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1382 articles
August 202624
Case report: compound heterozygous PTH1R variant(s) in a patient with inactivating PTH/PTHrP signalling disorder type 1 (iPPSD1).
A 9-year-old girl from the Indian subcontinent presented with primary failure of tooth eruption, dental anomalies, valgus deformity, PTH resistance, and subclinical hypothyroidism.
GH-IGF-1 axis and rhGH outcomes in children with GHD, ISS and SGA: a systematic review and meta-analysis.
This systematic review and meta-analysis compared GH–IGF-1 profiles and recombinant human growth hormone (rhGH) outcomes in children with growth hormone deficiency (GHD), idiopathic short stature (ISS), or persistent…
Stepwise low-pressure VAC for deep sternal infection in a 2.8-kg infant.
A 2-month-old, 2.8-kg boy developed a deep sternal wound infection after repair of an atrial septal defect, ventricular septal defect, and patent ductus arteriosus.
Emergent Reversal of Intracranial Hemorrhage Using 4-Factor Prothrombin Complex Concentrate in a Pediatric Patient.
An 11-year-old male with sinusitis complicated by multifocal intracranial abscesses and a superior sagittal sinus thrombus was treated with rivaroxaban.
Dulaglutide vs insulin in adolescents with thalassaemia-induced diabetes: effect on metabolism and atherogenesis (DIADEMA).
The DIADEMA trial compared dulaglutide to insulin in adolescents (10-18 years) with thalassaemia-induced diabetes. After 24 weeks, dulaglutide significantly reduced glycaemic variability (CV decreased from 39.45% to…
Comparative Efficacy, Safety, and Cost of Different Intrapleural Fibrinolytic Agents for the Management of Empyema Thoracis in Children: A Systematic Review.
This systematic review aimed to evaluate the efficacy, safety, and cost of intrapleural fibrinolytic agents for pediatric empyema thoracis.
Identification and characterisation of a novel homozygous KDM5A variant associated with severe axial hypotonia, seizures, and cardiac anomalies.
A patient with severe neurodevelopmental delay had neuromotor delay, profound axial hypotonia with absent head control, mild upper-limb spasticity, a history of seizures, facial dysmorphism and congenital heart disease.
Report of Mucopolysaccharidosis Type VI Disorder in Pakistani Patients Presenting Two Novel ARSB Variants.
Two unrelated Pakistani patients were evaluated for mucopolysaccharidosis type VI (MPS-VI), an inherited disorder caused by deficient arylsulfatase B activity.
Classroom microbiome signatures of pest management associate with reduced asthma symptoms.
This ancillary study of a randomized, placebo-controlled trial examined whether school-based integrated pest management (IPM) altered classroom microbiomes and whether intervention-associated microbial signatures…
Multisystem Inflammatory Syndrome Therapies in Children: A Comparative Effectiveness Trial.
This two-hospital comparative effectiveness trial evaluated infliximab, methylprednisolone, and anakinra in children with intravenous immunoglobulin (IVIG)-resistant multisystem inflammatory syndrome (MIS-C).
Reflective functioning skills mediating the relationship between attachment security and therapeutic alliance in mentalization-based treatment for children.
This study examined whether pre-treatment attachment security and reflective functioning (RF) were associated with early therapeutic alliance among 71 children aged 7–12 receiving Mentalization-Based Treatment for…
Prevalence and risk factors of nutritional anaemia among adolescents in India: a systematic review with meta-analysis of prevalence.
This systematic review and meta-analysis assessed the prevalence of nutritional anaemia among Indian adolescents aged 10-19 years, analyzing data from 45 studies involving 159,979 participants.
Pediatric Gastric GIST With SDHA Truncation Despite Retained SDHB Staining: A Case Report.
A 14-year-old boy presented with a gastric GIST, which was positive for KIT and DOG1. Genetic analysis revealed a truncating variant in the SDHA gene, indicating SDH deficiency.
Pediatric Mangled Injury.
A pediatric patient sustained a complex upper extremity injury from a motor vehicle accident, involving brachial plexus injury, vascular compromise, bony injury, and denervated muscles.
Effects of attenuated influenza virus administration to young children on pneumococcal density and acquisition in UK families: a randomised controlled trial.
This randomized controlled trial investigated the effects of live attenuated influenza vaccine (LAIV) on pneumococcal density and acquisition in young children and their household contacts in the UK.
Baseline diet quality indicators and 6-month changes in iron and vitamin A biomarkers among rural Ghanaian adolescent schoolgirls: A secondary analysis of the Ten2Twenty-Ghana trial.
This secondary analysis of the Ten2Twenty-Ghana randomized controlled trial examined the relationship between baseline diet quality and changes in iron and vitamin A biomarkers among 300 rural Ghanaian adolescent girls…
Pediatric Postoperative Acute Kidney Injury After Noncardiac Surgery: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the incidence of postoperative acute kidney injury (AKI) in children undergoing noncardiac surgery, analyzing data from 27 studies with 21,908 patients.
Circulating MicroRNAs as Diagnostic and Prognostic Biomarkers for Neuroblastoma: A Systematic Review and Exploratory Re-analysis.
This systematic review and exploratory re-analysis assessed circulating microRNAs as diagnostic and prognostic biomarkers in patients with neuroblastoma. Nine studies involving 385 patients were included.
Severe self-injury in a young girl with autism spectrum disorder and Helsmoortel-van der Aa syndrome responding to naltrexone.
A 10-year-old nonverbal girl with autism spectrum disorder and Helsmoortel-van der Aa syndrome had chronic, severe self-injurious behavior (SIB), including ocular rupture.
Pineoblastoma in a 5-Year-Old Male: A Case Report and Review of Literature.
A 5-year-old male presented with symptoms indicative of raised intracranial pressure. Imaging studies identified a tumor in the pineal region, which was confirmed as pineoblastoma through histopathological evaluation.
Bridging Resource Gaps in Toxic Epidermal Necrolysis Management: A Case Report Highlighting Innovative Care.
A 2-year-old girl presented with a 6-day history of fever and a rash that progressed to extensive exfoliation of over 70% of her body surface area after starting amoxicillin and clavulanic acid.
Early Ictal Dynamics in Childhood Absence Epilepsy: Scalp EEG Detection of Direct Current Shifts and High-Frequency Oscillations.
Two children with childhood absence epilepsy had typical absence seizures during hyperventilation-provoked scalp EEG. Wide-band recordings captured both direct-current (DC) shifts and high-frequency oscillations (HFOs)…
Effects of combined virtual reality assisted gait training and proprioceptive neuromuscular facilitation on motor function in children with spastic cerebral palsy: a randomized controlled trial.
This exploratory randomized controlled trial compared conventional rehabilitation, virtual reality (VR)-assisted gait training, and combined VR and proprioceptive neuromuscular facilitation (PNF) in 30 children with…
Effects of Peer-Based Experiential Education on Psychosocial Adaptation in Adolescents with Type 1 Diabetes: A Randomized Controlled Trial.
This parallel-group randomized controlled trial evaluated a seven-week peer-based experiential education program in 46 adolescents aged 13–18 years with type 1 diabetes and suboptimal glycemic control (HbA1c > 7.5%).
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