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557 articles
November 20268
Eltrombopag during induction chemotherapy in older patients with newly diagnosed acute myeloid leukemia is safe and reduces platelet transfusion requirements: The EPAG-2015 French Innovative Leukemia Organization phase 2 randomized trial.
The multicentre, phase 2 randomized trial EPAG-2015 evaluated eltrombopag started after induction chemotherapy in patients aged 60 years or older with newly diagnosed acute myeloid leukemia.
Paraneoplastic Autoimmune Multiorgan Syndrome: Diagnostic Lessons for Pediatricians.
An 11-year-old boy developed subacute erythroblastopenia, followed by polymorphic mucocutaneous findings, severe myositis with a dermatomyositis-like phenotype, and mild hepatitis.
Phase 2 Trial of 89 Zr-Deferoxamine-Daratumumab for CD38-targeted Immuno-PET/CT Detection of Multiple Myeloma.
This prospective phase 2 trial compared CD38-targeted 89Zr-DFO-daratumumab immuno-PET/CT with standard-of-care 18F-FDG PET/CT in 60 participants with multiple myeloma.
Genotypic-Phenotypic Correlations in Non-HbE β-Thalassemia Intermedia: A Geographic Systematic Review.
This PRISMA-guided systematic review qualitatively synthesized 21 studies of genotype–phenotype correlations in non-HbE β-thalassemia intermedia, a heterogeneous disorder now included within non-transfusion-dependent…
A Triad of Hematologic Diseases in a Military Member Requiring Splenectomy Case Report.
An active-duty servicemember with hereditary spherocytosis, sickle cell trait, and Factor VII deficiency developed recurrent, worsening pain crises after flights.
Therapeutic Approaches and Clinical Outcomes of Myeloid/Lymphoid Neoplasms With Eosinophilia Harboring FLT3 Rearrangements: A Systematic Review of 39 Cases.
This systematic review examined treatment approaches and outcomes in 39 reported cases of myeloid/lymphoid neoplasms with eosinophilia harboring FLT3 rearrangements, a rare malignancy without standardized treatment…
Preemptive Kidney Transplantation in a Pediatric Patient With Factor XI Deficiency: A Case Report.
A 14-year-old boy with end-stage renal disease from congenital posterior urethral valves underwent preemptive living-donor heterotopic kidney transplantation from his brother.
Polyneuropathy, Organomegaly, Endocrinopathy, M-Protein, and Skin Changes (POEMS) Syndrome With Characteristic Muscle Biopsy Findings and Without M-Protein.
A 63-year-old woman referred with presumed CIDP had not responded to IVIG or steroids. Her presentation included marked weight loss, papilledema, skin changes, thrombocytosis, thromboembolisms, hemi-diaphragmatic…
October 202616
Decitabine plus busulfan-cyclophosphamide versus busulfan-cyclophosphamide myeloablative conditioning before allogeneic haematopoietic stem cell transplantation for reducing risk of relapse in adult KMT2A‑rearranged leukaemia in China: an open-label, multicentre, randomised phase 3 trial.
This open-label, multicentre, randomised phase 3 trial compared decitabine plus busulfan-cyclophosphamide (DAC-BuCy) with BuCy conditioning before allogeneic HSCT in 130 patients aged 14–65 years with KMT2A-rearranged…
Conservative management of disseminated intravascular coagulation caused by uterine leiomyoma degeneration in pregnancy: Case report and review.
A 35-year-old woman at 25 weeks’ gestation presented with lower abdominal pain and a tender 6.5 cm uterine leiomyoma; fetal well-being and placental appearance were normal on ultrasonography.
Haemodialysis in haemophilia B: a case report. Challenges and strategies from a nephrology perspective.
A 68-year-old man with severe haemophilia B and kidney failure required kidney replacement therapy. He received prophylactic Idelvion® (albutrepenonacog alfa), then underwent arteriovenous fistula creation and started…
Unmasking Panic Disorder in Adults with Leukemia: A Systematic Review of Prevalence, Risk Factors, and Management.
