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2000 articles
November 202624
Multikinase Inhibition with Tinengotinib in Advanced Solid Tumors: Results from a Multicenter Phase Ib/II Trial.
This multicenter phase Ib/II trial evaluated tinengotinib’s safety, pharmacokinetics, antitumor activity, and genomic correlates in patients with advanced or metastatic solid tumors lacking standard treatment options.
Effects of Dual-Task Training With and Without Backward Walking on Balance, Functional Mobility, and Participation in Ambulatory Children With Spastic Diplegic Cerebral Palsy: A Randomized Controlled Trial.
This randomized controlled trial compared dual-task training (DTT) with DTT incorporating backward walking (BW) in 44 ambulatory children aged 6–12 years with spastic diplegic cerebral palsy (GMFCS I–II).
Pearls & Oy-sters: The Price of Patency: Intractable Headache Subsequent to Fourth Ventricular Recanalization.
A 61-year-old woman with secondary fourth ventricular hemorrhage was treated using an IRRAflow active irrigation and drainage system.
An Exploratory Study of Image-Guided Cochlear Implant Intervention on Articulation and Phonological Processing in Children With Speech Sound Disorders.
This exploratory analysis examined articulation and phonological processing in 21 children aged 4.7–13.1 years with cochlear implants and deficits in these skills, enrolled in a 2-year waitlist-deferred randomized…
Extended Follow-up of Botensilimab plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer without Active Liver Metastases.
This phase Ib clinical trial evaluated botensilimab plus balstilimab in patients with previously treated microsatellite-stable metastatic colorectal cancer without active liver metastases.
Selective Electrical Muscle Stimulation of the Vastus Medialis in a Patient With Knee Osteoarthritis, With Changes in Muscle Quality, Symptoms, and Physical Activity: A Case Report.
A 77-year-old man with Kellgren-Lawrence grade 2 right knee osteoarthritis had stopped regular exercise, including aquatic walking, because of knee pain.
Clinical effectiveness and safety of bacterial cellulose dressings in the management of skin wounds: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed the efficacy and safety of bacterial cellulose dressings compared with conventional treatments for skin wounds.
Comparison of the opioid-sparing effects of a combination of dexamethasone, paracetamol, and ketorolac versus paracetamol and ketorolac in patients undergoing total laparoscopic hysterectomy: A prospective double-blind randomized controlled trial.
This prospective, double-blind randomized controlled trial compared adding intravenous dexamethasone to paracetamol and ketorolac with paracetamol and ketorolac alone in 100 women aged 18–60 years with ASA I–II status…
Effects of Vitamin D 3 Supplementation on Glycaemic Parameters and Insulin Sensitivity in Pre-diabetic Adults: A Prospective Controlled Interventional Study.
This prospective controlled interventional study assessed daily oral vitamin D3 alongside lifestyle advice in 90 pre-diabetic adults aged 18–65 years in Chennai, compared with lifestyle advice alone.
Neoadjuvant concurrent or sequential anthracycline-containing chemotherapy and HER2-targeted agents for HER2-positive breast cancer: a randomized phase 2 study (METIS).
The randomized phase II METIS trial compared neoadjuvant pegylated liposomal doxorubicin (PLD)-based chemotherapy given concurrently with trastuzumab and pertuzumab against sequential epirubicin/cyclophosphamide-based…
Prognostic value of Murray law-based quantitative flow ratio after percutaneous coronary intervention.
This prespecified subgroup analysis of the randomised FAVOR III China trial assessed whether post-PCI Murray law-based quantitative flow ratio (μQFR) was associated with long-term outcomes.
Adjunctive neodymium-doped yttrium aluminum garnet laser therapy for periodontitis in type 2 diabetes: A randomized controlled trial.
This randomized controlled trial compared conventional nonsurgical periodontal therapy with or without adjunctive neodymium-doped yttrium aluminum garnet laser therapy in 120 patients with periodontitis and type 2…
Short-term bioavailability of EPA and DHA from an algae oil-fortified soymilk compared with algae oil capsules.
This 4-week, open-label, randomized parallel trial compared short-term EPA and DHA bioavailability from algae oil-fortified soymilk with algae oil capsules in 21 healthy adults.
Randomized Single-Masked Study of Preservative-Free Versus Preserved Hyaluronic Acid in Dry Eye Disease.
This randomized, single-masked, 6-month trial compared preservative-free hyaluronic acid (PF HA) with benzalkonium chloride-preserved hyaluronic acid (BAK HA) in 47 patients with dry eye disease; 43 completed the study.
Tirzepatide-associated severe euvolemic hyponatremia with syndrome of inappropriate antidiuretic hormone secretion-compatible biochemical features.
A woman with type 2 diabetes and morbid obesity, taking regular insulin and chronic torsemide, developed anorexia, weakness, and drowsiness 10 days after receiving tirzepatide.
Visual Perceptual Learning Based on Adaptive Contrast Detection Training Enhances Vision and Contrast Sensitivity in Diabetic Retinopathy.
This randomized controlled trial evaluated 3-month home-based visual perceptual learning (VPL) in people with diabetic retinopathy who had received routine therapies.
Changes in Alcohol Use among Adults with Cancer Participating in the ECOG-ACRIN EAQ171CD Tobacco Treatment Trial.
This post hoc analysis of the randomized ECOG-ACRIN EAQ171CD tobacco-treatment trial examined alcohol-risk changes among 305 adults with cancer who smoked, comparing virtual sustained treatment (VST) with enhanced usual…
Ethnoracial and Linguistic Diversity in Treatment Research for Primary Progressive Aphasia: A Systematic Review.
This systematic review examined ethnoracial, linguistic, and social-determinant representation in nonpharmacological intervention research for people with primary progressive aphasia (PPA) or primary progressive apraxia…
Effect of Blonanserin on Neurotrophic Factors in Patients With Non-Responsive First-Episode Schizophrenia Treated With Early Risperidone Monotherapy-A Randomized Controlled Trial.
This randomized controlled trial compared blonanserin with clozapine over 3 months in 120 hospitalized patients with first-episode schizophrenia who had not responded to early risperidone monotherapy.
Effects of bystander interventions on school bullying: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed school-based bystander interventions for bullying and cyberbullying among children and adolescents, drawing on 23 experimental and quasi-experimental controlled studies.
Phase 1/2 trial of Evomela for autologous transplant in myeloma: schedule optimization and matched comparison with MEL200.
This prospective, randomized phase 1/2 trial evaluated Evomela dose and infusion schedule in 60 patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation.
Effects of extremely low-volume high-intensity interval training combined with iron supplementation versus iron supplementation alone on postural control in young women with iron deficiency anemia: a randomized controlled trial.
This randomized controlled trial compared 8 weeks of extremely low-volume, plyometric-based high-intensity interval training (HIIT) plus oral iron with iron supplementation alone in young women aged 18–25 years with…
Dapagliflozin attenuates progression from prefrailty to frailty in patients with hypertension and chronic kidney disease.
DAPA-FORTRESS followed prefrail hypertensive adults aged over 65 years with chronic kidney disease (CKD) for 1 year to examine links between renal measures and physical performance, and whether dapagliflozin was…
Tuberculous meningoencephalitis in a heart transplant recipient: a case report.
A 33-year-old heart transplant recipient receiving immunosuppression developed headache, fever, and focal neurological signs after a complicated admission that included an incidental miliary pulmonary pattern on chest…
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