: Integrated Genomic and Multi-compartment Proteomic Profiling.
A 60-year-old father and his 35-year-old son presented with gliomas. The father’s tumor was glioblastoma, IDH-wildtype, WHO grade 4, with an unmethylated MGMT promoter; the son’s was astrocytoma, IDH-mutant, WHO grade…
Cranial and Spinal Epithelioid Hemangioma: Systematic Review and Illustrative Calvarial Case.
Cranial and neuraxial epithelioid hemangioma (EH) is exceptionally rare and anatomically heterogeneous. We systematically reviewed reported cerebral, cranial osseous, primary non-osseous spinal epidural, and…
Peritoneal Tuberculosis and Chronic Myeloid Leukaemia: A Case of Hickam's Dictum.
A 34-year-old man presented with persistent fever, ascites, thrombocytosis and clinical deterioration despite broad-spectrum therapy.
Vulvar High-Grade Squamous Intraepithelial Lesion in Primary Lymphedema With Severe Genital Lymphorrhea: A Case Report.
A 37-year-old woman with childhood-onset primary lymphedema developed recurrent right leg and genital swelling after 31 years of clinical quiescence, with vulvar erythema, follicular lesions, and persistent lymphorrhea.
POSTERIOR DISLOCATION OF POSTERIOR LAMELLAR CORNEAL GRAFT WITH VIABLE ENDOTHELIAL CELLS.
A middle-aged man with prior traumatic eye injury and pars plana vitrectomy, lensectomy, and scleral-sutured intraocular lens fixation developed corneal edema requiring Descemet stripping automated endothelial…
VITREOUS METASTASIS OF LARYNGEAL CARCINOMA PRESENTING AS A WHITE MASS: A CASE REPORT.
A 56-year-old man receiving immunochemotherapy for laryngeal carcinoma presented with two weeks of left-eye photopsia. Examination showed mild anterior chamber and vitreous cells, slight macular edema, and a white…
SUBRETINAL LAVAGE DURING DIAGNOSTIC VITRECTOMY: AN ADJUNCTIVE TECHNIQUE FOR CELL SAMPLING IN SUSPECTED VITREORETINAL LYMPHOMA.
In patients with suspected vitreoretinal lymphoma and predominant subretinal involvement, standard vitreous sampling may have limited sensitivity.
Pearls & Oy-sters: Beyond the Bone Marrow-VEXAS Syndrome Presenting as Subacute Encephalomyelitis.
A 70-year-old man with myelodysplastic syndrome and confirmed VEXAS syndrome (UBA1 p.Met41Thr) developed subacute ascending paresthesia, Lhermitte sign, and urinary hesitancy.
B cell subsets are associated with durable responses in distinct cancer types after immune checkpoint inhibition.
This study examined B-cell responses and outcomes after immune checkpoint inhibition, combining a prospective randomized phase 2 trial of 106 patients with single-cell profiling of intratumoral B cells from 152 patients…
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