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2000 articles
September 202624
Peritoneal Desmoplastic Small Round Cell Tumor on FDG PET/CT.
A 21-year-old man presented with intermittent abdominal pain and distension. Contrast-enhanced CT and 18F-FDG PET/CT showed diffuse peritoneal thickening and multiple hypermetabolic masses, prompting concern for…
A rare case of metastatic Merkel cell carcinoma presenting without a primary cutaneous lesion: A case report.
A 44-year-old male presented with a painless, enlarging mass in the right groin, with no prior skin lesions. Pathological examination confirmed metastatic Merkel cell carcinoma (MCC) through immunohistochemical…
Heparin-free veno-venous extracorporeal membrane oxygenation as a bridge therapy for airway interventions in malignant central airway obstruction: Case series and literature review.
Three patients with malignant central airway obstruction (MCAO) presented with severe respiratory failure due to bronchial obstruction from tumors.
Goal-directed nutritional support in preserving muscle mass and optimising recovery in treatment of oesophageal cancer: results of a prospective non-randomised cluster trial.
This prospective non-randomised cluster trial evaluated the impact of a goal-directed nutritional support protocol (GDNS) on muscle mass and survival in adults with oesophageal cancer undergoing neoadjuvant…
Late-onset immune checkpoint inhibitor-associated myocarditis: A systematic review and patient-level synthesis.
This PRISMA 2020 systematic review and patient-level synthesis examined the timing, clinical features, management and outcomes of immune checkpoint inhibitor-associated myocarditis presenting at least 90 days after the…
Arlocabtagene autoleucel: a GPRC5D-targeted CAR T-cell therapy for heavily pretreated relapsed/refractory multiple myeloma.
This phase 1 multicenter trial evaluated arlocabtagene autoleucel (arlo-cel), a CAR T-cell therapy targeting GPRC5D, in 84 adults with heavily pretreated relapsed/refractory multiple myeloma.
Expanding the Morphologic, Clinical, and Molecular Spectrum of Succinate Dehydrogenase A (SDHA)-Deficient Renal Cell Carcinoma: A Case Series With Review of Literature.
This multi-institutional case series examined five SDHA-deficient renal cell carcinomas (RCCs). Patients had a median age of 40 years, with male predominance.
'Posterior (SMA-first) Approach' Versus 'Standard Approach' in Terms of Resection Margin and Long-Term Survival After Pancreaticoduodenectomy for Periampullary and Pancreatic Carcinoma: A Randomized Trial.
This randomized controlled trial compared the SMA-first approach to the standard approach in pancreaticoduodenectomy for periampullary cancer.
Metastatic High-Grade Endometrial Stromal Sarcoma With ZC3H7B::BCOR Fusion in Pleural Fluid: A Case Report.
A 32-year-old woman presented with pelvic pain and a large uterine mass considered suspicious for leiomyosarcoma on MRI; imaging also showed pulmonary and vertebral lesions concerning for metastases.
Three dimensional printed patient-specific PEEK versus titanium mesh cage for anterior column reconstruction after spondylectomy for spinal tumours: a prospective controlled cohort study.
This prospective controlled cohort study compared subsidence rates at 12 months following vertebral body replacement (VBR) using 3D-printed patient-specific PEEK implants versus titanium mesh cages in adults with…
CEA-targeted fluorescence endoscopy for the detection of high-grade dysplasia and early invasive rectal cancer: A proof-of-concept trial.
This proof-of-concept clinical trial assessed whether carcinoembryonic antigen (CEA)-targeted near-infrared fluorescence imaging could distinguish advanced rectal polyps containing high-grade dysplasia or early invasive…
BRAF V600E-mutated marginal zone lymphoma may exhibit features that partially overlap with hairy cell leukemia.
This report describes two cases of BRAF-mutated marginal zone lymphoma (MZL), including a nodal MZL (NMZL) with a BRAF V600E mutation that exhibited partial morphologic and immunophenotypic overlap with hairy cell…
Prevalence of Claudin 18.2 Expression in Gastric and Gastroesophageal Junction Adenocarcinoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the prevalence of CLDN18.2 expression in gastric and gastroesophageal junction adenocarcinoma across 22 studies involving 12,173 patients.
Germline multigene panel testing for colorectal cancer: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis assessed germline multigene panel testing in unselected patients with colorectal cancer, pooling evidence from 21 eligible studies.
Sodium-glucose cotransporter-2 inhibitors and gastrointestinal neoplasm risk in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and gastrointestinal neoplasm risk in patients with type 2 diabetes mellitus (T2DM).
Comparative efficacy and safety of pharmacokinetically guided and body surface area-based 5-fluorouracil dosing in colorectal cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of pharmacokinetically guided versus body surface area (BSA)-based dosing of 5-fluorouracil (5-FU) in colorectal cancer.
Daraxonrasib for Previously Treated RAS -Mutant Non-Small-Cell Lung Cancer.
This phase 1-2 multicenter trial evaluated the safety and efficacy of daraxonrasib in 136 patients with previously treated RAS-mutant non-small-cell lung cancer (NSCLC).
Exercise for the mitigation of cancer therapy-related cardiac dysfunction in breast cancer patients treated with anthracyclines: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of long-term exercise on cancer therapy-related cardiac dysfunction (CTRCD) in breast cancer patients treated with anthracyclines.
Safety and Clinical Outcomes of a First-in-Human Trial of Point-of-Care Manufactured Trispecific CAR T Cells Targeting CD19, CD20, and CD22.
This phase I clinical trial evaluated the safety and efficacy of trispecific CAR T cells targeting CD19, CD20, and CD22 in 16 patients with relapsed/refractory B-cell malignancies.
Solitary Flat Bone Metastasis of Follicular Thyroid Carcinoma: Complete Molecular and Partial Structural Response After 2 131 I Therapies.
A patient with follicular thyroid carcinoma presented with a solitary metastasis in the right iliac bone, which remained structurally unchanged after two high-dose 131 I therapies.
A novel triple-knockout allogeneic BCMA CAR T-cell therapy (CT0590) for multiple myeloma: preclinical and phase 1 study.
This phase 1 clinical trial evaluated a novel allogeneic BCMA CAR T-cell therapy (CT0590) in 5 patients with relapsed and refractory multiple myeloma or primary plasma cell leukemia.
Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia.
This phase 2 randomized trial compared azacitidine plus venetoclax to induction chemotherapy in 172 previously untreated adults with acute myeloid leukemia (AML) eligible for induction.
Value of shear wave elastography in evaluating response to neoadjuvant chemotherapy in breast cancer: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of shear wave elastography in assessing the pathological response to neoadjuvant chemotherapy in breast cancer patients.
Patient-reported Outcomes and Healthcare Provider Perspectives on Subcutaneous Isatuximab Delivery via On-body Injector Versus Manual Injection: Results From the Phase 2 IZALCO Study in Relapsed/Refractory Multiple Myeloma.
The phase 2, multicenter, randomized IZALCO study assessed patient-reported outcomes and healthcare provider experiences with subcutaneous isatuximab delivered by on-body injector (OBI) or manual injection, alongside…
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