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845 articles
May 202624
PRRX1::NCOA1 Rearranged Fibroblastic Tumour: A New Report With a Brief Literature Review of an Uncommon Neoplasm.
A case of a PRRX1::NCOA1 rearranged fibroblastic tumor was presented, characterized by a well-circumscribed, monomorphic cellular structure with oval to spindle-shaped cells.
A Periadrenal Gland Ewing Sarcoma With Extensive Posttreatment Ganglioneuroblastoma-Like Morphology in an Adult Patient.
A 33-year-old man presented with a retroperitoneal periadrenal mass, exhibiting features of Ewing sarcoma. Initial biopsy revealed small round cells with Homer-Wright rosettes and positive CD99 expression.
Clinicopathological Features and Outcomes of SMARCA4-Deficient Carcinomas of the Stomach and Gastroesophageal Junction: A Case Series and Literature Review.
This report details five patients with SMARCA4-deficient gastric cancer, characterized by aggressive behavior and advanced stage at diagnosis.
Acute generalized exanthematous pustulosis sine pustules.
The report describes AGEP presenting without clinically evident pustules, an atypical presentation that can complicate diagnosis when medication exposure is unclear or several drugs have been started close together.
Isolated Hepatic Cryptococcosis in an Immunocompetent Child: A Rare Cause of Granulomatous Hepatitis with Cholestasis.
A young immunocompetent child presented with fever, hepatomegaly, and cholestatic liver dysfunction. Liver biopsy showed preserved lobular architecture and prominent portal-based granulomas containing epithelioid…
Basaloid Squamous Cell Carcinoma of the Uterine Cervix: An Often Aggressive Subtype Frequently Underestimated by Cytology.
A case of basaloid squamous cell carcinoma (BSCC) of the cervix was initially misdiagnosed as a high-grade squamous intraepithelial lesion (HSIL) based on liquid-based cytology.
Using spaced repetition to teach histopathology significantly improves diagnostic skills: A randomized within-participant evaluation.
This randomized controlled trial evaluated the effectiveness of spaced repetition (SR) in enhancing diagnostic skills among 337 trainees and certified pathologists in histopathology.
Distinguishing Inverted Sinonasal Papilloma and Respiratory Epithelial Adenomatoid Hamartoma: A Single Institution Case Series.
Four patients presented with sinonasal masses initially suspected to be inverted sinonasal papilloma (ISP) based on intraoperative frozen sections.
Atypical Neurofibromatous Neoplasms of Uncertain Biological Potential in Children with Neurofibromatosis Type 1: Report of Two Patients and Review.
Two pediatric patients with Neurofibromatosis Type 1 (NF1) presented with rapidly enlarging peripheral nodules. The first patient, a 13-year-old boy, had a lumbogluteal nodule that showed growth despite treatment with…
Metaplastic Breast Carcinoma Hidden Behind a Melanocytic Facade: A Case Report with Literature Review on Metaplastic Breast Carcinoma with Melanocytic Differentiation.
A female patient in her late 20s presented with a breast tumor that exhibited melanocytic differentiation, leading to a challenging diagnostic process.
Fever, lymphadenopathy, and a diagnostic dilemma: a case of Kikuchi-Fujimoto disease masquerading as tuberculosis in a diabetic patient.
A middle-aged man with diabetes from South India presented with prolonged fever, substantial weight loss, and generalized lymphadenopathy.
Fatal splenic artery aneurysm rupture at medicolegal autopsy: A case series and review of the literature.
This case series examines six instances of fatal splenic artery aneurysm (SAA) rupture, highlighting the nonspecific clinical presentations that led to diagnostic delays.
Diagnosis of the Novel IASLC Grading System Using Intraoperative Frozen Section (ECTOP-1014): A Prospective, Multicenter Clinical Trial.
This prospective, multicenter clinical trial evaluated the accuracy of intraoperative frozen section in diagnosing IASLC grades in early-stage lung adenocarcinoma.
Mandibular malignant peripheral nerve sheath tumour in a patient with a history of radiotherapy for cerebellopontine angle ganglioneuroma.
A patient previously underwent subtotal resection and radiotherapy for a ganglioneuroma in the cerebellopontine angle region and later developed a malignant peripheral nerve sheath tumour (MPNST) in the mandible.
Primary Oral MALT Lymphoma Without Nodal or Systemic Involvement: A Rare Presentation.
A middle-aged patient presented with a slow-growing, asymptomatic oral lesion that was initially misidentified as an oral lipoma.
Inflammatory Myofibroblastic Tumor of the Breast Mimicking Complex Fibrocystic Changes, With a Novel CSTF3::ALK Fusion.
A 38-year-old woman presented with a 7-mm breast lesion classified as BI-RADS 3, initially suspected to be fibrocystic changes. Follow-up ultrasound revealed growth to 10 mm, leading to a core needle biopsy.
Primary Renal Sclerosing Epithelioid Fibrosarcoma With EWSR1::CREB3L1 Fusion: A Diagnostic Pitfall With a Comprehensive Review of Reported Patients.
Sclerosing epithelioid fibrosarcoma (SEF) is a rare malignant soft tissue sarcoma with morphologic and molecular overlap with low-grade fibromyxoid sarcoma (LGFMS).
Atypical Spitz Tumor With RET::MXT1 Gene Rearrangement in a 14-Year-Old Girl: An Integrated Histopathologic, Immunohistochemical, and Molecular Diagnostic Approach.
A 14-year-old girl presented with a changing pigmented lesion on her upper back. Histopathological analysis revealed an asymmetric melanocytic proliferation with epithelioid cells and limited mitotic activity.
Superficial Ewing Sarcoma of the Rectum: A Case Report and the Utility of Molecular Diagnostics.
A 38-year-old male presented with rectal bleeding and was found to have an ulcerated polyp near the dentate line. An excisional biopsy revealed a monotonous round cell malignancy with necrosis and high mitotic activity.
A Rare Case Report of Renal Hilar Teratoma Associated With a Well-Differentiated Neuroendocrine Tumor and High-Grade Upper Urinary Tract Urothelial Carcinoma.
A 70-year-old man presented with a renal hilar mature teratoma, which contained a well-differentiated neuroendocrine tumor alongside a high-grade upper urinary tract urothelial carcinoma.
Congenital Rapidly Progressive Perianal Embryonal Rhabdomyosarcoma With Spindle Cell Morphology: A Rare Presentation.
A 2-day-old male infant presented with a painless perianal swelling that progressively enlarged over two months. MRI revealed a 4.7 × 2.7 × 2.5 cm heterogeneous mass in the perineum extending into the pelvis.
Endometrial Endometrioid Carcinomas With Signet Ring Cells: Report of a Case Series With Detailed Clinical, Pathologic, and Molecular Analysis.
This case series described five patients aged 53–89 years who presented with postmenopausal bleeding and had endometrioid-type endometrial carcinomas containing signet ring cells.
Central nervous system involvement in multiple myeloma as a first manifestation of relapse and potential diagnostic pitfall.
In a review of 459 patients with multiple myeloma, four had cerebrospinal fluid involvement by malignant plasma cells. Three were in complete remission when CNS disease was detected.
NF2 -mutated Renal Cell Carcinoma: Clinicopathologic and Molecular Characterization of Two Additional Tumors Highlighting Morphologic Heterogeneity and Potential Aggressive Behavior.
Two female patients in their sixth decade presented with incidental solid renal masses measuring 3.2 cm and 3.0 cm. Both tumors exhibited high-grade nuclei and infiltrative growth, but with distinct architectural…
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