This PRISMA-guided systematic review examined panic disorder and anxiety in adults with leukemia, searching four databases for studies published from 2015 to July 20, 2025.
Human milk oligosaccharide (2'-FL) modifies the gut microbiome in children after bone marrow transplant.
This prospective phase 1/2 clinical trial evaluated daily oral 2′-fucosyllactose (2′-FL), a human milk oligosaccharide, from conditioning through day +30 in children undergoing allogeneic hematopoietic stem cell…
Tagraxofusp, azacitidine, and venetoclax for blastic plasmacytoid dendritic cell neoplasm.
This phase 2 clinical trial evaluated tagraxofusp, azacitidine, and venetoclax in 27 patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN): 16 previously untreated and 11 with relapsed or refractory…
BCMA-directed CAR T-cell therapy induces durable drug-free remission in refractory primary immune thrombocytopenia.
This phase I clinical trial evaluated B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell therapy in 4 patients with refractory primary immune thrombocytopenia.
Peritoneal Tuberculosis and Chronic Myeloid Leukaemia: A Case of Hickam's Dictum.
A 34-year-old man presented with persistent fever, ascites, thrombocytosis and clinical deterioration despite broad-spectrum therapy.
BILATERAL PARACENTRAL ACUTE MIDDLE MACULOPATHY IN A PEDIATRIC PATIENT WITH SICKLE CELL DISEASE.
An 8-year-old boy with HbSS sickle cell disease and no previous sickle cell retinopathy developed blurred vision, headache, photopsia, and metamorphopsia during an influenza A-associated upper respiratory illness.
Treatment of Crimean-Congo Hemorrhagic Fever With Supportive Care, Favipiravir, and Avatrombopag.
A patient with severe Crimean-Congo hemorrhagic fever was managed in a high-level isolation unit with supportive care, favipiravir, and avatrombopag.
Treatment of Progressive Multifocal Leukoencephalopathy With Third-Party Allogeneic BK Virus T Cells.
This single-center phase 2 study evaluated third-party, partially HLA-matched BK virus-specific T cells in 37 patients with progressive multifocal leukoencephalopathy (PML), including 23 with hematologic malignancy.
Post-transplant BRAF/MEK inhibitor maintenance sustains complete remission in BRAF V600E-mutant histiocytic sarcoma.
A patient with refractory BRAF V600E-mutant histiocytic sarcoma achieved complete remission with BRAF/MEK inhibition and then underwent allogeneic stem cell transplantation.
Zamtocabtagene autoleucel, a tandem CD20-CD19-directed CAR T-cell therapy, for second line treatment of large B-cell lymphoma in patients ineligible for transplantation (DALY 2-EU): primary analysis of an open-label, multicentre, randomised phase 2 study.
DALY 2-EU was an open-label, multicentre, randomised phase 2 trial comparing tandem CD20-CD19-directed zamtocabtagene autoleucel (zamto-cel) with R-GemOx in adults with second-line relapsed or refractory large B-cell…
Efficacy and Safety of Apixaban Thromboprophylaxis According to Baseline Chemotherapy Class in High-Risk Ambulatory Cancer Patients: A Post Hoc Analysis of the AVERT Trial.
This post hoc analysis of the randomized, double-blind AVERT trial examined apixaban thromboprophylaxis by baseline chemotherapy class in 563 ambulatory patients with cancer starting chemotherapy.
Ravulizumab monotherapy for anti-CFH antibody-associated aHUS in an elderly patient: a case report highlighting individualized clinical decision-making.
An 85-year-old man presented with acute kidney injury, thrombocytopenia, microangiopathic hemolytic anemia, and severe hypertension.
The role of tyrosine kinase inhibitors as a post-hematopoietic stem cell transplant continuation therapy for pediatric acute leukemia: a systematic review.
This systematic review assessed tyrosine kinase inhibitors (TKIs) as continuation therapy after hematopoietic stem cell transplantation (HSCT) in children with acute leukemia.
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