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1357 articles
October 202624
Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease.
This prospective, parallel-group randomized controlled trial assessed a 12-week telehealth-supported home exercise program in adults aged ≥45 years with non-dialysis stage 4-5 chronic kidney disease.
Associated factors for stress ulcers and gastrointestinal bleeding in patients with sepsis or septic shock: A systematic review.
This systematic review synthesized observational cohort and case-control studies of factors associated with stress ulcers or significant gastrointestinal bleeding in adults with sepsis or septic shock.
Oral Potassium Supplementation Lowers Clinic Blood Pressure in Untreated Primary Hypertension-Systematic Review and Meta-Analysis of Randomized Trials.
This systematic review and meta-analysis assessed oral potassium supplementation versus placebo, sodium chloride, or no treatment in adults with untreated primary hypertension.
Endpoint-specific mortality associated with malignancy among adults with sepsis or septic shock: a systematic review and meta-analysis.
This systematic review and meta-analysis examined mortality among adults with sepsis or septic shock, comparing patients with and without malignancy.
Application of Electrical Impedance Tomography-Guided Pulmonary Rehabilitation Strategy in Patients with Respiratory Failure.
This randomized controlled trial evaluated an electrical impedance tomography (EIT)-guided pulmonary rehabilitation strategy in 92 ICU patients with respiratory failure at a tertiary hospital; 88 completed the study.
Prone positioning and high-frequency oscillatory ventilation in early paediatric acute respiratory distress syndrome (PROSpect): an international, two-by-two factorial, response-adaptive, phase 3, randomised controlled trial.
PROSpect was an international, two-by-two factorial, phase 3 randomised controlled trial comparing prone with supine positioning and high-frequency oscillatory ventilation (HFOV) with conventional mechanical ventilation…
Between Skin and Brain: A Systematic Review of 712 Cases 1976-2025 Reveals a Highly Diverse Disease Spectrum in Chaetothyriales.
This systematic review examined the global epidemiology, causative species, clinical presentations, and outcomes of 712 reported Chaetothyriales infections from 1976 to 2025.
Virtual Social Interaction and Psychological Capital in Chemotherapy Patients: A Randomized Controlled Trial.
This single-blind randomized controlled trial evaluated a six-week virtual social interaction program for 76 patients receiving chemotherapy at one Iranian hospital.
Decitabine plus busulfan-cyclophosphamide versus busulfan-cyclophosphamide myeloablative conditioning before allogeneic haematopoietic stem cell transplantation for reducing risk of relapse in adult KMT2A‑rearranged leukaemia in China: an open-label, multicentre, randomised phase 3 trial.
This open-label, multicentre, randomised phase 3 trial compared decitabine plus busulfan-cyclophosphamide (DAC-BuCy) with BuCy conditioning before allogeneic HSCT in 130 patients aged 14–65 years with KMT2A-rearranged…
Acute declines in kidney function with thiazide plus loop diuretics versus loop diuretics alone in acute decompensated heart failure.
This analysis of the randomized CLOROTIC trial examined whether early eGFR changes were associated with outcomes in patients admitted with acute decompensated heart failure and randomized to thiazide or placebo…
Heterogeneity in Depression and Suicidality Risk Among Vitiligo Patients: A Meta-Analysis of Adolescent Complexity and Subgroup Stratification.
This meta-analysis assessed depression and suicidality in people with vitiligo, drawing on 73 studies identified through searches of four databases. The pooled prevalence of depression was 0.37 (95% CI, 0.30-0.45).
Metabolic, hormonal, and reproductive effects of GLP-1 receptor agonizts in hyperandrogenic insulin-resistant women: a systematic review.
This systematic review evaluated GLP-1 receptor agonists for metabolic, hormonal, and reproductive outcomes in adult women with hyperandrogenic insulin-resistant conditions, principally polycystic ovary syndrome and…
Artificial Intelligence-Enabled Electrocardiogram Screening for Detection of Low Ejection Fraction in Routine Care: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated randomised controlled trials of AI-enabled ECG screening for low ejection fraction in adults without known heart failure undergoing routine ECGs.
Effectiveness of Tomazoni Measurement Method for Central Catheter Tip Positioning in Neonates: A Randomised Controlled Trial.
This pragmatic, parallel-group randomised controlled trial compared the Tomazoni and traditional measurement methods for positioning peripherally inserted central catheter (PICC) tips in neonates at a Brazilian neonatal…
Sexual dimorphism and age effects in CKD and type 2 diabetes in the CONFIDENCE trial.
This analysis of the randomized CONFIDENCE trial examined age- and sex-related differences in urinary albumin-to-creatinine ratio (UACR) changes among people with type 2 diabetes and chronic kidney disease receiving…
Prevalence of depression and anxiety among patients with Behçet's disease: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis estimated depression and anxiety prevalence among patients with Behçet’s disease (BD).
A Systematic Review and Meta-Analysis of Randomized Clinical Trials Comparing the Effectiveness of Corticosteroid Injection Versus Night Splints in Patients With Carpal Tunnel Syndrome.
This systematic review and meta-analysis of randomized controlled trials compared corticosteroid injection (CSI) with night splinting (NS) for carpal tunnel syndrome.
Ectopic cushing syndrome caused by intestinal neuroendocrine tumors: a systematic review.
This systematic review characterized ectopic Cushing syndrome caused by intestinal neuroendocrine tumors using published case reports and an illustrative unpublished case. It identified 24 published cases.
Chlorhexidine within a standardized oral-care bundle for the prevention of ventilator-associated pneumonia: a pragmatic cluster-randomized crossover trial in six medical intensive care units.
This pragmatic cluster-randomized crossover trial in six adult medical ICUs at one Indian tertiary-care hospital compared a standardized oral-care bundle with the same bundle plus 0.12% chlorhexidine (CHX) in adults…
BCMA-directed CAR T-cell therapy induces durable drug-free remission in refractory primary immune thrombocytopenia.
This phase I clinical trial evaluated B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell therapy in 4 patients with refractory primary immune thrombocytopenia.
Performance of 0/1 h versus 0/3 h pathways in patients with suspected myocardial infarction: a systematic review and individual participant data meta-analysis of randomised controlled trials.
This systematic review and individual participant data meta-analysis combined five randomised trials comparing 0/1 h with 0/3 h cardiac troponin pathways in patients presenting with suspected myocardial infarction.
Human milk oligosaccharide (2'-FL) modifies the gut microbiome in children after bone marrow transplant.
This prospective phase 1/2 clinical trial evaluated daily oral 2′-fucosyllactose (2′-FL), a human milk oligosaccharide, from conditioning through day +30 in children undergoing allogeneic hematopoietic stem cell…
Levodopa or dopamine agonists for enhancing motor function after stroke.
This Cochrane systematic review and meta-analysis assessed whether levodopa or dopamine agonists improve motor function after stroke.
Maternity versus non-maternity healthcare settings for the diagnosis of gestational diabetes or diabetes in pregnancy.
This Cochrane systematic review and meta-analysis assessed whether maternity or non-maternity healthcare settings affect screening and diagnosis of gestational diabetes or diabetes in pregnancy.
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