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1240 articles
August 202624
Effects of semaglutide and empagliflozin on markers of endothelial function in persons with type 2 diabetes: A post hoc analysis of a randomized clinical trial.
This post-hoc analysis of a 32-week randomized trial evaluated the effects of semaglutide and empagliflozin on endothelial function markers in 120 participants with type 2 diabetes.
Prothrombin complex concentrate (PCC) vs. non-PCC strategies for warfarin reversal in left ventricular assist device recipients: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated prothrombin complex concentrate (PCC) versus non-PCC strategies for warfarin reversal in left ventricular assist device (LVAD) recipients.
Complete Revascularization Guided by Functional Coronary Angiography in STEMI.
This randomized controlled trial evaluated the effectiveness of complete coronary-artery revascularization guided by functional coronary angiography versus conventional angiography in patients with STEMI and multivessel…
Effects of acute and short-term grape seed extract supplementation on blood pressure responses to exercise in individuals at cardiometabolic risk: A randomised, double-blind, placebo-controlled exploratory crossover trial.
This randomized, double-blind, placebo-controlled crossover trial examined the effects of grape seed extract (GSE) supplementation on blood pressure responses to exercise in ten sedentary adults with elevated blood…
Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults.
This randomized controlled trial evaluated the effects of atorvastatin on cardiovascular events and disability-free survival in 9971 community-dwelling adults aged 70 and older without prior cardiovascular disease.
Effect of Aficamten on Cardiac Structure and Function in Patients With Symptomatic Nonobstructive Hypertrophic Cardiomyopathy.
This prespecified exploratory analysis of the phase 3, multicentre, randomised, placebo-controlled ACACIA-HCM trial examined serial echocardiographic changes in symptomatic patients with nonobstructive hypertrophic…
Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event.
This phase 3, multicentre, randomised, placebo-controlled trial tested milvexian added to standard antiplatelet therapy in patients treated within 7 days after an acute coronary syndrome event.
Safety and efficacy of the 0/1 h pathway for myocardial infarction in the emergency department: an international, pragmatic, stepped-wedge, cluster-randomised, controlled trial.
This international, pragmatic, stepped-wedge, cluster-randomised controlled trial compared implementation of the 0/1 h versus 0/3 h high-sensitivity troponin pathway in adults presenting to emergency departments with…
Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain.
This multicenter randomized controlled trial compared outpatient CT coronary angiography-guided care with standard care in emergency-department patients whose myocardial infarction had been ruled out but whose…
Prasugrel versus Ticagrelor in Acute Coronary Syndromes.
This registry-based, open-label, stepped-wedge cluster-randomized trial compared default prasugrel and ticagrelor policies among adults in Sweden who underwent percutaneous coronary intervention for acute coronary…
Safety and lipoprotein(a)-lowering effects of Kylo-11, a non-canonical, long-duration small interfering RNA targeting lipoprotein(a): a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial.
This phase 1, randomized, double-blind, placebo-controlled trial evaluated the safety and lipoprotein(a)-lowering effects of Kylo-11 in 71 healthy adults aged 18-55 with elevated lipoprotein(a).
Bivalirudin Versus Heparin in Low and Non-Low Bleeding Risk Patients Undergoing Primary PCI for STEMI: The BRIGHT-4 Trial.
The BRIGHT-4 trial, a randomized controlled trial involving 6,016 STEMI patients undergoing primary PCI, compared bivalirudin with heparin.
Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk.
This multicenter randomized controlled trial evaluated the efficacy of direct oral anticoagulant (DOAC) therapy in patients with atrial fibrillation at intermediate stroke risk in South Korea.
A Pascal in ring: Transcatheter edge-to-edge tricuspid repair for severe regurgitation within a surgical annuloplasty ring.
A 69-year-old woman with a history of rheumatic heart disease and multiple cardiac surgeries presented with heart failure due to severe tricuspid regurgitation from leaflet restriction within a surgical annuloplasty…
Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM.
This randomized, placebo-controlled trial analysis assessed multiple treatment responses to aficamten in symptomatic patients with nonobstructive hypertrophic cardiomyopathy (nHCM), using outcomes measured at week 36.
Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis.
This international, open-label randomized trial compared response-tailored with standard-duration antibiotic therapy in clinically stable adults with left-sided infective endocarditis caused by Staphylococcus aureus…
Vitamin K 2 and D 3 Supplementation in Patients With Severe Coronary Artery Calcification: The DANCODE Trial.
The multicenter, double-blind, placebo-controlled DANCODE randomized trial tested vitamin K₂ (720 μg/d) plus vitamin D₃ (25 μg/d) for 24 months in adults with severe coronary artery calcification (CAC score ≥400…
Skeletal muscle index modulates the reduction of aortic pressure augmentation after foam rolling.
This randomized crossover study examined acute vascular responses to foam rolling in 26 men and women aged 22–62 years, comparing 20 minutes of foam rolling with sham control on separate days.
Changes in Composite Cardiovascular Risk Scores from Childhood to Adulthood and Cardiometabolic Outcomes in Adulthood: A Systematic Review.
This systematic review synthesised population-based longitudinal studies examining how composite cardiovascular risk scores change from childhood to adulthood and relate to adult cardiometabolic outcomes.
Transcatheter Aortic Valve Replacement or Medical Treatment for Paradoxical Low-Flow, Low-Gradient Aortic Valve Stenosis: REBOOT-PARADOX.
REBOOT-PARADOX was a multicenter, open-label randomized trial comparing TAVR plus optimal medical therapy (OMT) with OMT alone in symptomatic patients with paradoxical low-flow, low-gradient aortic stenosis and…
Patient-reported outcome measures for depression or anxiety symptoms in patients with cardiovascular disease: A COSMIN systematic review.
This systematic review evaluated the methodological quality and measurement properties of patient-reported outcome measures (PROMs) for depression and anxiety in adults with cardiovascular disease (CVD).
Efficacy of sodium-glucose cotransporter 2 inhibitors after acute myocardial infarction: Are the benefits limited to patients with diabetes? A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients post-acute myocardial infarction (AMI).
HFpEF-ABA Score and Finerenone in Patients With Heart Failure and Mildly Reduced or Preserved Ejection Fraction: Insights From the FINEARTS-HF Trial.
This analysis of the randomized, placebo-controlled FINEARTS-HF trial assessed the HFpEF-ABA score in patients with heart failure and left ventricular ejection fraction ≥40%, including its association with outcomes and…
Effects of home-based isometric handgrip or aerobic training on blood pressure variability and vascular health in older adults with elevated blood pressure and hypertension: secondary results from The HoldAge Trial.
This two-center prospective randomized controlled trial examined whether home-based isometric handgrip training (IHT) or aerobic exercise training (AET) affected blood pressure variability and vascular health in 84…
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