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1382 articles
September 202624
Electro-clinical efficacy and safety of midazolam in neonatal seizures: a systematic review with individual level exploratory analysis of gestational age-related treatment response.
This systematic review evaluated the electro-clinical efficacy and safety of midazolam in treating neonatal seizures, involving 146 neonates.
Clinical heterogeneity and disease progression during adolescence in AGPAT2-associated congenital generalized lipodystrophy: a case series of four patients.
This case series followed four adolescents with genetically confirmed AGPAT2-associated congenital generalized lipodystrophy.
Deep brain stimulation outcomes in pediatric drug-resistant epilepsy: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the long-term efficacy and safety of deep brain stimulation (DBS) in 149 pediatric patients with drug-resistant epilepsy (DRE).
Efficacy and neural mechanisms of transcranial direct current stimulation for social function in children and adolescents with autism spectrum disorder: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed transcranial direct current stimulation (tDCS) for social functioning and neurophysiological outcomes in children and adolescents with autism spectrum disorder.
Effect of Intraoperative Hemispheric Synchronized Sounds on Depth of Anesthesia and Postoperative Pain in Children Undergoing Infraumbilical Surgery: A Double-Blinded Randomized Controlled Trial.
This double-blinded randomized controlled trial compared intraoperative hemispheric synchronized sounds with a blank audio file in 60 children aged 6 months to 7 years undergoing elective infraumbilical surgery with…
Intraosseous venous malformation of the clivus.
A teenage female presented with a 1-month history of intermittent right-sided tongue numbness and twitching. Investigations, including laboratory tests and an electroencephalogram, were unremarkable.
Pediatric hepatic sarcoidosis presenting as hypersplenism and portal hypertension.
A mid-childhood female presented with massive splenomegaly, pancytopenia, and portal hypertension, but without constitutional or respiratory symptoms.
Smartphone Apps for Preventing Adolescent Health Problems Among Health Care Professionals: Systematic Search and Quality Assessment.
This systematic review evaluated smartphone apps aimed at helping healthcare professionals identify at-risk adolescents across various preventive health areas.
Oral amoxicillin for management of fast breathing or chest indrawing pneumonia without danger signs in children aged 2-59 months: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of oral amoxicillin in children aged 2-59 months with fast breathing pneumonia and chest indrawing pneumonia without danger signs.
Spontaneous complete regression of congenital brain tumors - a systematic literature review and case report.
A 3-month-old infant presented with a posterior fossa tumor that underwent spontaneous complete regression. The case highlights the variability in clinical presentation and tumor characteristics among congenital brain…
Neonatal unilateral testicular torsion in the first 16 hours of life: A case report and literature review.
A 16-hour-old male neonate was admitted for hyperbilirubinemia but was found to have unilateral scrotal swelling during examination.
Immunogenicity of fractional one-fifth and one-half doses of 17DD yellow fever vaccine compared with full dose in children aged 9-23 months in Uganda: a phase 4, single-blind, randomised clinical trial.
This phase 4, single-blind, randomised trial compared one-fifth (0·1 mL) and one-half (0·25 mL) with full (0·5 mL) doses of 17DD yellow fever vaccine in children aged 9–23 months at three Ugandan public-sector…
Novel SLC6A9 variants in an adult presenting with GlyT1 encephalopathy.
A 27-year-old man with GlyT1 encephalopathy was found to carry two novel compound-heterozygous SLC6A9 variants. His features included neonatal hypotonia followed by hypertonicity, respiratory failure, exaggerated…
Disparities in treatment initiation following diagnosis of attention-deficit/hyperactivity disorder: a systematic review.
This systematic review examined whether sociodemographic factors are associated with time to treatment initiation after ADHD diagnosis in children and adolescents.
USP6-FISH Negative Nodular Fasciitis: Benign Impostor of the Orbit.
An 11-year-old boy had a painless, progressively enlarging periorbital mass initially thought to be a dermoid cyst. Ultrasound was reassuring, but MRI showed an enhancing lesion concerning for neoplasm, leading to…
Effect of Thermal Softening of Endotracheal Tubes on Perioperative Respiratory Adverse Events in Children Undergoing Adenotonsillectomy: A Randomized Controlled Trial.
This prospective randomized controlled trial assessed whether warming endotracheal tubes (ETTs) to 37°C reduces perioperative respiratory adverse events (PRAEs) in 254 children aged 3–9 years undergoing elective…
Immunogenicity and safety of inactivated TZ84- vs. HM175-based hepatitis A vaccines in pediatric populations: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the immunogenicity and safety of TZ84- vs. HM175-based hepatitis A vaccines in children and adolescents.
Iodine supplementation for preventing iodine deficiency disorders in children and adolescents.
This systematic review and meta-analysis evaluated the effects of iodine supplementation on preventing iodine deficiency disorders in children and adolescents, including 2528 participants across eight randomized…
Effectiveness of a digi-physical tool and working method for paediatric obesity treatment in Abu Dhabi: a non-inferiority intervention study using an external historical comparator.
This non-inferiority intervention study evaluated the effectiveness of a digi-physical tool for treating pediatric obesity in 60 children aged 6-15.9 years in Abu Dhabi.
Preserving beta cell function in children and adolescents with newly diagnosed stage 3 type 1 diabetes: per-protocol population analysis from the PROTECT randomised trial.
This pre-specified per-protocol analysis of the multicentre, randomised PROTECT trial assessed teplizumab in children and adolescents aged 8–17 years with newly diagnosed stage 3 type 1 diabetes.
Blinatumomab-induced catastrophic immune effector cell-associated neurotoxicity with diffuse cerebral edema in a patient with ALL: Case report.
A 13-year-old boy with MLL-AF4-positive precursor B-ALL developed catastrophic neurotoxicity during blinatumomab therapy. After initially tolerating treatment, he experienced fever on day 13 of the second cycle, leading…
A Multimethod Evaluation to Assess Feasibility, Acceptability, and Preliminary Efficacy of HPVVaxFacts, a Tailored Mobile Web App, for Parents With Unvaccinated Children: Pilot 2-Arm Randomized Controlled Trial.
This pilot randomized controlled trial evaluated the feasibility, acceptability, and preliminary efficacy of HPVVaxFacts, a mobile web app designed for parents of unvaccinated adolescents aged 9-17.
Recurrent C19MC-altered embryonal tumors with multilayered rosettes: outcomes of stereotactic radiosurgery.
This report discusses three pediatric patients with recurrent embryonal tumors with multilayered rosettes (ETMR) who were treated with stereotactic radiosurgery (SRS) after initial gross total resection and adjuvant…
Effect of a perioperative digital serious game (PeroPap) on pain and anxiety in children: A randomized controlled trial.
This randomized controlled trial evaluated the PeroPap digital serious game for its effectiveness in reducing pain and anxiety in 182 children aged 7-10 undergoing surgery.
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