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1320 articles
September 202622
Late-Onset Tay-Sachs Disease With SMALED-Like Muscle MRI Pattern Despite a Distinct Clinical Phenotype.
Two female patients in their second decade presented with slowly progressive, lower limb-predominant flaccid weakness and tremor.
Long-Term Safety and Efficacy of Efgartigimod PH20 in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: ADHERE/ADHERE+ Trial Interim Analysis.
The ADHERE/ADHERE+ trial evaluated the long-term safety and efficacy of efgartigimod PH20 in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
Amyloid-Like Immunoglobulin Deposition Neuropathy.
A case of amyloid-like immunoglobulin deposition neuropathy was presented, characterized by predominant neuropathic pain, skin changes, and progressive distal sensory neuropathy.
Boy in the Barrel: Excruciating Paroxysmal Pain Disorder Associated With an SCN9A Gain-of-Function Variant.
A young man presented with severe childhood-onset paroxysmal pain triggered by heat, alongside autonomic dysfunction and skeletal abnormalities.
Epilepsy-Related Psychosis in Drug-Resistant Epilepsy With Nonconvulsive Status Epilepticus and Difficult Antipsychotic Titration: A Case Report.
A man in his late 50s with drug-resistant epilepsy and recurrent psychosis presented with reduced responsiveness and fluctuating alertness during medication adjustment.
Ketone Bodies Derived From Medium-Chain Triglycerides Support Brain Metabolism and Function Under Hypoglycemia in Type 1 Diabetes Mellitus.
This randomized controlled trial investigated the effects of medium-chain triglycerides (MCTs) on brain metabolism during hypoglycemia in individuals with type 1 diabetes mellitus (T1DM).
Looking Beyond the Midline: An Uncommon Etiology of Internuclear Ophthalmoplegia of Abduction Due to Cerebral Venous Thrombosis.
A 27-year-old man presented with headache, vomiting, seizures, and altered sensorium. Examination revealed bilateral disc edema and abduction restriction of the right eye, consistent with internuclear ophthalmoplegia…
Acute Spinal Cord Infarct Secondary to Fibrocartilaginous Embolism Treated With Tenecteplase.
A 56-year-old male with hypertension experienced sudden left arm and leg weakness following a Valsalva maneuver. Examination revealed dense flaccid paralysis.
De Novo MFN2 p.Arg95Met in Severe Charcot-Marie-Tooth Disease Type 2A.
A 30-year-old Taiwanese woman presented with severe axonal sensorimotor neuropathy, characterized by early-onset weakness, distal wasting, optic atrophy, and bilateral sensorineural hearing loss.
Blood pressure parameters and cognitive decline and dementia after stroke or transient ischemic attack: results from the PROGRESS trial.
This randomized controlled trial analyzed blood pressure parameters in 5128 participants with stroke or transient ischemic attack from the PROGRESS trial.
A Phase I and Biodistribution Study of Ifabotuzumab, a Humanized Agonistic EphA3-Targeted Antibody, in Patients with Recurrent Glioblastoma.
This Phase I multicenter study evaluated the safety and biodistribution of ifabotuzumab, an EphA3-targeted antibody, in 12 adults with recurrent glioblastoma.
The effects of neuromodulation through brainwave entrainment on pain in women with fibromyalgia: a randomized controlled clinical trial with follow-up.
This randomized controlled trial examined the effects of brainwave entrainment (BWE) versus music therapy on pain management in 84 women with fibromyalgia.
Case Report: Post-Bomb Explosion Epilepsy.
This case report details two patients who developed post-traumatic epilepsy following exposure to explosive blasts in war zones.
Results From a Phase 2, Open-Label Study Evaluating the Safety, Tolerability, and Effect on Ataxia of GLM101 in Three Adult Patients With PMM2-CDG.
Phosphomannomutase 2 congenital disorder of glycosylation (PMM2-CDG) is a rare, autosomal recessive disease caused by PMM2 deficiency, which impairs conversion of mannose-6-phosphate into mannose-1-phosphate (M1P) and…
Efficacy and Durability of Repetitive Transcranial Magnetic Stimulation on Cognitive Function in Patients With Mild-to-Moderate Alzheimer's Disease: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in 143 patients with mild to moderate Alzheimer's disease.
Prevalence of unruptured intracranial aneurysms according to comorbidities, risk factors, country, and time period: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the prevalence of unruptured intracranial aneurysms (UIAs) across various comorbidities and risk factors, analyzing data from 316,131 participants.
Individual differences in brain dynamics across a social cognition network induced by cortico-cerebellar tDCS in adults with autism spectrum disorder (ASD).
This randomized controlled trial investigated the effects of cortico-cerebellar transcranial direct current stimulation (tDCS) on brain dynamics in 24 young adults with autism spectrum disorder (ASD).
Endovascular therapy for mild-to-moderate stroke due to basilar artery occlusion: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of endovascular therapy (EVT) for patients with mild-to-moderate stroke due to basilar artery occlusion (BAO) and NIHSS <10.
Plasma Biomarker Effects of Oral Valiltramiprosate/ALZ-801 in Early Alzheimer's Disease from Phase 3 and Phase 2 Trials: Analysis of Core Biomarkers and Correlations with Clinical and Neuroimaging Outcomes.
This study analyzed plasma biomarkers in APOE4 homozygotes with early Alzheimer's disease from Phase 3 and Phase 2 trials of valiltramiprosate/ALZ-801.
Effect of citicoline on cognitive function and functional recovery in patients with mild-to-moderate traumatic brain injury: a randomized placebo-controlled trial.
This randomized, placebo-controlled trial assessed the impact of citicoline on cognitive and functional recovery in 60 adults with mild-to-moderate traumatic brain injury (TBI).
A systematic review of electrophysiological markers of reward processing in addiction.
This systematic review examined EEG event-related potential markers of reward anticipation and outcome processing in adults with substance use disorders or behavioral addictions, compared with healthy controls.
FGF14 (GAA) repeat expansion-associated Ataxia (SCA27B): Expanding the clinical and diagnostic spectrum from the first genetically confirmed case in Argentina.
An Argentinean patient with late-onset ataxia was initially diagnosed with alcoholic cerebellar degeneration. Genetic testing identified an FGF14 GAA repeat expansion, confirming spinocerebellar ataxia 27B (SCA27B).
August 20262
Systematic Review of Pharmacologic Treatment for Migraine Prevention in Adults: Report of the AAN Guidelines Subcommittee and the American Headache Society.
This systematic review evaluated pharmacologic treatments for migraine prevention in adults, analyzing 217 randomized controlled trials.
Treatment of multiple sclerosis with peptide-coupled red blood cells induces antigen-specific T regulatory cells.
This phase Ib clinical trial evaluated the safety and efficacy of peptide-coupled red blood cells (pcRBCs) in patients with multiple sclerosis (MS).
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