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1303 articles

August 202611

Clinical ResearchPsychiatry

Optimising and personalising task-shared psychosocial interventions for common mental disorders: a Bayesian component network meta-analysis of individual participant data.

This Bayesian component network meta-analysis evaluated the efficacy of individual components of task-shared psychosocial interventions for common mental disorders in adults.

Lancet PsychiatryAug 3, 2026Read summary
Clinical ResearchPsychiatry

Psychotherapy training in psychiatry: a systematic review and narrative synthesis on the supervision experiences of early-career psychiatrists.

This systematic review examined the supervision experiences of early-career psychiatrists (ECPs) in psychotherapy training, analyzing 29 studies with 4691 participants.

Psychiatry ResAug 3, 2026Read summary
Clinical ResearchPsychiatry

Adjunctive nutritional interventions in schizophrenia: A systematic review of randomised clinical trials.

This systematic review evaluated the effectiveness of nutritional interventions in schizophrenia, analyzing nine randomized clinical trials.

Clin Nutr ESPENAug 3, 2026Read summary
Clinical ResearchOncology (Medical)

Safety and Efficacy of Psilocybin During Anticancer Treatment: A Phase II Trial Secondary Analysis.

This phase II trial secondary analysis evaluated the safety and efficacy of psilocybin-assisted therapy in cancer patients with major depressive disorder, comparing those receiving systemic anticancer treatment to those…

J Pain Symptom ManageAug 3, 2026Read summary
Clinical ResearchPsychiatry

Targeting pain to improve opioid use disorder treatment outcomes: Results of a randomized trial.

This randomized trial tested whether adding telehealth psychosocial pain management to buprenorphine improved outcomes for 200 adults with opioid use disorder and pain lasting at least 3 months.

J Subst Use Addict TreatAug 3, 2026Read summary
Clinical ResearchPsychiatry

Anterior cingulate cortex alterations in children and adolescents with Attention Deficit and Hyperactivity Disorder: a systematic review of neuroimaging studies.

This systematic review examines neuroimaging studies of the anterior cingulate cortex (ACC) in children and adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD).

Nord J PsychiatryAug 2, 2026Read summary
Clinical ResearchPsychiatry

Promoting smoking cessation and preventing relapse to tobacco use following a smokefree mental health in-patient stay: A multi-centre randomised controlled feasibility study.

This multicentre, individually randomised feasibility trial assessed a 12-week smoking-cessation support programme for adults who smoked during or after admission to acute mental health wards in six English NHS trusts…

AddictionAug 2, 2026Read summary
Clinical ResearchPsychiatry

Sexual and gender minority youth experience serious mental health risks, yet are not impacted by typically efficacious interventions: secondary mental health outcomes from randomized controlled trial (ATN 149).

This randomized controlled trial assessed secondary mental health outcomes of three HIV-prevention intervention components—automated text messaging, online peer support, and strengths-based coaching—in 895 sexual and…

J Child Psychol PsychiatryAug 2, 2026Read summary
Clinical ResearchInternal Medicine (General)

Frequent readmissions after hospitalization for alcohol withdrawal: a systematic review and meta-analysis.

This systematic review and meta-analysis examined readmission rates after inpatient detoxification for alcohol use disorder. Among 25 studies, the pooled readmission rate was 17% within 1 month and 44% within 1 year.

Addict BehavAug 1, 2026Read summary
Clinical ResearchPsychiatryOpen access

The Effectiveness of Dialectical Behavior Therapy in Reducing Self-Directed Violence and Suicidality in Usual Care Settings: A Meta-Analysis.

This meta-analysis evaluated the effectiveness of Dialectical Behavior Therapy (DBT) in reducing self-directed violence (SDV), crisis service use (CSU), and suicidal ideation (SI) in usual care settings.

J Clin PsycholAug 1, 2026Read summary
Clinical ResearchPsychiatry

Peripheral toll-like receptor expression indicates distinct innate immune signatures in schizophrenia spectrum and mood disorders: A systematic review and meta-analysis.

This systematic review and meta-analysis examined peripheral blood mRNA expression of TLR1–TLR10 in schizophrenia spectrum disorders (SSD) and mood disorders compared with healthy controls.

Brain Behav ImmunAug 1, 2026Read summary

July 202613

Clinical ResearchPsychiatry

Polygenic risk scores in major depressive disorder: A systematic review across diagnostic, treatment, course/severity, and subtype domains.

