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2000 articles
November 202624
Metaplastic Carcinoma of the Breast: A Rare Biphasic Tumour-case Report and Literature Review.
A 49-year-old woman presented with a chronic right breast lump that enlarged rapidly over 3 months, with weight loss and fever. Examination found a large, firm mass and ipsilateral axillary lymphadenopathy.
A Phase I First-Time-in-Human, Open-label Study of Nelistotug Administered to Patients with Advanced Solid Tumors.
This first-in-human, open-label, nonrandomized, multicenter phase I study evaluated nelistotug, an anti-CD96 antibody, alone or with dostarlimab, and in a three-drug combination with dostarlimab and belrestotug in…
Pharmacological treatment of bereavement-related distress: a systematic review.
This systematic review assessed pharmacological treatments for bereavement-related psychological distress, including depression following bereavement.
Danvatirsen plus Pembrolizumab versus Pembrolizumab for Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma (PEMDA-HN): A Randomized, Phase II Trial.
PEMDA-HN was a multicenter, open-label, randomized phase II trial comparing first-line danvatirsen plus pembrolizumab with pembrolizumab alone in patients with previously untreated, PD-L1-positive recurrent or…
Acceptability of a patient support and educational intervention for black breast cancer survivors.
This clinical trial evaluated the feasibility and acceptability of a six-week group support and education intervention for English-speaking Black women who had survived stage I–III breast cancer diagnosed within the…
Optimizing the Therapeutic Index: Sequential Intraarterial-Intravenous PRRT with Personalized Volumetric-Adjusted Dosing.
This prospective clinical trial assessed a personalized sequence of intraarterial then intravenous 177Lu-DOTATATE in 10 adults with progressive, nonresectable, liver-dominant metastatic gastroenteropancreatic…
Clinical Reasoning: An 18-Year-Old Woman With Episodic Stiffness, Exercise Intolerance, and Weakness: Decoding a Neuromuscular Mystery.
An 18-year-old woman had longstanding episodic muscle stiffness, cold sensitivity, exercise intolerance, and stable proximal weakness.
Wernicke's encephalopathy secondary to hyperemesis gravidarum in pregnancy.
A 28-year-old woman at 17 weeks’ gestation presented with severe hyperemesis gravidarum and cerebellar dysfunction. She met three of the four European Federation of Neurological Societies diagnostic requirements for…
Leptomeningeal carcinomatosis arising from esophageal cancer: a systematic review of the literature.
This systematic review synthesized 31 studies describing 43 patients with leptomeningeal carcinomatosis arising from esophageal cancer.
Associations of Health Literacy and eHealth Literacy With Patient Portal Access and Use: Systematic Review.
This systematic review synthesized quantitative studies of health literacy and eHealth literacy in relation to real-world patient portal access and use among adults.
Expanding the role of ivabradine in thyrotoxic crisis: a case report and Insights from the Literature.
A 39-year-old woman with alemtuzumab-induced Graves’ disease developed thyroid storm with persistent sinus tachycardia despite high-dose propranolol.
An Approach to Acute Cranial Symptoms in Primary Care: Lesson From a Case of Miller Fisher Syndrome.
A 38-year-old woman developed acute diplopia, right eye pain, headache, and perioral numbness two weeks after an upper respiratory infection.
Neoadjuvant Nivolumab plus Carboplatin and Paclitaxel in Patients with Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck: A Phase II, Single-Arm Trial.
This single-arm, open-label phase II trial evaluated neoadjuvant nivolumab plus carboplatin and paclitaxel in patients with newly diagnosed, locally advanced, resectable head and neck squamous cell carcinoma, including…
Severe neuropsychiatric manifestations in a 17-year-old male with a 20p13 interstitial deletion encompassing CSNK2A1: a case report.
A 17-year-old male had a de novo interstitial 419 kb deletion at 20p13 encompassing CSNK2A1. His presentation was considered compatible with Okur-Chung neurodevelopmental syndrome, although the deletion was described as…
Fucoidan as an anti-inflammatory and immunomodulatory agent in humans: a systematic review of clinical evidence and translational potential.
This systematic review assessed human interventional studies of fucoidan supplementation for inflammatory, immune, metabolic, and tumour-related outcomes.
The risk of rhegmatogenous retinal detachment associated with topical pilocarpine: a systematic review.
This systematic review assessed whether topical pilocarpine is associated with rhegmatogenous retinal detachment (RRD) in patients aged 40 years or older, synthesising 10 comparative studies.
Drug-drug interactions between statins and antibiotics: A systematic review and meta-analysis of observational studies.
This systematic review and meta-analysis assessed observational evidence on muscle toxicity when statins are used with interacting antibiotics, compared with statin therapy alone.
Germline Genetic Variants and Epilepsy Surgery Response: Individual Participant Pooled Analysis of 272 Patients.
This systematic review and individual-participant pooled analysis examined seizure outcomes after resection or laser ablation in 272 people with pathogenic or likely pathogenic germline epilepsy variants, excluding…
Full-Service Mobile Food Markets and Dietary Quality in Low-Income Housing Communities: A Randomized Clinical Trial.
This cluster randomized clinical trial evaluated weekly full-service mobile market service at 12 subsidized housing sites in the Minneapolis–St. Paul area.
A Phase II Trial of Pembrolizumab plus Granulocyte-Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer.
This single-center phase II trial evaluated pembrolizumab plus GM-CSF in 42 patients with advanced biliary cancers previously treated with chemotherapy and without prior immune checkpoint inhibitor therapy.
Autologous Blood Pleurodesis for Postoperative Air Leakage Following Video-Assisted Thoracoscopic Surgery-A Randomized Controlled Trial.
This multicentre randomised controlled trial assessed early autologous blood pleurodesis (ABP) for postoperative air leakage after elective video-assisted thoracoscopic surgery.
Early Metformin Initiation and Glycemic Outcomes in Gestational Diabetes: A Secondary Analysis of a Randomized Clinical Trial.
This secondary analysis of a double-masked, placebo-controlled randomized clinical trial assessed early metformin versus placebo, alongside usual care, in pregnancies complicated by gestational diabetes at two Irish…
Role of magnesium as a protective agent in cisplatin-induced nephrotoxicity in head and neck cancer.
This randomized controlled trial evaluated intravenous magnesium sulfate for prevention of cisplatin-induced nephrotoxicity in 100 newly diagnosed patients with head and neck squamous cell carcinoma receiving concurrent…
EMB-01, an Anti-EGFR/c-MET Bispecific Antibody, in Patients with Heavily Pretreated Metastatic Colorectal Cancer from a Phase Ib/II, Open-Label, Multicenter Study.
This phase Ib/II, open-label, multicenter study evaluated weekly intravenous EMB-01, an EGFR/c-MET bispecific antibody, in patients predominantly with heavily pretreated metastatic colorectal cancer (mCRC).
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