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2000 articles
November 202624
Imaging and Clinical Features of Secondary Spinal Cord Lymphoma: A 2-Center Case Series.
This two-center case series describes 18 cases of secondary spinal cord lymphoma. The authors examined spinal MRI findings and their relationship to intracranial disease, systemic lymphoma, and clinical features.
Zanubrutinib, obinutuzumab, and venetoclax in CLL: long-term follow up, MRD kinetics, retreatment, T-cell profiling, and PKs.
This phase 2 trial evaluated an MRD-guided course of zanubrutinib, obinutuzumab, and venetoclax (BOVen) in treatment-naïve chronic lymphocytic leukemia, including assessment of zanubrutinib–venetoclax retreatment and…
Duodenal Adenocarcinoma Recurrence Limited to the Choledochojejunostomy After Pancreaticoduodenectomy: A Case Suggesting Intraluminal Implantation With a Distinct Mucin Phenotypic Shift.
A 59-year-old man developed recurrence at the choledochojejunostomy 27 months after pancreaticoduodenectomy for duodenal adenocarcinoma, despite five surgically created raw surfaces.
Colonoscopy surveillance after colorectal cancer surgery: meta-analysis.
This systematic review and meta-analysis examined randomized trials comparing follow-up protocols with versus without colonoscopy within 5 years after colorectal cancer surgery.
Rare Sites of Metastases to the Breast and Integumentary System in Advanced Cervical Cancer at Initial Presentation in Eastern Uganda: A Case Report.
A 72-year-old woman in Uganda presented after 13 months of intermittent postmenopausal bleeding and abnormal vaginal discharge, despite repeated treatment for presumed urinary and sexually transmitted infections.
Oncologic efficacy and safety of stereotactic body radiotherapy for oligometastatic non-small cell lung cancer: a systemic meta-analysis.
This systematic review and meta-analysis assessed the efficacy and safety of stereotactic body radiotherapy (SBRT) for oligometastatic non-small cell lung cancer, including analyses by oligometastatic subtype and…
Variation in recommendations for management of pediatric fever and neutropenia across databases and languages: A systematic review of clinical practice guidelines.
This systematic review and content analysis examined evidence-based clinical practice guidelines (CPGs) for fever and neutropenia in children, assessing how database indexing and publication language affected guideline…
Sitagliptin, a repurposed diabetes drug, overcomes gemcitabine resistance in pancreatic cancer via ribonucleotide reductase inhibition: SITGEM-CARE phase 2 trial.
SITGEM-CARE was a single-center, phase 2 clinical trial evaluating sitagliptin with gemcitabine and nab-paclitaxel in 22 patients with locally advanced or metastatic pancreatic ductal adenocarcinoma.
Adjuvant mFOLFOXIRI after curative-intent resection of oligometastatic colorectal cancer: phase II FANTASTIC trial.
The multicentre, non-randomized phase II FANTASTIC trial evaluated adjuvant modified FOLFOXIRI after complete metastasectomy for oligometastatic colorectal cancer and assessed circulating tumour DNA (ctDNA).
Multidisciplinary Single Stage Surgical Management of Advanced Breast Carcinoma With Concomitant Left Atrial Myxoma.
A 58-year-old woman with locally advanced invasive mucinous breast carcinoma had a progressive fungating mass despite neoadjuvant chemotherapy and radiotherapy.
Angiosarcoma in the Setting of Vascular Procedures: A Systematic Review and Our Experiences.
Angiosarcoma is a rare, aggressive endothelial malignancy with a poor prognosis; diagnosis is often delayed by vague symptoms, nonspecific imaging, and challenging histopathology.
Coronary artery calcification is not associated with survival in advanced gastric and gastroesophageal junction cancer: a secondary analysis of the EXPAND trial.
This secondary analysis of baseline CT images from the phase III EXPAND trial assessed whether coronary artery calcification (CAC) predicted overall survival in 785 patients with unresectable locally advanced or…
Catatonic signs during delirium in leptomeningeal melanoma: Treatment trade-offs in end-of-life care.
A man in his late 30s with metastatic melanoma involving the leptomeninges and brain developed fluctuating arousal, inattention, disorientation, mutism, immobility, staring, withdrawal, and waxy flexibility.
Sex difference in survival benefits of immune checkpoint inhibitors in advanced non-small cell lung cancer: A meta-analysis.
This random-effects meta-analysis examined sex-stratified survival outcomes from 42 phase 3 randomised trials comparing immune checkpoint inhibitors (ICIs) with chemotherapy in advanced non-small cell lung cancer.
A phase Ia first-in-human study of BPB-101, a novel trifunctional antibody targeting the GARP/TGF-β complex and PD-L1, in patients with locally advanced or metastatic solid tumors.
This phase Ia, multicenter, first-in-human dose-escalation study evaluated BPB-101, a trifunctional antibody targeting the GARP/TGF-β complex and PD-L1, in previously treated patients with advanced or metastatic solid…
Concomitant Robotic Pericardial Window and Mediastinal Tumour Biopsy Under Intraoperative Ultrasound Guidance.
An 83-year-old woman presented with an undiagnosed mediastinal mass and a symptomatic, loculated pericardial effusion. She underwent a robotic pericardial window and mediastinal tumour biopsy performed together under…
Children of advanced cancer patients need better support: A case report.
This case study describes a parent with advanced cancer and minor children who needed support in discussing the diagnosis, preparing the children for the possibility of death, and addressing anticipatory grief.
Spatial Acid-Associated Niches Inform Irinotecan-Based DEB-TACE in Colorectal Liver Metastases: A Multicentre Randomized Trial.
This multicentre randomised trial combined transcriptomic and spatial analyses of colorectal liver metastases (CRLM), laboratory testing of irinotecan-eluting microspheres, and clinical evaluation in 35 patients with…
TIM3 Blockade with Hypomethylating Therapy Restores NK Cell and Cytotoxic CD4+ T-cell Activity in Patients with AML or MDS.
This phase Ib clinical trial examined immune changes in patients with AML or MDS treated with anti-TIM3 sabatolimab plus decitabine.
Pediatric suprasellar primary CNS lymphoma with cavernous sinus invasion and ischemic stroke: a case report and systematic review.
A 12-year-old immunocompetent girl presented with high fever, severe headache, and diplopia, followed by rapid neurological deterioration.
A Phase II Trial of Pembrolizumab plus Granulocyte-Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer.
This single-center phase II trial evaluated pembrolizumab plus GM-CSF in 42 patients with advanced biliary cancers previously treated with chemotherapy and without prior immune checkpoint inhibitor therapy.
A Phase I First-Time-in-Human, Open-label Study of Nelistotug Administered to Patients with Advanced Solid Tumors.
This first-in-human, open-label, nonrandomized, multicenter phase I study evaluated nelistotug, an anti-CD96 antibody, alone or with dostarlimab, and in a three-drug combination with dostarlimab and belrestotug in…
Neoadjuvant PD-L1/TGF-β blockade can rapidly disrupt the tumor stroma in head and neck cancer patients.
This window-of-opportunity clinical study examined neoadjuvant bintrafusp alfa, a dual PD-L1 and TGF-β inhibitor, in patients with head and neck squamous cell carcinoma.
Safety and Efficacy of Intratumoral MEDI1191, an IL12 mRNA Lipid Nanoparticle, plus Intravenous Durvalumab in Patients with Advanced Solid Tumors: A First-in-Human Study.
This open-label, multicenter, first-in-human phase I dose-escalation study evaluated intratumoral MEDI1191, an IL-12 mRNA lipid nanoparticle, with intravenous durvalumab in adults with advanced or metastatic solid…
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