Trending archive
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1303 articles
November 202624
Effects of the integrated care on healthcare utilization and costs among patients with diabetes and depression: a cluster-randomized controlled trial.
This cluster-randomized controlled trial in community health centers in China assessed whether Community-based Integrated Care for Patients with Diabetes and Depression affected healthcare use and costs.
What works for whom? A systematic mapping review of psychological treatments for adults with longstanding anorexia nervosa.
This systematic mapping review examined quantitative interventional studies of psychological treatments for adults with longstanding anorexia nervosa (AN), searching four databases for studies published between 2005 and…
Barriers to Gender-Affirming Care for Nonbinary People: A Systematic-Narrative Hybrid Literature Review.
This systematic-narrative hybrid literature review synthesised qualitative, quantitative and mixed-methods research, alongside systematic and scoping reviews, on barriers to gender-affirming care for nonbinary people.
Catatonic signs during delirium in leptomeningeal melanoma: Treatment trade-offs in end-of-life care.
A man in his late 30s with metastatic melanoma involving the leptomeninges and brain developed fluctuating arousal, inattention, disorientation, mutism, immobility, staring, withdrawal, and waxy flexibility.
Children of advanced cancer patients need better support: A case report.
This case study describes a parent with advanced cancer and minor children who needed support in discussing the diagnosis, preparing the children for the possibility of death, and addressing anticipatory grief.
Efficacy of Lumateperone 42 mg in Major Depressive Disorder: Subgroup Analysis of a Phase 3 Randomized, Placebo-Controlled Trial.
This post hoc subgroup analysis of a phase 3, randomized, double-blind, placebo-controlled trial assessed adjunctive lumateperone 42 mg in adults with major depressive disorder and inadequate response to antidepressant…
Effect of Blonanserin on Neurotrophic Factors in Patients With Non-Responsive First-Episode Schizophrenia Treated With Early Risperidone Monotherapy-A Randomized Controlled Trial.
This randomized controlled trial compared blonanserin with clozapine over 3 months in 120 hospitalized patients with first-episode schizophrenia who had not responded to early risperidone monotherapy.
Persistent Amotivation After Cannabis-Related Psychosis: Diagnostic Challenges and Clinical Course With Electroconvulsive Therapy: A Case Report.
A 19-year-old man developed auditory hallucinations, persecutory delusions, and agitation associated with cannabis use. Antipsychotic treatment improved the psychosis, but marked amotivation and inactivity persisted…
Pharmacological treatment of bereavement-related distress: a systematic review.
This systematic review assessed pharmacological treatments for bereavement-related psychological distress, including depression following bereavement.
Caring Contacts and Suicidality Among American Indian and Alaska Native Communities: A Randomized Clinical Trial.
The CARE study was a blinded, two-group randomized clinical trial of 709 American Indian and Alaska Native adults with active suicidality across five communities.
Severe neuropsychiatric manifestations in a 17-year-old male with a 20p13 interstitial deletion encompassing CSNK2A1: a case report.
A 17-year-old male had a de novo interstitial 419 kb deletion at 20p13 encompassing CSNK2A1. His presentation was considered compatible with Okur-Chung neurodevelopmental syndrome, although the deletion was described as…
Effects of bystander interventions on school bullying: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed school-based bystander interventions for bullying and cyberbullying among children and adolescents, drawing on 23 experimental and quasi-experimental controlled studies.
RELAX Perinatal Digital Intervention to Prevent Increasing Anxiety: A Randomized Clinical Trial.
This multisite, phase 2b randomized clinical trial tested whether a self-led, pregnancy-tailored digital cognitive bias modification intervention added to usual maternity care could prevent rising anxiety in pregnant…
Generative Artificial Intelligence and Maternal Health Outcomes in Pregnant and Postpartum Individuals: A Randomized Clinical Trial.
This 2-group randomized clinical trial assessed whether a generative AI maternal health chatbot improved outcomes among 400 pregnant or postpartum participants from racial and ethnic minoritized groups recruited across…
A Scalable Teacher Professional Development and Wellness Program in Primary Schools: A Cluster Randomized Clinical Trial.
This cluster randomized clinical trial evaluated professional development (PD), with or without a teacher-wellness enhancement (PDT), in 47 urban and rural primary schools in Uganda.
Effectiveness of Traditional Chinese Fitness Methods on Depressive Symptoms and Glycaemic Control in Patients With Type 2 Diabetes and Comorbid Depression: A Systematic Review and Meta-Analysis of Taijiquan and Baduanjin.
This systematic review and meta-analysis assessed randomised controlled trials of Taijiquan and Baduanjin in people with type 2 diabetes and comorbid depression. Eight trials, all conducted in China, were included.
Association of Caregiver Mental Health and a Childhood Parenting Intervention in China.
This clustered randomized controlled trial tested whether caregiver mental health modified the effects of a center-based parenting intervention in 100 rural Chinese villages.
Therapeutic Horseback Riding for Youth With Autism and Psychiatric Comorbidities: A Randomized Trial.
This multisite randomized controlled trial evaluated equine-assisted activities in youth aged 6–16 years with autism and psychiatric comorbidity.
The Cognitive Functions of Youth With Obesity: A Meta-Analysis.
This PRISMA-guided meta-analysis pooled 22 studies comparing youth under 18 with obesity and normal-weight peers, using random-effects models to assess seven cognitive domains.
Plasma Lipidomic Features of Adolescent Major Depressive Disorder and Lipid Changes After Fluoxetine Treatment.
This clinical trial study used UHPLC-MS/MS to compare plasma lipid profiles in 75 adolescents with major depressive disorder (MDD) and 75 matched healthy controls, and to assess changes after fluoxetine in 44…
Telehealth Treatment of Anxiety in Patients With Low-Risk Chest Pain in the Emergency Department: The PACER Randomized Clinical Trial.
The PACER multicentre, three-group randomised comparative effectiveness trial tested peer-supported internet-based cognitive behavioural therapy (iCBT) and therapist-delivered telehealth CBT against primary care…
Efficacy of Technology-Augmented Behavioral Counseling for Risky Firearm Behaviors: A Randomized Clinical Trial.
This two-arm randomized clinical trial tested IntERact, a 30-day program combining telehealth behavioral counseling and tailored smartphone content, against enhanced usual care among 373 emergency department patients…
Clinical Trajectory of Late-Onset Delusional Disorder Toward Evolving Dementia With Lewy Bodies.
The report revisited four clinicopathological cases in which late-onset delusional disorder was the initial manifestation of Lewy body disease.
Structural Brain Correlates of Bulimia Nervosa Diagnosis and Symptom Severity: A Coordinated ENIGMA Eating Disorders Working Group Analysis.
This coordinated, international case-control meta-analysis examined structural MRI correlates of bulimia nervosa (BN) diagnosis and symptom severity across 17 cohorts at 13 sites.
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