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2000 articles
November 202624
Radiomics performance to identify high-risk carotid artery plaques: a systematic review.
This systematic review assessed radiomics-based models for identifying high-risk carotid plaques. It included 28 studies involving 6,108 patients, 72.4% of whom were male.
KARS1-Related Infantile-Onset Progressive Leukoencephalopathy With or Without Deafness: A Novel Variant and Phenotypic Expansion.
A two-year-old Iranian boy born to non-consanguineous parents presented with developmental delay, seizures, and sensorineural hearing loss.
A phase Ia first-in-human study of BPB-101, a novel trifunctional antibody targeting the GARP/TGF-β complex and PD-L1, in patients with locally advanced or metastatic solid tumors.
This phase Ia, multicenter, first-in-human dose-escalation study evaluated BPB-101, a trifunctional antibody targeting the GARP/TGF-β complex and PD-L1, in previously treated patients with advanced or metastatic solid…
Coronary artery calcification is not associated with survival in advanced gastric and gastroesophageal junction cancer: a secondary analysis of the EXPAND trial.
This secondary analysis of baseline CT images from the phase III EXPAND trial assessed whether coronary artery calcification (CAC) predicted overall survival in 785 patients with unresectable locally advanced or…
Catatonic signs during delirium in leptomeningeal melanoma: Treatment trade-offs in end-of-life care.
A man in his late 30s with metastatic melanoma involving the leptomeninges and brain developed fluctuating arousal, inattention, disorientation, mutism, immobility, staring, withdrawal, and waxy flexibility.
Submucosal Tunnel Endoscopic Resection of a Gastric Schwannoma Mimicking a Submucosal Tumor.
A 73-year-old woman with recurrent abdominal distension was found on esophagogastroduodenoscopy to have an 8.2 mm submucosal lesion in the gastric body.
Efficacy of Lumateperone 42 mg in Major Depressive Disorder: Subgroup Analysis of a Phase 3 Randomized, Placebo-Controlled Trial.
This post hoc subgroup analysis of a phase 3, randomized, double-blind, placebo-controlled trial assessed adjunctive lumateperone 42 mg in adults with major depressive disorder and inadequate response to antidepressant…
Variation in recommendations for management of pediatric fever and neutropenia across databases and languages: A systematic review of clinical practice guidelines.
This systematic review and content analysis examined evidence-based clinical practice guidelines (CPGs) for fever and neutropenia in children, assessing how database indexing and publication language affected guideline…
Immunothrombosis Biomarkers and Multi-Omics Profiles After Successful Recanalization in Patients Receiving Ischemic Postconditioning: An Exploratory Analysis of the INSPIRE Trial.
This exploratory secondary analysis of the randomized INSPIRE trial examined 60 patients with ischemic stroke after successful endovascular thrombectomy recanalization.
Tetracaine hydrochloride gel delays and reduces catheter-related bladder discomfort after transurethral resection: a randomized controlled trial.
This randomized, single-blind trial compared tetracaine hydrochloride gel with standard lubricant in 130 patients undergoing transurethral resection.
Primary Endocrine Therapy vs Upfront Surgery for Older Women With Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared primary endocrine therapy (pET) with upfront surgery for operable, nonmetastatic, estrogen receptor-positive breast cancer in older women.
Generative Artificial Intelligence and Maternal Health Outcomes in Pregnant and Postpartum Individuals: A Randomized Clinical Trial.
This 2-group randomized clinical trial assessed whether a generative AI maternal health chatbot improved outcomes among 400 pregnant or postpartum participants from racial and ethnic minoritized groups recruited across…
A Comparative Study of the Efficacy and Safety of Two Misoprostol Regimens for Labour Induction at Term in Delta State: A Two-centre Triple-blind Randomised Controlled Trial.
This two-centre, triple-blind randomised controlled trial compared hourly titrated oral misoprostol with four-hourly 25 mcg vaginal misoprostol for labour induction in 260 singleton term pregnancies in Delta State…
Proton-pump inhibitor-induced severe hypomagnesemia presenting with seizure and functional hypoparathyroidism: A diagnostic challenge in long-term acid suppression therapy.
A 68-year-old man taking omeprazole 40 mg/day for 8 years presented with a generalized tonic-clonic seizure and neuromuscular irritability.
Safety, Biodistribution, and Dosimetry of FAP and Integrin α v β 3 Dual-Targeting Radioligand 177 Lu-DOTA-FAPI-RGD: Preclinical Validation and First-in-Human Study in Patients with Advanced Adenocarcinomas.
This phase I, first-in-human study evaluated the safety, biodistribution, dosimetry, and preliminary efficacy of the dual-targeting radioligand 177Lu-LNC1009 in nine patients with advanced solid tumors and positive…
Comparison of Traumatic Complications following Prostate Biopsy in Men with Lower Urinary Tract Symptoms Due to Prostate Disease Using Biopty Gun versus Semiautomatic Needle.
This randomised comparative study assessed pain and bleeding after digitally guided transrectal prostate biopsy using a semiautomatic needle or a fully automatic biopty gun in 64 men with lower urinary tract symptoms…
Safety and Efficacy of Intratumoral MEDI1191, an IL12 mRNA Lipid Nanoparticle, plus Intravenous Durvalumab in Patients with Advanced Solid Tumors: A First-in-Human Study.
This open-label, multicenter, first-in-human phase I dose-escalation study evaluated intratumoral MEDI1191, an IL-12 mRNA lipid nanoparticle, with intravenous durvalumab in adults with advanced or metastatic solid…
Orthoplastic Limb Salvage Using Transtibial Transport and Free-Flap Reconstruction in Patients With Diabetes-Related Chronic Limb-Threatening Ischemia.
A 56-year-old man with poorly controlled diabetes and severe peripheral arterial disease developed a chronic foot ulcer with toe gangrene despite unsuccessful revascularization, leaving no conventional revascularization…
Low-level laser therapy in ulcerative lesions in leprosy: a systematic review.
This systematic review assessed whether low-level laser therapy (LLLT) improves healing of ulcerative lesions in people with leprosy.
RELAX Perinatal Digital Intervention to Prevent Increasing Anxiety: A Randomized Clinical Trial.
This multisite, phase 2b randomized clinical trial tested whether a self-led, pregnancy-tailored digital cognitive bias modification intervention added to usual maternity care could prevent rising anxiety in pregnant…
Breast Adenomyoepithelioma with Malignant Changes in a 36-year-old Female: Clinicopathological, Histomorphological and Therapeutic Considerations.
A woman described in the abstract as 360 years old presented with an asymptomatic left breast tumour measuring 2.5 cm × 2.0 cm × 0.8 cm.
Sphenoidal Meningioma with Focal Seizures Masquerading as Immune Reconstitution Inflammatory Syndrome in HIV Patient.
A 47-year-old woman with HIV developed recurrent focal-onset seizures progressing to bilateral tonic-clonic seizures about 4 weeks after starting antiretroviral therapy.
A Scalable Teacher Professional Development and Wellness Program in Primary Schools: A Cluster Randomized Clinical Trial.
This cluster randomized clinical trial evaluated professional development (PD), with or without a teacher-wellness enhancement (PDT), in 47 urban and rural primary schools in Uganda.
Dual Inhibition of LAG-3 and PD-1 with IBI110 and Sintilimab in Advanced Alveolar Soft Part Sarcoma: A Single-Center, Phase II Trial.
This open-label, single-center phase II trial evaluated IBI110 plus sintilimab in 28 patients with advanced alveolar soft part sarcoma (ASPS), including patients who were naïve or resistant to prior immune checkpoint…
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