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1357 articles

November 202624

Clinical ResearchOrthopedic Surgery

The Effect of Virtual Reality on Anxiety and Vital Signs in Patients Undergoing Total Knee Replacement Surgery: A Randomized Controlled Trial.

This randomized controlled trial evaluated whether intraoperative virtual reality affected anxiety and vital signs in 70 patients undergoing total knee replacement.

Comput Inform NursNov 1, 2026Read summary
Clinical ResearchPediatrics

Immunogenicity and Safety of PHH-1V COVID-19 Vaccine as a Heterologous Booster in Adolescents.

This phase IIb, open-label, multicenter noninferiority trial evaluated PHH-1V as a heterologous COVID-19 booster in healthy adolescents aged 12 to under 18 years previously primed with BNT162b2.

PediatricsNov 1, 2026Read summary
Clinical ResearchPediatricsOpen access

The Cognitive Functions of Youth With Obesity: A Meta-Analysis.

This PRISMA-guided meta-analysis pooled 22 studies comparing youth under 18 with obesity and normal-weight peers, using random-effects models to assess seven cognitive domains.

Brain BehavNov 1, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Intravenous lidocaine does not provide additional pain reduction beyond placebo in probable nociplastic chronic low back pain: a randomized controlled equivalence trial.

This randomized, placebo-controlled equivalence trial assessed repeated intravenous lidocaine in 84 adults with chronic non-specific low back pain and probable nociplastic pain features.

Pain MedNov 1, 2026Read summary
Clinical ResearchNephrologyOpen access

Transplantation of Hepatitis B Surface Antigen Positive or Viremic Kidneys: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed outcomes after transplantation of hepatitis B surface antigen-positive or viremic kidneys into non-viremic kidney transplant recipients.

Clin TransplantNov 1, 2026Read summary
Clinical ResearchRadiology (Diagnostic)

Artificial Intelligence for Assessing the Relationship Between Mandibular Third Molars and the Inferior Alveolar Nerve on Panoramic Radiographs: A Systematic Review.

This systematic review assessed artificial intelligence (AI) models that use panoramic radiographs to evaluate the relationship between mandibular third molars and the inferior alveolar nerve, with cone-beam computed…

Med Oral Patol Oral Cir BucalNov 1, 2026Read summary
Clinical ResearchPsychiatryOpen access

Plasma Lipidomic Features of Adolescent Major Depressive Disorder and Lipid Changes After Fluoxetine Treatment.

This clinical trial study used UHPLC-MS/MS to compare plasma lipid profiles in 75 adolescents with major depressive disorder (MDD) and 75 matched healthy controls, and to assess changes after fluoxetine in 44…

CNS Neurosci TherNov 1, 2026Read summary
Clinical ResearchEndocrinology

Adults With Type 1 Diabetes Are Less Physically Active Than Adults Without Diabetes: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis compared physical activity and sedentary behaviour in adults with type 1 diabetes and adults without diabetes.

Diabetes Metab Res RevNov 1, 2026Read summary
Clinical ResearchGastroenterologyOpen access

Effect of Food on the Pharmacokinetics, Pharmacodynamics, and Safety of Zastaprazan, a Potassium-Competitive Acid Blocker, in Healthy Participants.

This randomized, open-label, two-period crossover phase 1 study assessed food effects on zastaprazan pharmacokinetics, pharmacodynamics, and safety in 24 healthy participants given a single 20 mg dose.

Clin Transl SciNov 1, 2026Read summary
Clinical ResearchNeurology

The Impact of Outcome Measures for Responder Analyses in Placebo-Controlled Trials of Pharmacological Treatments for Neuropathic Pain.

This meta-analysis examined how dichotomous responder definitions affect estimated treatment effects in placebo-controlled pharmacological trials for neuropathic pain.

Eur J PainNov 1, 2026Read summary
Clinical ResearchPediatrics

Effects of Physical Activity Interventions on Body Composition in Korean Students With Intellectual Disabilities: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed physical activity interventions and body composition in students with intellectual disabilities in Korea.

J Appl Res Intellect DisabilNov 1, 2026Read summary
Clinical ResearchCardiology

Home Blood Pressure-Guided Lifestyle Intervention for Elevated Blood Pressure Detected at Workplace Health Checkups: A Randomized Pilot Trial.

This randomized pilot trial evaluated home blood pressure (BP) monitoring as part of lifestyle management for elevated BP detected at workplace health checkups.

J Clin Hypertens (Greenwich)Nov 1, 2026Read summary
Clinical ResearchPediatrics

Implementing Respiratory Illness Care Pathways in General Hospitals: A Cluster Randomized Trial.

