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557 articles
July 202621
Phase III Study of Niraparib Plus Pembrolizumab as Maintenance Therapy for Advanced or Metastatic NSCLC (ZEAL-1L).
ZEAL-1L was a randomized, double-blind, multicentre phase III trial of maintenance niraparib plus pembrolizumab versus placebo plus pembrolizumab in adults with advanced or metastatic squamous or nonsquamous NSCLC…
Unusual aspect of cuticular morphology in human pulmonary dirofilariasis.
A 79-year-old woman presented with a slowly enlarging pulmonary nodule in the right upper lobe, leading to a partial lung resection.
Assessing time to symptomatic progression, a patient-relevant efficacy endpoint, in the MARIPOSA study in non-small cell lung cancer.
The phase 3 MARIPOSA study evaluated the efficacy of amivantamab and lazertinib versus osimertinib in patients with untreated, EGFR-mutated advanced non-small cell lung cancer.
Qibai Pingfei Capsule ameliorates NK‑cell dysfunction in COPD: Insights from single‑cell sequencing in a randomized multicenter double‑blinded placebo‑controlled trial.
This randomized, double-blind, placebo-controlled, multicenter trial investigated the effects of Qibai Pingfei Capsule (QBPF) on chronic obstructive pulmonary disease (COPD) patients.
Post Hoc Analysis of Solriamfetol Efficacy in Obstructive Sleep Apnea Patients with Excessive Daytime Sleepiness Stratified by Disease Severity.
This post hoc analysis of a randomized controlled trial evaluated solriamfetol's efficacy in Chinese patients with obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS), stratified by disease severity.
Microbial Etiology of Empyema Thoracis in Children: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined the microbial etiology of empyema in children, analyzing 36 studies. It found that Staphylococcus aureus was the most prevalent organism in pleural fluid (38.99%) and…
Exploring the mechanism of Zhichuanling oral liquid in treating childhood bronchial asthma based on network pharmacology and experimental verification.
This randomized controlled study assessed Zhichuanling Oral Liquid (ZCL) added to conventional treatment in 60 children with bronchial asthma, alongside network pharmacology and mouse and cell experiments.
Pleural Fluid Cytology Detects Small Cell Carcinoma Transformation in EGFR-Mutant Lung Adenocarcinoma: A Case Report.
A 65-year-old woman with EGFR-mutant lung adenocarcinoma experienced a massive pleural effusion after initially responding to icotinib.
Ifebemtinib plus garsorasib as first-line treatment for KRAS G12C -mutated non-small-cell lung cancer in China: a multicentre, single-arm expansion cohort from a phase 1b/2 trial.
This multicentre, single-arm phase 2 trial evaluated the efficacy and safety of ifebemtinib plus garsorasib in 33 treatment-naive patients with KRAS G12C-mutated non-small-cell lung cancer (NSCLC) in China.
A rapid turn for the worse: Steroid-responsive pulmonary haemorrhage in leptospirosis.
A 43-year-old man presented with fever and cough, initially treated for community-acquired pneumonia. He rapidly deteriorated, developing type 1 respiratory failure.
Predictors of Recurrence Following Bronchial Artery Embolisation (BAE) for Haemoptysis: A Systematic Review and Evidence Synthesis Analyses Using SWiM Guidelines.
This systematic review synthesised cohort studies of haemoptysis recurrence after bronchial artery embolisation (BAE), using a Synthesis Without Meta-analysis approach because of clinical heterogeneity and mixed embolic…
Impact of biologic therapy on ICS/LABA adherence in severe asthma: assessment of inhaler therapy adherence remains imperative.
This prospective, single-centre randomised-trial sub-study assessed electronically recorded ICS/LABA use and inhalation technique over six months in 14 patients with severe asthma starting biologic therapy.
Number Needed to Treat with Biologics in Type-2 Inflammation COPD: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the number needed to treat (NNT) for type-2-targeted biologics in adults with moderate-to-severe COPD.
Eight-week high-intensity inspiratory muscle training improves cardiac autonomic function in COPD: a randomized controlled trial.
This randomized controlled trial investigated the effects of eight weeks of high-intensity inspiratory muscle training on cardiac autonomic function in 39 stable COPD patients.
Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild-to-moderate asthma.
Two open-label, single-dose Phase 1 studies assessed tezepelumab pharmacokinetics, pharmacodynamics and safety in adolescents aged 12–17 years with mild-to-moderate asthma and children aged 5–11 years with mild…
High-Flow Nasal Oxygen in Early Home Pulmonary Rehabilitation for Exertional Hypoxaemia: A Pilot Randomised Feasibility Trial.
This pilot randomized feasibility trial evaluated the integration of high-flow nasal oxygen (HFO) in an early home-based pulmonary rehabilitation (PR) program for patients with exertional hypoxaemia (EH)…
Outcomes of conservative management of CT-diagnosed hemothorax in chest trauma: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed conservative management of CT-diagnosed traumatic hemothorax in stable patients.
Underrepresentation of Rural Populations in Tele-Pulmonary Rehabilitation Trials: A Systematic Review.
This systematic review assessed whether people with chronic obstructive pulmonary disease from rural communities were represented in tele-pulmonary rehabilitation (tele-PR) randomised controlled trials.
Remimazolam Versus Midazolam for Sedation in Mechanically Ventilated Patients with Severe Pneumonia: A Randomized Controlled Trial.
This single-center, prospective randomized controlled trial compared remimazolam with midazolam for sedation in 68 adults with severe pneumonia receiving invasive mechanical ventilation.
When Size Matters: Advanced Treatment of Acute Pulmonary Embolism Caused by a Large Snake-Like Thrombus.
A 56-year-old female patient presented with pulmonary embolism-related obstructive shock complicated by cardiac arrest. Computed tomography revealed a large snake-like thrombus.
Effects of integrated inspiratory-expiratory muscle training within hybrid cardiac rehabilitation following cardiac surgery: A randomized controlled study.
This randomized controlled trial evaluated the impact of adding respiratory muscle training (RMT) to hybrid cardiac rehabilitation (HCR) in 20 patients post-cardiac surgery.
June 20263
The risk of primary lung cancer in ANCA-associated vasculitis: systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the risk of lung cancer in patients with ANCA-associated vasculitis (AAV).
Clinical and transcriptomic characterization of mixed granulocytic phenotype in chronic obstructive pulmonary disease.
This post hoc analysis of the DISARM randomized controlled trial examined mixed granulocytic COPD in 54 patients, defined by eosinophils >1% and neutrophils >3% in bronchoalveolar lavage.
Coping With Breathlessness in Individuals With Lung Diseases: A Systematic Review and Meta-Synthesis.
This systematic review and meta-synthesis examined how individuals with lung diseases cope with breathlessness, synthesizing findings from 33 studies.
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