Trending archive
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937 articles
March 202621
Antibiotic Use During Gastrointestinal Infections Increases the Risk of Developing Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined new irritable bowel syndrome (IBS) diagnoses among people with documented antibiotic exposure compared with unexposed controls.
Sirolimus for the treatment of steroid-refractory hepatotoxicity following AAV gene therapy in patients with Duchenne muscular dystrophy.
Four boys aged 5–16 years with Duchenne muscular dystrophy developed acute liver inflammation after delandistrogene moxeparvovec-rokl gene therapy. All were already receiving chronic corticosteroids.
Beyond rejection risk: Identifying ideal candidates for pretransplant immune checkpoint inhibitors for HCC.
This systematic review assessed immune checkpoint inhibitors (ICIs) used as bridging or downstaging therapy before liver transplantation for hepatocellular carcinoma.
Combined Hepatocellular-cholangiocarcinoma Patient Treated with Durvalumab Plus Gemcitabine and Cisplatin.
A 55-year-old man with lower abdominal pain and diarrhea was referred to our hospital. Computed tomography (CT) revealed a hypovascular liver tumor, lymph node/bone metastases, and peritoneal dissemination.
Enhancer of Zeste Homolog 1 and 2 Inhibitor-induced Colitis Mimicking Immune Checkpoint Inhibitor-induced Colitis.
An 80-year-old woman with relapsed nodal T-follicular helper cell lymphoma developed severe watery diarrhea while receiving valemetostat, an EZH1/2 inhibitor. Colonoscopy showed diffuse mucosal erythema and edema.
Algorithm-Based Care for Treating Chronic Pancreatitis: A Nationwide Stepped-Wedge Cluster Randomized Controlled Trial.
This nationwide stepped-wedge cluster-randomized controlled trial compared evidence-based algorithm-guided care with current practice in 418 patients with chronic pancreatitis across 26 Dutch centers.
Gut Microbiome Composition and Function, Diet, and Clinical Factors in Relation to Fermentable Carbohydrate-Induced Bloating: A Double-Blind, Randomized, Crossover Trial.
This double-blind, placebo-controlled, randomized crossover trial examined clinical, dietary, microbial, and fermentation factors associated with bloating after fermentable carbohydrates in people with functional…
Relative Effects of Time-Restricted Eating, Energy-Restricted Eating, and Unrestricted Eating on Eating Patterns and Dietary Intake: Results From a Randomized Controlled Trial.
This secondary analysis of a randomized controlled trial examined eating patterns and dietary intake among adults with obesity assigned to time-restricted eating (TRE), energy-restricted eating (ER), or unrestricted…
ASSOCIATION BETWEEN GASTROESOPHAGEAL REFLUX DISEASE AND PEPTIC ULCER IN ADULTS AND THE DEVELOPMENT OF PERIODONTAL CHANGES AND DENTAL CARIES: SYSTEMATIC REVIEW AND META-ANALYSIS.
This systematic review and meta-analysis examined associations between gastroesophageal reflux disease (GERD) or peptic ulcer and dental caries or periodontal disease.
Clinical Efficacy Evaluation of a Continuous Glucose Monitoring-Guided Forecasting Algorithm to Mitigate Postbariatric Hypoglycemia: A Randomized Controlled Trial.
This randomized controlled trial evaluated whether a continuous glucose monitoring (CGM)-guided forecasting algorithm could reduce postbariatric hypoglycemia during a standardized meal test in 59 people after Roux-en-Y…
Longitudinal assessment of the circulating cytokine profile of severe alcohol-associated hepatitis.
This longitudinal biomarker analysis used samples from 89 patients with severe alcohol-associated hepatitis (MELD≥20) enrolled in a multicenter, double-blind randomized trial comparing anakinra-based treatment with…
Changes in quality of life in colorectal cancer screening: A multicentre trial in populations in China.
This multicentre randomised trial assessed quality of life among 19,373 participants in China allocated to one-time colonoscopy, annual faecal immunochemical testing (FIT) with colonoscopy after a positive result, or…
Liver Injury Associated With Kratom ( Mitragyna speciosa ): A Systematic Review.
This PRISMA 2020 systematic review examined published evidence on kratom (Mitragyna speciosa) use and liver toxicity. It included 31 studies describing 32 cases of kratom-associated liver injury, most from…
Mirikizumab Long-Term Efficacy and Safety in Patients With Crohn's Disease: Results From the VIVID-2 Open-Label Extension Trial.
This interim analysis of the VIVID-2 open-label extension followed patients with moderately to severely active Crohn’s disease who had received mirikizumab in the VIVID-1 randomized trial and continued treatment for up…
Not all small bowel pneumatosis is ischaemia: a case-based systematic review of non-ischaemic causes.
A 74-year-old man developed small-bowel pneumatosis after ileostomy reversal. Computed tomography initially raised concern for bowel ischaemia, but he had no clinical or biochemical evidence of sepsis.
Efficacy of NAs in combination with Peg-IFN for functional cure in patients with CHB: a meta-analysis of RCTs.
This meta-analysis of 16 randomised controlled trials assessed nucleoside (acid) analogues (NAs) combined with pegylated interferon (Peg-IFN) for functional cure in people with chronic hepatitis B.
Upfront endoscopic necrosectomy versus step-up endoscopic approach for walled-off pancreatic necrosis: a systematic review and meta-analysis.
This systematic review and meta-analysis compared upfront endoscopic necrosectomy (UEN) with a step-up endoscopic approach (SUEN) for walled-off pancreatic necrosis.
Efficacy and safety of endoscopic ultrasound-guided choledochoduodenostomy compared with endoscopic ultrasound-guided gallbladder drainage for palliation of malignant distal biliary obstruction: a systematic review and meta-analysis.
This systematic review and meta-analysis compared endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) with gallbladder drainage (EUS-GBD) for palliation of malignant distal biliary obstruction when ERCP is not…
A Transfusion-transmitted Chronic Hepatitis E Virus Infection after Allogeneic Bone Marrow Transplantation with Viral Clearance Following Immunosuppression Tapering.
A 62-year-old woman with myelofibrosis developed liver dysfunction after allogeneic bone marrow transplantation. Testing showed anti-HEV IgA and HEV RNA, and matching viral RNA sequences in the transfusion donor and…
Successful Immunosuppressive Therapy for Aseptic Abscess Syndrome Presenting with a Fever of Unknown Origin.
A 70-year-old woman presented with recurrent fever, multiple colonic aphthae, and painful nodules on her limbs. CT showed multiple splenic lesions, and aspiration yielded white purulent fluid, initially suggesting…
Global Prevalence of Adherence to Gluten-Free Diet in Patients With Celiac Disease: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis estimated adherence to a gluten-free diet (GFD) among people with celiac disease who had followed the diet for at least 1 year.
February 20263
Long-Term Safety of Upadacitinib in Patients With Inflammatory Bowel Disease: Integrated Analysis of Phase 2/3 Studies.
This integrated safety analysis pooled six phase 2/3 trials of upadacitinib in patients with ulcerative colitis or Crohn’s disease.
Gastric fundal mucosal ablation followed by endoscopic sleeve gastroplasty in adults with obesity: a first-in-human two-phase pilot clinical trial.
This prospective, first-in-human, two-phase pilot clinical trial evaluated sequential gastric fundal mucosal ablation (GFMA) followed by endoscopic sleeve gastroplasty (ESG) in 10 adults with obesity.
Vagal Nerve Stimulation for Chronic Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and random-effects meta-analysis of six randomized controlled trials assessed transcutaneous auricular vagus nerve stimulation and transcutaneous electroacupuncture for chronic constipation.
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