Trending archive
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137 articles
July 202611
Efficacy and safety of press-needle therapy for allergic rhinitis in children: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of press-needle therapy for allergic rhinitis in children, analyzing 24 randomized controlled trials with 1625 participants.
Marked IgE elevation and eosinophilia in a COPD patient ultimately diagnosed with mycobacterium intracellulare pulmonary disease.
A 65-year-old man with COPD presented with persistent eosinophilia and significantly elevated total IgE levels. Initial evaluations for allergic diseases were negative.
The Dermatologic Burden of Flooding: A Systematic Review of Epidemiology, Clinical Manifestations, and Management in a Warming World.
This systematic review synthesized 12 epidemiological studies, including retrospective cohorts, time-series, and case-crossover designs, covering more than 71 million patient encounters across nine countries.
Defining Minimal Clinical Disease Activity and Remission in Severe Asthma: A Modified Delphi Consensus.
This systematic literature review and modified Delphi consensus sought to standardize definitions of minimal clinical disease activity and remission in severe asthma.
Stapokibart reduces blood eosinophil counts in patients with moderate-to-severe atopic dermatitis: a post-hoc analysis from phase II and phase III clinical trials.
This post-hoc analysis from phase II and III trials evaluated the impact of stapokibart on blood eosinophil counts in patients with moderate-to-severe atopic dermatitis.
Early response to ivarmacitinib and its impact on long-term efficacy in patients with moderate-to-severe atopic dermatitis: a post hoc analysis of a phase-III trial.
This post hoc analysis of a phase III randomized controlled trial evaluated the early response to ivarmacitinib in 225 patients with moderate-to-severe atopic dermatitis.
Long-term efficacy and safety of dupilumab in patients enrolled from Latin American centers from the open-label extension LIBERTY ASTHMA TRAVERSE study.
This post hoc analysis of the open-label extension TRAVERSE study examined long-term dupilumab outcomes in patients with moderate-to-severe asthma enrolled at Latin American centers after completing a phase 2b or phase…
Bivariate analysis of symptom and medication score effect sizes in grass pollen allergen immunotherapy reveals route-dependent dissociation: implications for the combined symptom and medication score.
This meta-analysis examined the relationship between symptom scores (SS) and medication scores (MS) in 14 randomized controlled trials of grass pollen allergen immunotherapy (AIT) involving 4850 patients.
Postmortem tryptase as a diagnostic marker in fatal anaphylaxis: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated postmortem serum tryptase as a diagnostic marker in fatal anaphylaxis, analyzing data from seven studies involving 105 anaphylactic deaths and 449 controls.
Allergic Fungal Rhinosinusitis: Distinct Clinical Features, Diagnostic Challenges, and Evolving Therapeutic Strategies.
The article describes a representative case of unilateral allergic fungal rhinosinusitis (AFRS) in a young, immunocompetent patient.
Benzalkonium Chloride in Eye Drops Causing Allergic Contact Dermatitis: A Case Series.
The report describes three patients who developed allergic contact dermatitis (ACD) associated with benzalkonium chloride (BAK) in ophthalmic drops. BAK is a commonly used preservative in eye-drop formulations.
June 202613
A novel JAK1 mutation identified in a patient with severe atopic dermatitis phenotype: Mechanistic insights and IL-4Rα targeted therapy.
A child with early-onset severe atopic dermatitis presented with eosinophilia, elevated IgE, and growth retardation. Genetic analysis identified a novel JAK1 gain-of-function mutation (p.L783F).
Usability and Acceptance of Autoinjector and Prefilled Syringe Devices by Patients with Generalized Myasthenia Gravis in a Human Factors Study.
This randomized controlled trial evaluated the usability and acceptance of a prefilled syringe with needle safety device (PFS-SD) and an autoinjector (AI) among patients with generalized myasthenia gravis (gMG).
Dupilumab outcomes in pediatric asthma by early eosinophil status: Post hoc analysis of VOYAGE/EXCURSION.
This post hoc analysis of the randomized controlled trials VOYAGE and EXCURSION evaluated the long-term efficacy and safety of dupilumab in children aged 6 to 11 with type 2 asthma, focusing on those with early…
Alpha-Gal Syndrome-A Case Series of Successful Transcatheter Mammalian-Derived Aortic Valve Replacements.
Three patients with documented Alpha-gal syndrome (AGS) successfully underwent transcatheter aortic valve replacement (TAVR) using bovine or porcine-derived bioprosthetic valves.
Pharmacokinetics and pharmacodynamics of AQST-109 sublingual film in oral allergy syndrome: A phase 2 study.
This phase 2, open-label, randomized, fixed-sequence crossover study compared the pharmacokinetics and pharmacodynamics of sublingual AQST-109 in adults with screening-confirmed oral allergy syndrome, with and without…
A Novel Device to Improve the Tolerability of Intranasal Corticosteroid Sprays for Allergic Rhinitis and Postoperative Chronic Rhinosinusitis: A Crossover Trial.
This randomized controlled trial evaluated a novel nasal adaptor for metered-dose inhalers (MDIs) in patients with allergic rhinitis (AR) and postoperative chronic rhinosinusitis (CRS).
Effects of positive psychotherapy on anxiety and quality of life in chronic Urticaria.
This randomized controlled trial examined the effects of positive psychotherapy on anxiety and quality of life in 66 patients with Chronic Spontaneous Urticaria (CSU).
Diverse Trial Designs, Populations, and Outcomes: A Systematic Literature Review of Trials for the Treatment of Hereditary Angioedema Attacks.
This systematic literature review evaluated 12 phase 2-3 randomized clinical trials for on-demand treatments of hereditary angioedema (HAE) attacks.
Dupilumab Efficacy in Children With Uncontrolled, Moderate-to-Severe, Type 2 Asthma by Allergen Sensitization Level.
This post hoc analysis of the multicenter, randomized VOYAGE trial examined dupilumab by allergen sensitization status in children aged 6 to 11 years with uncontrolled, moderate-to-severe type 2 asthma.
Pediatric Neuroinflammatory and Neuropsychiatric Syndromes Associated with Dupilumab Treatment for Atopic Dermatitis.
Four children treated with dupilumab for atopic dermatitis developed neuroinflammatory syndromes characterized by behavioral changes, language impairment, and neurodiagnostic abnormalities within 2-6 months of starting…
Inhaled Salbutamol Versus Placebo for the Treatment of Acute IgE-Mediated Abdominal Pain From Allergic Food Reactions (INSPIRE Trial): A Double-Blind Randomized Trial.
The INSPIRE trial evaluated inhaled salbutamol's efficacy in treating moderate-to-severe IgE-mediated abdominal pain in patients aged 6 to 55 years.
The Effect of an Augmented Reality Game on Pain and Fear Levels and Care Satisfaction During Allergy Testing in Children Aged 4-12: A Randomized Controlled Study.
This randomized controlled trial evaluated the impact of an augmented reality game on pain, fear, and care satisfaction in 66 children aged 4-12 undergoing allergy skin prick tests.
Safety and Early Immune Dynamics Following First Dose of the MMR Vaccine in a Toddler Treated With a JAK Inhibitor.
A toddler receiving baricitinib was accidentally given the live measles-mumps-rubella (MMR) vaccine. No vaccine-related adverse events were reported.
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