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2000 articles
November 202624
The Safety, Pharmacokinetics, and Antiviral Activity of ABI-4334, A Novel Next-Generation Hepatitis B Capsid Assembly Modulator.
Two randomized Phase 1 studies assessed ABI-4334, a hepatitis B capsid assembly modulator, in healthy volunteers and participants with chronic hepatitis B (cHBV).
Effect of dietary counselling on educational disparities in cardiometabolic health from childhood to adulthood.
This randomized controlled study examined whether parental education was associated with cardiometabolic health from childhood to adulthood and whether it modified the effects of dietary counselling.
Alfred Kocher technique for prevention of patient-prosthesis mismatch in paediatric patients.
A 7-year-old girl requiring aortic valve replacement had a functionally unicuspid aortic valve. Although the Ross procedure is generally favored in children, an intraoperative bicuspid pulmonary valve made durable…
Acute Ethylene Glycol Poisoning Following Accidental Mineral Oil Ingestion With Severe Metabolic Acidosis, Acute Kidney Injury, Respiratory Failure, and Delayed Neurological Sequelae: A Case Report.
A 57-year-old man became dizzy, vomited, and developed altered consciousness progressing to coma after accidentally ingesting mineral oil containing ethylene glycol.
The Effect of Shoulder Support on Shoulder Subluxation in Stroke Survivors Based on Ultrasonography Findings: A Randomized Clinical Trial.
This single-blind randomized controlled trial assessed whether adding a standardized shoulder support to conventional rehabilitation improved shoulder subluxation, pain, upper-limb motor function, or independence in 40…
Effects of Morning Strength and Power Priming Exercises on Afternoon Physical and Cognitive Performance in Male Rugby Union Players.
This randomised, counterbalanced study examined whether morning strength and power exercises affected afternoon physical and cognitive performance in 25 male rugby union players.
Is Exercise Effective at Reducing Pain Catastrophizing in People With Chronic Nonspecific Spinal Pain? A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined whether exercise reduces pain catastrophizing in people with chronic nonspecific spinal pain.
Regimens of vitamin D supplementation for women during pregnancy.
This updated Cochrane systematic review and meta-analysis assessed randomised trials of vitamin D regimens during pregnancy in women without pre-existing conditions or multiple pregnancies.
XR serious games for phantom limb pain, neurofunctional recovery, and prosthetic adoption: a systematic review.
This systematic review synthesized studies of extended-reality serious games for adults with limb amputation, examining phantom limb pain, rehabilitation, embodiment, and prosthesis adoption.
Clinical Reasoning: A 55-Year-Old Woman With a Hyperkinetic Movement Disorder, External Ophthalmoplegia, and Myopathy.
A 55-year-old woman was evaluated for an 8-year history of hyperkinetic movements. Her examination and clinical picture also included mild ataxia, spasticity in the lower limbs, external ophthalmoplegia, and myopathy.
Poly (ADP-ribose) polymerase inhibitors (PARPi) for treating advanced epithelial ovarian cancer.
This Cochrane systematic review and meta-analysis assessed randomised trials of PARP inhibitors (PARPi) in women with newly diagnosed or recurrent epithelial ovarian cancer. It included 24 studies with 8961 participants.
Primary Synovial Sarcoma of the Thyroid Gland Presenting With Early Pulmonary Metastasis: Diagnostic Pathway, SS18 Gene Fusion Confirmation, and Clinical Course.
A 47-year-old woman presented with dysphagia and a left-sided neck mass. Initial fine-needle aspiration was non-diagnostic; repeat sampling suggested a spindle cell neoplasm.
ID-SCAN: a functional MRI protocol for neurophenomenological phenotyping of dissociative identity disorder without trauma provocation.
A woman with dissociative identity disorder and persistent co-consciousness between two identity-agents completed ID-SCAN, a functional MRI protocol that did not use trauma provocation.
Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.
This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…
Physical Activity in Young Girls With Functional Abdominal Pain Disorders: Findings of a Randomized Controlled Intervention Trial With Dance and Yoga.
This randomized controlled trial assessed daily physical activity and abdominal pain in girls aged 9 to 13 years with functional abdominal pain disorders who participated in an 8-month dance and yoga intervention.
Conservative versus surgical management of traumatic acute subdural hematoma: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis compared surgical with conservative management of traumatic acute subdural hematoma in adults.
Cutaneous Silent Period-Based Comparison of Dorsal Root Ganglion Pulsed Radiofrequency and Transforaminal Epidural Steroid Injection in Lumbar Radicular Pain: A Randomized Controlled Trial.
This prospective, single-blind randomized controlled trial compared dorsal root ganglion pulsed radiofrequency (DRG-PRF) with transforaminal epidural steroid injection (TFESI) in 36 patients with chronic unilateral…
Postoperative Tumor-Informed Circulating Tumor DNA Status for Molecular Residual Disease Detection After Curative-Intent Resection of Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled observational evidence on postoperative tumor-informed circulating tumor DNA (ctDNA) as a marker of molecular residual disease after curative-intent resection of…
Intimate partner violence against women in Ethiopia: An umbrella review of systematic reviews and meta-analyses.
This umbrella review and random-effects meta-analysis synthesized six systematic reviews and meta-analyses, covering 80 primary studies and 43,785 women in Ethiopia, to estimate intimate partner violence (IPV)…
Efficacy and safety of selective orexin 2 receptor agonists in narcolepsy type 1: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis pooled randomized, double-blind, placebo-controlled trials of oral selective orexin 2 receptor agonists in people with narcolepsy type 1.
Polyamine Dysregulation in Metabolic Dysfunction-associated Steatotic Liver Disease: a Systematic Review of Human Observational Evidence.
This systematic review evaluated human observational evidence linking polyamines with MASLD severity and related hepatic or metabolic outcomes.
Efficacy and safety of middle meningeal artery embolisation for chronic subdural haematoma: a systematic review and meta-analysis of randomised controlled trials.
This PRISMA-compliant systematic review and meta-analysis pooled randomised controlled trials comparing middle meningeal artery embolisation (MMAE)-based treatment with standard management in adults with radiologically…
Digital Health Interventions for Pregnancy- and Childbirth-Related Posttraumatic Stress Disorder Symptoms in Postpartum Women: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled randomized controlled trials of digital health interventions for postpartum women who had experienced pregnancy- or childbirth-related trauma.
Perioperative neurocognitive outcomes after robot-assisted pelvic surgery: a systematic review and meta-analysis of reported proportions, comparative risk and prognostic factors.
This systematic review and meta-analysis examined delirium and cognitive decline after robot-assisted pelvic surgery in adults, including reported proportions, comparative risk, and prognostic factors.
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