Recurrent C19MC-altered embryonal tumors with multilayered rosettes: outcomes of stereotactic radiosurgery.
Paul M Harary, Yusuke S Hori, Sze Kiat Tan et al.
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Case in brief
This report discusses three pediatric patients with recurrent embryonal tumors with multilayered rosettes (ETMR) who were treated with stereotactic radiosurgery (SRS) after initial gross total resection and adjuvant therapy. One patient remains stable 22 months post-diagnosis, another achieved local control but later developed leptomeningeal spread, and the third has been disease-free for 16 years. SRS was well-tolerated in all cases.
Diagnostic / clinical pearl
Stereotactic radiosurgery may be an effective salvage treatment for localized recurrence of ETMR, potentially extending survival while minimizing neurocognitive risks associated with traditional radiotherapy.
Why it matters
This case highlights the need for further research to clarify the role of SRS within multimodal treatment protocols for aggressive pediatric brain tumors.