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1382 articles
July 20264
Integrated genomic and biochemical diagnosis of a novel homozygous start-loss variant in AKR1D1 associated with neonatal cholestasis.
A 3-month-old male presented with severe neonatal cholestasis and elevated tyrosine levels detected in newborn screening. Despite transient normalization of tyrosine, recurrent hyper-tyrosinemia and progressive…
Blood-Based Biomarkers Predict Cerebral Palsy and Cognitive Delay in Hypoxic-Ischemic Encephalopathy: A Secondary Analysis of the High-Dose Erythropoietin for Asphyxia and Encephalopathy Randomized Controlled Trial.
This secondary analysis of a randomized controlled trial evaluated blood-based biomarkers in 180 infants with moderate-severe hypoxic-ischemic encephalopathy (HIE) to predict cerebral palsy (CP) and cognitive/language…
Crigler-Najjar Syndrome (Type 1) - A Case Report and Review of Literature.
A 7-year-old girl with Crigler–Najjar syndrome type I and kernicterus presented with fever and breakthrough seizures during an upper respiratory infection.
Sonographic Appearances of Synchronous Bilateral Testicular Tumors with Different Pathological Types: A Case Report.
A child was found to have synchronous tumors in both testes. Preoperative ultrasound demonstrated lesions that were subsequently identified as a yolk sac tumor in the left testis and a teratoma in the right.
June 202620
Immediate Effects of Exercise and Manual Therapy on Cervico-Mandibular Mobility and Postural Alignment in Children with Spastic Cerebral Palsy: A Randomized Crossover Trial.
This randomized crossover trial investigated the immediate effects of exercise and manual therapy on cervico-mandibular mobility in 52 children with spastic cerebral palsy (mean age 10.8 years).
Dupilumab outcomes in pediatric asthma by early eosinophil status: Post hoc analysis of VOYAGE/EXCURSION.
This post hoc analysis of the randomized controlled trials VOYAGE and EXCURSION evaluated the long-term efficacy and safety of dupilumab in children aged 6 to 11 with type 2 asthma, focusing on those with early…
Cerebral, spinal, ophthalmological and skeletal findings associated with abusive and non-abusive head injury in children under 2 years old: A systematic review.
This systematic review examined differences in clinical findings between children under 2 years with abusive head trauma (AHT) and non-abusive head trauma (nAHT).
Effect of malaria parasitaemia on antibody responses to single-dose and two-dose HPV vaccination: results from the DoRIS dose-reduction immunogenicity trial in Tanzanian girls.
This randomized controlled trial evaluated the impact of malaria parasitaemia on HPV vaccine immune responses in 930 HIV-negative Tanzanian schoolgirls aged 9-14 years.
Chronic hyponatraemia with a reset osmostat: when abnormal is normal.
An adolescent was evaluated for chronic hyponatraemia. Assessment of volume status indicated a euvolaemic presentation, prompting consideration of causes beyond salt depletion or excess water.
Biallelic Variant in HAPLN1 is Associated With Skeletal Dysplasia With or Without Congenital Heart Disease.
Four individuals from an extended consanguineous Kuwaiti family had a skeletal dysplasia characterized by shortened long bones in the upper and lower limbs and short, stubby metacarpals.
Prenatal and Postnatal Ultrasound Findings of Congenital Diaphragmatic Hernia Associated With Myelomeningocele, Chiari II Malformation, and Renal Dysplasia.
A female neonate born at 35 weeks had severe left-sided Bochdalek congenital diaphragmatic hernia, lumbosacral myelomeningocele, Chiari II malformation, and unilateral renal dysplasia.
Impact of Phototherapy Blanket Treatment on Need for Overhead Phototherapy in Term Infants-A Randomised Controlled Trial (The Babies in Blankets Trial-BiB Trial).
This single-centre randomised controlled trial assessed whether phototherapy blankets could prevent overhead phototherapy in clinically well infants born at ≥35 weeks, older than 24 hours, whose bilirubin levels were…
Perioperative analgesic efficacy of ultrasound-guided erector spinae plane block and posterior transversus abdominis plane block in paediatric patients undergoing open pyeloplasty: A prospective randomised trial.
This prospective randomized trial evaluated the analgesic efficacy of ultrasound-guided Erector spinae plane block (ESP) versus posterior transversus abdominis plane block (pTAP) in 40 pediatric patients undergoing open…
Efficacy, Safety, Quality of Life, and Adherence of Dupilumab in Pediatric Atopic Dermatitis: A Systematic Review.
This PRISMA-guided systematic review assessed dupilumab efficacy, safety, quality of life, and adherence in children aged 0–12 years with moderate-to-severe atopic dermatitis.
Dural Manifestation of Langerhans Cell Histiocytosis: Multimodality Imaging Approach.
A 2-year-old boy presented with scalp swelling, leading to the diagnosis of Langerhans cell histiocytosis (LCH) with dural involvement.
18 F-MFBG Uptake From Multiple Focal "Hot Spots" to Superscan in a Pediatric Patient With High-risk Neuroblastoma.
A 5-year-old girl with high-risk neuroblastoma presented for 18 F-MFBG PET/CT, which revealed multiple discrete focal 'hot spots.' Bone marrow aspiration confirmed metastatic involvement.
The Role of STAG2, CDKN2A, and TP53 Genes in Ewing Sarcoma: A Report of a Rare Case of Primary Ewing Sarcoma of the Kidney With Favorable Outcome.
A pediatric patient presented with stage IV primary Ewing sarcoma of the kidney, a rare and aggressive malignancy. The patient underwent upfront surgical resection followed by radiation therapy, resulting in a durable…
Radiation-induced Continuous False-positive 18F-MFBG Uptake in the Perirenal Space of a Pediatric Neuroblastoma Patient.
An 18F-MFBG PET/CT scan was conducted to evaluate the therapeutic response following treatment with chemotherapy, surgery, and radiotherapy.
Brain Death Determination During VA-ECMO After Pediatric Cardiac Surgery: A Case-Based Analysis of the 2023 Unified Consensus.
A pediatric patient on venoarterial ECMO after cardiac arrest underwent brain death/death by neurologic criteria (BD/DNC) assessment.
Effect of an enhanced recovery after surgery protocol for children with acute appendicitis: A randomized controlled trial.
This randomized controlled trial evaluated the modified Enhanced Recovery After Surgery (mERAS) protocol in 82 children aged 6-17 undergoing appendectomy.
Phase 3 Trial of Oral Infigratinib in Children with Achondroplasia.
This phase 3, multicenter, double-blind, placebo-controlled trial evaluated the efficacy of oral infigratinib in children aged 3 to 17 with achondroplasia.
Virtual Reality Education for Hospitalized Pediatric Patients Improves Intrinsic Motivation: A Prospective, Randomized Crossover Study.
This pragmatic, randomized crossover trial assessed the impact of bedside virtual reality (VR) education on intrinsic motivation in hospitalized pediatric patients aged 5 to 25 years.
Intra-Abdominal Umbilical Vein Varix With Postnatal Portal Vein Thrombosis: A Case Report.
A fetus of a 23-year-old primiparous woman was found to have an intra-abdominal umbilical vein varix at 24 + 2 weeks of gestation, with turbulent flow.
Evaluating the role and effectiveness of protocol liver biopsies in pediatric post-transplant care: a systematic review.
This systematic review assessed the effectiveness of protocol liver biopsies in detecting subclinical histopathological abnormalities in 2004 pediatric liver transplant recipients.
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