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1320 articles
August 202624
Association between lipoprotein-associated phospholipase A2 levels and risk of recurrent cerebrovascular events in patients with ischemic stroke: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and recurrent cerebrovascular events in 2,527 patients with ischemic stroke.
Prognostic effect of serum glial fibrillary acidic protein and neurofilament light chain for predicting progression independent of relapse activity in multiple sclerosis: A systematic review.
This systematic review evaluated the prognostic value of serum glial fibrillary acidic protein (sGFAP) and neurofilament light chain (sNfL) in predicting progression independent of relapse activity (PIRA) in multiple…
Clinical Reasoning: A 79-Year-Old Man With Subacute Onset Involuntary Facial Movements and Discoordination.
A 79-year-old man with metastatic Merkel cell carcinoma undergoing cancer-directed treatment was admitted to the hospital with 1 week of bilateral upper and lower extremity tremor and nearly continuous involuntary…
Pearls & Oy-sters: Bilateral Neuropathic Facial Pain With Autonomic Features and Neurovascular Contact.
A 35-year-old woman presented with severe bilateral facial pain in the V1 and V2 distributions, exacerbated by cosmetic product use and following a viral upper respiratory infection.
Outcomes of Intra-Arterial Tenecteplase after Endovascular Reperfusion for Acute Ischemic Stroke Due to Cardioembolism and Non-Cardioembolism: A Secondary Analysis of the POST-TNK Trial.
This secondary analysis of the POST-TNK randomized trial evaluated the safety and efficacy of intra-arterial tenecteplase (TNK) in 540 patients with acute ischemic stroke (AIS) due to cardioembolism (CE) and non-CE.
Spectrum of Neurofascin-155 Autoimmune Nodopathy in a Pediatric Cohort: A Single Center Experience.
This single-center pediatric case series described four patients with anti-neurofascin-155 autoimmune nodopathy. All had distal weakness and sensory loss; three also had tremor and sensory ataxia.
Clinical Profile, Electrophysiology, and Short-Term Outcomes of Pediatric-Onset Autoimmune Nodopathy-A Case Series.
The report describes three children with autoimmune nodopathy associated with antibodies to neurofascin 140, alone or with neurofascin 186.
Efficacy and tolerability of mirogabalin, pregabalin, duloxetine, and placebo in patients with type 2 diabetes mellitus and painful diabetic peripheral neuropathy: A network meta-analysis.
This network meta-analysis evaluated the efficacy and tolerability of mirogabalin, pregabalin, and duloxetine in treating painful diabetic peripheral neuropathy (PDPN) in patients with type 2 diabetes mellitus (T2DM).
Effects of brain-computer interface-based training on post-stroke lower limb rehabilitation: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of brain-computer interface (BCI) training on lower-limb rehabilitation post-stroke, analyzing ten randomized controlled trials with 366 participants.
Sigma-1 Receptor Ligand Blarcamesine (ANAVEX 2-73) for Alzheimer's Disease: A Systematic Review.
This systematic review evaluated the efficacy and safety of blarcamesine (ANAVEX 2-73) in early-stage and mild-to-moderate Alzheimer's disease (AD).
Blue light therapy delivered through light glasses improves sleep quality and daytime sleepiness in Parkinson's disease: A randomized trial.
This randomized controlled trial evaluated the effects of blue light therapy delivered through glasses on sleep quality and daytime sleepiness in individuals with Parkinson's disease.
Covert consciousness in behavioral coma.
An 80-year-old woman with acute severe traumatic brain injury presented with behavioral evidence of coma. Comprehensive evaluations using task-based fMRI and EEG revealed covert consciousness, indicating she could…
Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage: A Placebo-Controlled Trial.
This pilot randomized controlled trial evaluated the feasibility of colchicine for preventing vascular events after acute intracerebral hemorrhage (ICH) in adults with vascular risk factors.
A De Novo DHX16 Variant Associated With Neuromuscular Oculoauditory Syndrome Regulates Pre-mRNA Splicing In Vitro.
Neuromuscular oculoauditory syndrome (NMOAS; OMIM# 618733) is a rare neurodevelopmental disorder caused by heterozygous variants in DHX16, a gene in the DExD/H-box RNA helicase family.
Pediatric Cluster Headache Beyond Diagnostic Criteria: A Case Series and Review of Treatment Response.
The report describes four children—three boys and one girl—diagnosed with cluster headache, a disorder characterized by brief, unilateral pain around the eye with autonomic symptoms.
Carbamazepine-induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum: A Life-threatening Cutaneous Reaction in Epilepsy Management.
An adolescent female with epilepsy developed fever, sore throat, and mucocutaneous lesions within one week of starting carbamazepine.
Dose-Controlled Script Training for Aphasia: A Quasi-Randomized Pilot Clinical Trial Examining Treatment Frequency.
This quasi-randomized pilot clinical trial investigated the impact of treatment frequency on outcomes in 45 adults with chronic poststroke aphasia.
Expanding the Neurological Phenotype of ZTTK Syndrome: A Case of Recurrent Acute Confusional Migraine.
A child with Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome, a multisystem disorder associated with pathogenic SON variants, experienced recurrent episodes of acute confusional migraine (ACM).
An Adult Presentation of KIF11-Related MCLID Syndrome: Case Report and 40-Year Follow-Up.
A 42-year-old woman with severe intellectual disability had microcephaly, hypotonia, seizures, self-injurious behavior, developmental delays, ophthalmologic findings, and impaired speech and adaptive functioning.
Therapeutic local hypothermia in the management of acute spinal cord injury: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the safety and efficacy of local hypothermia in treating acute spinal cord injury (ASCI) across five studies involving 48 patients.
Trametinib-mediated MEK inhibition impairs cancer cell viability and invasion in patient-derived tumor avatars of glioblastoma with extraneural metastases: A proof-of-concept study.
A patient with glioblastoma (GBM) presented with rare extraneural metastases, characterized by aggressive molecular features including alterations in NF1, TP53, PTEN, and RB1.
High-frequency contralesional dorsal premotor cortex and low-frequency contralesional primary motor cortex rTMS in subacute stroke with severe upper limb impairment: comparable motor outcomes and differential regional degree centrality changes.
This randomized controlled trial evaluated the effects of high-frequency rTMS over the contralesional dorsal premotor cortex versus low-frequency rTMS over the contralesional primary motor cortex in 46 patients with…
Primary central nervous system T cell lymphoma involving multiple brain and spinal cord lesions with SETD2 mutation.
A 37-year-old Japanese man presented with impaired consciousness, and imaging revealed multiple contrast-enhancing lesions in the brain and spinal cord.
Guidelines for Seizure Prophylaxis in Patients with Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society.
This systematic review and meta-analysis informed Neurocritical Care Society guidance on antiseizure medication (ASM) prophylaxis in adults hospitalized with aneurysmal subarachnoid hemorrhage (SAH) and without prior…
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