This systematic review examined the role of polygenic risk scores (PRS) in major depressive disorder (MDD) across various domains, including diagnosis and treatment.

J Affect DisordJul 31, 2026Read summary
Clinical ResearchPsychiatryOpen access

Evaluating the association between potentially morally injurious events (PMIEs) and types of psychological distress. A systematic review.

This systematic review analyzed 15 quantitative studies involving approximately 21,700 participants to explore the relationship between different subtypes of potentially morally injurious events (PMIEs) and…

Eur J PsychotraumatolJul 31, 2026Read summary
Clinical ResearchPsychiatryOpen access

PDE10A Inhibition in Schizophrenia: A Randomised, Placebo-Controlled Phase 2 Study of Alofropodect (CPL'36) in Patients Experiencing Acute Schizophrenia.

This phase 2, randomized, double-blind, placebo-controlled trial evaluated the efficacy of alofropodect, a PDE10A inhibitor, in 189 hospitalized patients with acute schizophrenia.

CNS DrugsJul 31, 2026Read summary
Clinical ResearchPsychiatry

Emotion regulation and insomnia as candidate processes of change in a digital mental health intervention.

This randomized controlled trial evaluated the ETUCARE digital mental health intervention among 1064 French university students, focusing on emotion regulation and insomnia as processes of change.

Behav Res TherJul 31, 2026Read summary
Clinical ResearchCardiology

Psychotherapy vs antidepressants in heart failure: Impact of adherence.

This randomized controlled trial evaluated the effects of behavioral activation (BA) versus antidepressant medication (MEDS) on patients with heart failure (HF) and depression, focusing on treatment adherence.

J Affect DisordJul 30, 2026Read summary
Clinical ResearchMedical Genetics

Genetic evidence for a causal relationship between melatonin metabolism and depression.

This systematic review utilized two-sample Mendelian randomization to explore the causal relationship between melatonin metabolism and specific depression symptom subtypes in major depressive disorder (MDD).

J Affect DisordJul 30, 2026Read summary
Clinical ResearchNeurology

Longitudinal neuropsychological safety assessment of biperiden treatment following traumatic brain injury.

This randomized controlled trial assessed the neuropsychological safety of biperiden in 54 patients with moderate-to-severe traumatic brain injury (TBI).

Exp NeurolJul 30, 2026Read summary
Clinical ResearchPsychiatry

Indiscriminate trauma preventions may discriminate: A randomised controlled trial of group psychological first aid.

This randomized controlled trial evaluated the effectiveness of Psychological First Aid (PFA) in reducing psychological distress after trauma in 84 participants.

Behav Res TherJul 30, 2026Read summary
Clinical ResearchPsychiatry

Neuroimaging anxious children and adolescents before and after cognitive behavioral therapy: a systematic review.

This systematic review examined neuroimaging studies of youths under 19 with anxiety disorders undergoing cognitive behavioral therapy (CBT).

Psychiatry Res NeuroimagingJul 30, 2026Read summary
Clinical ResearchPsychiatry

Short-term psychodynamic psychotherapy for functional neurological disorder: A pilot randomized controlled trial.

This pilot randomized controlled trial evaluated the efficacy of Short-term Psychodynamic Psychotherapy (STPP) combined with Standard Medical Care (SMC) in adults with Functional Neurological Disorder (FND).

Clin Neurol NeurosurgJul 30, 2026Read summary
Clinical ResearchPsychiatry

Depression and amyloid-β across CSF, PET, and plasma biomarkers: a systematic review and meta-analysis.

This systematic review and meta-analysis examined the relationship between amyloid-β biomarkers and depression in adults, analyzing 24 studies across cerebrospinal fluid, PET, and plasma sources.

NeuroscienceJul 30, 2026Read summary
Clinical ResearchPsychiatry

Body, Emotions, and Hormones: A Systematic Review of Body Dissatisfaction, Emotion Regulation, and Puberty in Adolescence.

This systematic review examined how puberty, emotion regulation, and body dissatisfaction relate in young people aged 6–18. Searches of five databases identified 103 studies for data extraction from 3,658 records.

J AdolescJul 30, 2026Read summary
Clinical ResearchPsychiatry

Mindfulness-based interventions for opioid misuse: A systematic review of randomized controlled trials.

This systematic review assessed randomized controlled trials of mindfulness-based interventions (MBIs) in adults with opioid misuse or opioid use disorder.

J Subst Use Addict TreatJul 30, 2026Read summary

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