Trending archive
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557 articles
June 20269
Alpha-2 antiplasmin deficiency: a rare fibrinolytic disorder identified after decades of diagnostic delay.
A woman presented with decades of postoperative bleeding and transfusion dependence, initially misdiagnosed with von Willebrand disease.
Multimodal Management of Anti-GBM Disease Complicated by Secondary Complement-Mediated Thrombotic Microangiopathy in a Patient Intolerant to Plasma Exchange: A Case Report.
A 46-year-old woman with anti-GBM disease developed thrombotic microangiopathy, with preserved ADAMTS13 activity (72.04%) and 2.3% schistocytes.
Longitudinal Neurocognitive Changes for Patients With Hematologic Malignancies Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review With Structured Narrative Synthesis.
This systematic review evaluated longitudinal neurocognitive changes in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT).
Is tattooing associated with an increased risk of cancer? A systematic review and meta-analysis.
This systematic review and meta-analysis assessed whether tattoo exposure was associated with skin cancer or hematological malignancies in adults, pooling seven observational studies with 140,841 participants.
Suspected thermal amplitude of cryoglobulin likely more clinically significant than size detected: A case report.
A patient with known lymphoplasmacytic lymphoma developed extensive necrosis of the fingers and toes. Testing detected a small type I cryoglobulin, but its significance was uncertain.
Management of anticoagulation in patients with heparin-induced thrombocytopenia requiring cardiac surgery with cardiopulmonary bypass: guidance from the ISTH SSC on Perioperative and Critical Care Haemostasis and Thrombosis.
This systematic review evaluated anticoagulation strategies for patients with heparin-induced thrombocytopenia (HIT) undergoing cardiac surgery with cardiopulmonary bypass.
Evaluation of ex-utero collection for umbilical cord blood banking: A randomized clinical trial comparing cord blood quality with the in-utero technique.
This prospective, unblinded randomized clinical trial compared ex-utero with standard in-utero umbilical cord blood collection among pregnant women at a Barcelona hospital and cord blood program.
Orbital involvement in sickle cell disease: A systematic review.
This systematic review analyzed 76 cases of orbital involvement in sickle cell disease (SCD) from 53 studies. Predominantly affecting males with an average age of 13.2 years, the review highlighted that 6.6% presented…
Acquired ring chromosomes in hematological malignancies: A systematic evidence review for diagnostic advances, cytogenomic insights, and clinical significance by an International Consortium on Human Ring Chromosomes (ICHRC) working group.
This systematic review by the International Consortium on Human Ring Chromosomes (ICHRC) examines acquired ring chromosomes (aRCs) in hematological malignancies.
May 202615
Maintenance treatment and survival in patients with newly diagnosed diffuse large B cell lymphoma in the immunochemotherapy era: a systematic review and network meta-analysis.
This systematic review and network meta-analysis compared maintenance strategies after initial treatment in previously untreated patients with diffuse large B-cell lymphoma (DLBCL), using randomized trials.
Diffuse Large B-Cell Lymphoma Presenting as a Thigh Mass: A Case Report.
A 76-year-old female presented with swelling and pain in her right thigh. Imaging revealed a soft-tissue mass that raised concerns for sarcoma.
Pegcetacoplan Delivers Real-World Therapeutic Benefits and Reduces Disease Burden for Patients With Paroxysmal Nocturnal Haemoglobinuria: A Systematic Literature Review of Pegcetacoplan Real-World Clinical and Patient-Reported Outcomes.
This systematic literature review evaluated real-world evidence for pegcetacoplan in adults with paroxysmal nocturnal haemoglobinuria (PNH).
Rare and complex three-way t(8;11;21) translocation in core-binding factor acute myeloid leukemia transforming into refractory mediastinal myeloid sarcoma: cytogenetic and molecular insights.
A young patient with core-binding factor acute myeloid leukemia (CBF-AML) and the RUNX1::RUNX1T1 fusion gene presented with a rare three-way t(8;11;21) translocation, alongside mutations in KIT, ASXL1, and TET2.
Disseminated MRSA and Myelokathexis Preceding AML with t(8;21) and ASXL1 Mutation.
A 13-year-old boy presented with two months of fever, pancytopenia, and disseminated MRSA abscesses. Bone marrow showed myelokathexis without blasts; evaluation did not support WHIM syndrome or another inborn error of…
A case of congenital thrombotic thrombocytopenic purpura presenting with renal dysfunction in adulthood caused by a novel compound heterozygous ADAMTS13 mutation.
A 36-year-old male presented with acute thrombocytopenia and a 5-year history of chronic thrombocytopenia, alongside 3 months of renal dysfunction.
Thrombotic microangiopathy-like acute kidney injury revealing a germline GATA1 mutation in a child with inherited cytopenia.
An 8-year-old boy with a history of steroid-dependent cytopenias and congenital anomalies presented with severe infection, hemolysis, thrombocytopenia, and acute kidney injury requiring hemodialysis.
Oral manifestation and gingival biopsy contributing to the early diagnosis of Langerhans cell histiocytosis in a paediatric patient.
A 3-year-old child presented with bilateral osteolytic lesions, significant bone loss, and multiple ulcerative gingival lesions. Accompanying symptoms included lymphadenopathy and cranial pain.
Atypical short tandem repeat allelic patterns in a sexual assault case involving hematopoietic stem cell transplantation.
A female victim of sexual assault underwent forensic examination, revealing conflicting short tandem repeat (STR) profiles in various biological samples.
RCLARITY: A Prospective Phase II Study of Rituximab Combined With Lenalidomide and Chidamide (RLC) for the Treatment of Relapsed/Refractory Angioimmunoblastic T-Cell Lymphoma.
The RCLARITY trial, a prospective Phase II study, evaluated the efficacy and safety of a chemotherapy-free regimen combining rituximab, lenalidomide, and chidamide in 28 adults with relapsed/refractory…
Secondary leukaemia after testicular germ cell tumour treatment: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the incidence of secondary leukaemia in 57,365 patients treated for testicular germ cell tumours (TGCTs).
Life-threatening hemorrhage from acquired factor V deficiency with non-inhibitory, hyperclearance-type antibodies successfully treated with rituximab then belimumab.
A 66-year-old woman with Sjögren’s disease and no previous bleeding tendency presented with rapidly worsening low back pain and severe coagulopathy.
Primary Oral MALT Lymphoma Without Nodal or Systemic Involvement: A Rare Presentation.
A middle-aged patient presented with a slow-growing, asymptomatic oral lesion that was initially misidentified as an oral lipoma.
Performance of Automated Hematology Analyzer Criteria in Detecting Peripheral Blood Smear Abnormalities: A Systematic Literature Review.
This systematic review analyzed 68 studies over 20 years to evaluate the performance of automated hematology analyzers in detecting peripheral blood smear (PBS) abnormalities.
Dual pathogenic variants in ADAMTS13 and CFHR1/CFHR3 deletion: divergent thrombotic microangiopathy phenotypes in siblings.
Two male siblings presented with hereditary anemia and thrombocytopenia, along with unexplained hepatosplenomegaly. The elder sibling developed acute thrombotic microangiopathy (TMA) with severe complications, while the…
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