This pragmatic, multicenter cluster-randomized trial evaluated implementation of inpatient pathways for asthma, pneumonia, and bronchiolitis in US general hospitals.

PediatricsNov 1, 2026Read summary
Clinical ResearchRheumatology

Prevalence of Sleep Disorders in Patients With Knee, Hip, and Hand Osteoarthritis: A Systematic Review With Meta-Analysis.

This prevalence systematic review and meta-analysis assessed insomnia, obstructive sleep apnea, restless legs syndrome, and narcolepsy in people with knee, hip, or hand osteoarthritis.

J Orthop Sports Phys TherNov 1, 2026Read summary
Clinical ResearchOphthalmologyOpen access

Dexamethasone Eye Drops to Prevent Treatment-Requiring Retinopathy of Prematurity: The DROPROP Randomized Clinical Trial.

The DROPROP double-masked, multicentre randomised clinical trial tested whether topical dexamethasone could prevent progression to treatment-requiring type 1 retinopathy of prematurity (ROP) in preterm infants born…

JAMA PediatrNov 1, 2026Read summary
Clinical ResearchObstetrics & GynecologyOpen access

Assessing the reproductive lifespan of female cancer survivors using AMH: a meta-synthesis of longitudinal studies.

This systematic review and meta-synthesis quantified AMH changes after cancer treatment in female survivors and compared longer-term trajectories with age-matched controls.

Hum Reprod UpdateNov 1, 2026Read summary
Clinical ResearchPathology (Anatomic & Clinical)

Salivary biomarkers in periodontal diseases: A systematic review.

This systematic review assessed salivary biomarkers for diagnosing and monitoring periodontitis in systemically healthy people. It included 11 human studies with cross-sectional or interventional designs.

J Am Dent AssocNov 1, 2026Read summary
Clinical ResearchNephrologyOpen access

Effects of a Nurse-Led Multicomponent Exercise Intervention for Haemodialysis Patients With Possible or Confirmed Sarcopenia: A Cluster Randomised Trial.

This cluster randomised trial evaluated a 12-week nurse-led multicomponent exercise programme in haemodialysis patients with possible or confirmed sarcopenia.

Nurs OpenNov 1, 2026Read summary
Clinical ResearchOphthalmology

In-the-Bag Stability of a New Hydrophilic Acrylic Toric Intraocular Lens.

This single-centre, prospective interventional clinical trial assessed in-the-bag stability of the RayOne EMV toric intraocular lens in 119 eyes of 79 patients with age-related cataract over 6 months.

J Refract SurgNov 1, 2026Read summary
Clinical ResearchOrthopedic Surgery

Supervised physiotherapeutic scoliosis-specific exercises provide limited additional benefit at 24 months in braced adolescents with idiopathic scoliosis: a randomized trial.

This randomized trial compared supervised Schroth-based physiotherapeutic scoliosis-specific exercises (PSSE) with self-directed general exercise in adolescents with idiopathic scoliosis receiving brace treatment.

Bone Joint JNov 1, 2026Read summary
Clinical ResearchEmergency MedicineOpen access

Pain-Related Outcome Domains and Measures in Randomized Controlled Trials of Treatment for Acute Abdominal Pain: A Systematic Review.

This PRISMA-guided systematic review mapped pain-related outcome domains and measures in randomized controlled trials of acute abdominal pain treatment.

Eur J PainNov 1, 2026Read summary
Clinical ResearchDermatology

INDIVIDUAL ARTICLE: Randomized Double-Blind, Placebo-Controlled Study of a Supplement and Serum on Grey Hair.

This randomized, double-blind, placebo-controlled study assessed a topical serum and oral supplement, alone and in combination, in 173 men and women aged 28–65 years with 5–25% grey hair.

J Drugs DermatolNov 1, 2026Read summary
Clinical ResearchGastroenterology

Clinical significance of isolated periappendiceal red patch in ulcerative colitis: A systematic review, meta-analysis, and meta-regression.

This systematic review and meta-analysis examined whether an isolated periappendiceal red patch (PARP) is associated with disease extent or outcomes in ulcerative colitis.

Inflamm Bowel DisNov 1, 2026Read summary
Clinical ResearchCardiology

Impact of Aspirin Use on Mortality and Cardiac Allograft Vasculopathy After Heart Transplantation: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis examined whether aspirin use was associated with mortality and cardiac allograft vasculopathy (CAV)-related outcomes in heart transplant recipients.

Clin TransplantNov 1, 2026Read summary

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