INDIVIDUAL ARTICLE: Randomized Double-Blind, Placebo-Controlled Study of a Supplement and Serum on Grey Hair.
Vinay Bhardwaj, Nancy Rodgers, Cristiane D Oliveira et al.
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In 30 seconds
This randomized, double-blind, placebo-controlled study assessed a topical serum and oral supplement, alone and in combination, in 173 men and women aged 28–65 years with 5–25% grey hair. Participants were assigned to one of four groups: combination, supplement alone, serum alone, or placebo. The combination group had a 9.2% reduction in grey hairs at week 12 and a 13.0% reduction at week 24, compared with a 9.7% increase in the placebo group by week 24. The between-group difference at week 24 was significant (P=0.004).
Key findings
- Combination treatment was associated with a 9.2% reduction in grey hairs at week 12 (P=0.034 vs baseline) and a 13.0% reduction at week 24 (P=0.016 vs baseline).
- The placebo group had a 9.7% increase in mean grey-hair count from baseline to week 24; the week-24 comparison with combination treatment was significant (P=0.004).
- Photo grading and participant observation also showed reductions in grey hair with combination treatment (P=0.002 for each assessment vs baseline at week 24).
Why it matters
The trial reports a measurable reduction in grey-hair counts with a combined topical and oral regimen, addressing an outcome for which the abstract notes that clinical-trial evidence of repigmentation or slowed greying has been lacking. The findings may inform further evaluation of this approach, while the reported results apply to the tested products and study population.
What to keep in mind
The abstract reports outcomes for the combination group but does not provide results for the supplement-only and serum-only groups, limiting assessment of each component's contribution.