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2000 articles
September 202624
Clinical features and management of GPRC5D-associated adverse events in novel GPRC5D × CD3 bispecific talquetamab-treated relapsed/refractory multiple myeloma patients: the MonumenTAL-1 China cohort experience.
This phase I clinical trial evaluated the safety profile of talquetamab, a GPRC5D×CD3 bispecific antibody, in 41 Chinese patients with relapsed/refractory multiple myeloma.
Patient-specific 3D-printed Anatomical Models for Intraoperative Osteotomy Verification in Joint-sparing Surgery for Osteosarcoma: A Report of Two Cases.
Two patients with osteosarcoma around the knee underwent joint-sparing limb-salvage surgery using patient-specific 3D-printed anatomical models for intraoperative verification of osteotomy levels.
Clinical and Biochemical Recovery From Immune Checkpoint Inhibitor-Induced Diabetes With Seroconversion of GAD Antibodies.
A patient with melanoma developed abrupt-onset symptomatic hyperglycemia and mild ketosis after treatment with ipilimumab and nivolumab, indicating immune checkpoint inhibitor-induced diabetes (ICI-D).
Could Subjective Cognitive Complaints Give the Facts of Objective Cognitive Impairments in Non-Central Nervous System Cancer? A Systematic Review.
This systematic review examined the relationship between subjective cognitive complaints (SCCs) and objective neuropsychological assessments in non-central nervous system cancer patients.
Immune Checkpoint Inhibitor-Induced Pancreatitis.
A case report described five female patients who developed immune checkpoint inhibitor-induced pancreatitis (ICIPI) after receiving combination ICI therapy.
Tandem Double Inversion Resolves the Structural Paradox Underlying Recurrent KAT6A::NCOA2 Fusion in Acute Myeloid Leukemia.
A case of acute myeloid leukemia (AML) presented with the rare KAT6A::NCOA2 fusion, typically associated with inv(8)(p11q13). Genomic profiling revealed an unexpected MTFR1::KAT6A rearrangement.
Immune Checkpoint Inhibitors in Relapsed/Refractory Anaplastic Large Cell Lymphoma (ALCL): A Case Report and Review of the Literature.
A patient with relapsed/refractory anaplastic large cell lymphoma (ALCL) achieved sustained complete remission following treatment with a PD-1 inhibitor after multiple prior therapies.
First-Line PD-1 Inhibitor-Based Therapy for Advanced or Metastatic Esophageal Squamous Cell Carcinoma: A Revised Systematic Review and Meta-Analysis of Phase III Trials.
This systematic review and meta-analysis evaluated phase III trials comparing first-line PD-1 inhibitor-based therapy to chemotherapy in advanced esophageal squamous cell carcinoma (ESCC).
Impact of beta-blockers on prognostic outcomes in solid cancers: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of beta-blocker use on survival outcomes in patients with solid cancers, analyzing data from 603,827 patients across 84 studies.
Li-Fraumeni syndrome presenting with temporomandibular chondroblastic osteosarcoma following recurrent glioma.
A man in his 20s with a history of recurrent glioma presented with rapid-onset trismus and swelling in the left temporomandibular region.
Performance of Machine Learning Models Based on Medical Imaging in Predicting Pathological Grade of Clear Cell Renal Cell Carcinoma.
This meta-analysis evaluated the diagnostic accuracy of machine learning models based on medical imaging for predicting the pathological grade of clear cell renal cell carcinoma (ccRCC) in 12,675 patients.
A Novel BRCA1 Pathogenic Variant in Tunisian Patient With High Grade Ovarian Cancer: Favorable Therapeutic Response to Olaparib.
A 50-year-old woman presented with severe anemia due to heavy menometrorrhagia. Initial evaluations were unremarkable, but exploratory laparotomy revealed a peritoneal nodule.
Association of Ferritin Levels With Cytokine Release Syndrome in CAR T-Cell Therapy: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the role of ferritin levels in predicting cytokine release syndrome (CRS) in CAR T-cell therapy recipients.
Population pharmacokinetics for the CTLA-4 modulator gotistobart in patients with advanced solid tumors.
This phase I clinical trial investigated the population pharmacokinetics of gotistobart, a monoclonal antibody targeting CTLA-4, in 632 patients with advanced solid tumors.
Comparative Efficacy of BTK Inhibitors in Treatment-Naïve and Relapsed/Refractory Mantle Cell Lymphoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy of Bruton tyrosine kinase inhibitors (BTKis) in treatment-naïve and relapsed/refractory mantle cell lymphoma (MCL).
A Multicentre Phase II Study of Trifluridine/Tipiracil in Recurrent/Metastatic Platinum-Resistant Nasopharyngeal Carcinomas.
This multicenter Phase II study evaluated the efficacy and safety of trifluridine/tipiracil (FTD/TPI) in 35 patients with recurrent/metastatic platinum-resistant nasopharyngeal carcinoma.
Effect of a Nurse-Navigated Game-Based Program on Transition Readiness and Psychosocial Outcomes in Adolescents With Osteosarcoma: A Cluster-Nonrandomized Controlled Study.
This cluster-nonrandomized controlled study evaluated the impact of a nurse-navigated game-based intervention (N2-GBI) on transition readiness in 59 adolescents with osteosarcoma.
Effect of Post-Discharge Oral Nutritional Supplements on Nutritional Status in Patients after Gastrectomy: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the impact of post-discharge oral nutritional supplements (ONS) on nutritional status in 1,736 patients after gastrectomy for gastric cancer.
XY0206 targets FLT3-dependent resistance states in acute myeloid leukemia.
This phase I/II clinical trial evaluated XY0206 monotherapy in patients with relapsed or refractory acute myeloid leukemia (AML), alongside laboratory and animal studies of its FLT3-directed activity.
The Clinical Application of Refined Risk Estimates Study in BRCA1 and BRCA2 Pathogenic Variant Carriers: A Randomized Controlled Trial.
This randomized controlled trial evaluated the impact of genotype-informed personalized cancer risk estimates (GRE) versus standard lifetime cancer risk estimates (SRE) on decisional conflict in women with BRCA1/BRCA2…
Effects of transcutaneous electrical acupoint stimulation versus acupressure on the trajectories of multidimensional adverse reactions to chemotherapy in breast cancer patients: a secondary analysis of a randomized controlled trial.
This secondary analysis of a randomized controlled trial examined the effects of transcutaneous electrical acupoint stimulation (TEAS) and self-acupressure (SA) on multidimensional adverse reactions in 189 breast cancer…
Paraneoplastic Myopathy as a Possible Initial Presentation of Sporadic Burkitt Lymphoma in an Immunocompetent Adult: A Case Report.
An immunocompetent adult male presented with acute progressive proximal muscle weakness and elevated creatine phosphokinase levels. Extensive evaluations ruled out autoimmune and metabolic causes.
Topical crushed morphine tablets for dressing-related pain in a malignant fungating wound in a resource-limited palliative care setting.
A woman in her 70s with metastatic breast cancer presented with a painful malignant fungating wound in a palliative care unit in India. Despite systemic oral morphine, she experienced significant dressing-related pain.
Intrathecal Chemotherapy Through Ommaya Reservoir in Leptomeningeal Metastasis From Cervical Cancer: A Rare Case Report and Literature Review.
A 61-year-old woman with stage IVB cervical squamous cell carcinoma presented with acute headache and diplopia during systemic chemotherapy. Brain MRI indicated leptomeningeal metastasis, confirmed by CSF cytology.
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