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557 articles
July 202624
Impact of Hemoglobin Improvement on Survival in Patients With Myelofibrosis and Anemia Treated With Momelotinib in the SIMPLIFY-1 and MOMENTUM Trials.
These post hoc analyses of two phase 3 randomised trials examined how quickly patients with myelofibrosis and baseline hemoglobin < 10 g/dL achieved hemoglobin ≥ 10 g/dL with momelotinib, and whether this was associated…
Clinical and Psychological Outcomes After Monoclonal Gammopathy Screening: A Population-Based Screening Study and Subsequent Randomized Trial of Follow-Up.
This nationwide Icelandic population-based screening study, which included a randomized trial of follow-up strategies, assessed clinical and psychological outcomes after monoclonal gammopathy screening.
Magrolimab Plus Azacitidine Versus Placebo Plus Azacitidine in Patients With Untreated Higher-Risk Myelodysplastic Syndromes: The Phase III ENHANCE Study.
The phase III ENHANCE study evaluated the efficacy and safety of magrolimab plus azacitidine versus placebo plus azacitidine in treatment-naïve patients with higher-risk myelodysplastic syndromes.
Randomized phase 2 trial of CPX-351 vs. CLAG-M (cladribine, cytarabine, G-CSF, and mitoxantrone) for medically unfit adults with acute myeloid leukemia or other high-grade myeloid neoplasms.
This randomized phase 2 trial evaluated CPX-351 versus CLAG-M in 60 medically unfit adults with untreated acute myeloid leukemia (AML).
Avatrombopag Versus Placebo for Persistent Chemotherapy-Induced Thrombocytopenia in GI Cancers: The Phase II ACT-GI Trial.
The phase II ACT-GI trial was a multicenter, randomized, double-blind, placebo-controlled study of avatrombopag for persistent chemotherapy-induced thrombocytopenia in patients with GI cancers.
Rivaroxaban Then Aspirin vs. Aspirin Alone after Total Hip or Knee Arthroplasty.
This multicenter, double-blind randomized controlled trial compared aspirin alone with rivaroxaban followed by aspirin for thromboprophylaxis after total hip or knee arthroplasty.
Copper-deficiency anemia and neutropenia during zinc maintenance therapy for Wilson disease associated with persistent strict dietary copper restriction.
A woman in her 60s with Wilson disease, hepatic and neurological involvement, and cirrhosis developed recurrent leukopenia and neutropenia three years after starting zinc maintenance therapy, followed by macrocytosis…
Altered Busulphan Exposure Associated with Concomitant Omeprazole during Hematopoietic Stem Cell Transplantation Conditioning: A Two-Case Report.
Two adult patients with acute myeloid leukemia underwent conditioning with oral busulphan prior to hematopoietic stem cell transplantation.
Prevalence of plasma coagulation deficiencies and antiphospholipid antibodies positivity in the pediatric population of the Małopolska region: A single-center study from a pediatric hospital in Kraków.
This single-center study assessed the prevalence of plasma coagulation disorders and antiphospholipid antibodies in 120 children aged 3-10 years in the Małopolska region.
Intravenous Ferric Derisomaltose Versus Iron Sucrose for Treatment of Iron Deficiency Anemia in Pregnancy: A Randomized, Comparative Trial.
This randomized controlled trial evaluated the effectiveness of intravenous ferric derisomaltose (FDM) compared to iron sucrose (IS) in treating iron deficiency anemia (IDA) in pregnant individuals.
Prepartum acquired hemophilia A: managing a double challenge for mother and child.
This report discusses four cases of antenatally diagnosed acquired hemophilia A, a rare condition during pregnancy that poses risks of hemorrhage for both mother and child.
Dose Optimization of Dasatinib in Chronic-Phase Chronic Myeloid Leukemia: A Systematic Review and Meta-analysis of 50 mg Versus 100 mg Once Daily.
This systematic review and meta-analysis evaluated the efficacy and safety of dasatinib 50 mg versus 100 mg once daily in adults with chronic-phase chronic myeloid leukemia (CP-CML).
18 F-FDG and 68 Ga-Pentixafor PET/CT in a Patient With Castleman Disease.
A patient with Castleman disease presented with multiple cervical lymphadenopathy. Imaging with 18 F-FDG and 68 Ga-pentixafor PET/CT was performed to aid in the differential diagnosis from lymphoma.
18 F-FAPI-04 PET/CT Outperforms 18 F-FDG in Detecting Multiple Muscle and Subcutaneous Adipose Tissue Involvement of Marginal Zone Lymphoma.
A 63-year-old man presented with marginal zone lymphoma (MZL) involving multiple muscles and subcutaneous adipose tissue, a rare occurrence.
Transfer of emicizumab into breast milk in postpartum acquired hemophilia A.
A woman developed acquired hemophilia A (AHA) four months postpartum and was treated with emicizumab while breastfeeding. Analysis of her plasma and breast milk revealed that emicizumab was detectable in breast milk at…
Polatuzumab Vedotin Plus Rituximab, Gemcitabine, and Oxaliplatin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma: Results From the Phase III, Randomized POLARGO Trial.
The phase III, randomized, open-label POLARGO trial compared polatuzumab vedotin plus rituximab, gemcitabine, and oxaliplatin (Pola-R-GemOx) with R-GemOx in patients with relapsed or refractory diffuse large B-cell…
Neuromuscular Changes During the Six-Minute Walk Test in Pediatric Sickle Cell Disease.
This clinical trial examined neuromuscular changes during the six-minute walk test (6MWT) in children and adolescents with sickle cell disease (SCD).
Hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis diagnosed by bone marrow smear microscopy and metagenomic next-generation sequencing: A case report and review of literature.
An immunocompetent patient presented with disseminated histoplasmosis, leading to rapid clinical deterioration and a diagnosis of hemophagocytic lymphohistiocytosis (HLH).
CD7 chimeric antigen receptor T cells in patients with relapsed or refractory CD7-positive acute myeloid leukemia.
This phase I clinical trial evaluated CD7-targeted CAR-T cell therapy in 14 patients with relapsed or refractory CD7-positive acute myeloid leukemia (AML).
Efficacy, Safety, and Treatment-Delivery Feasibility of Autologous Gene Therapy for Sickle Cell Disease: A Systematic Review With Descriptive Synthesis of Clinical Trials.
This systematic review with descriptive synthesis assessed efficacy, safety, and delivery feasibility of autologous gene therapy for sickle cell disease across nine interventional clinical programs and associated…
Comparative Efficacy of Intranasal, Intramuscular, and Intravenous Vitamin B12 Therapy for Hematological Recovery in Vitamin B12 Deficiency Anemia: A Randomized Controlled Trial.
This randomized controlled trial compared the efficacy of intranasal, intramuscular, and intravenous vitamin B12 therapy in 153 adults with vitamin B12 deficiency anemia.
Phase I study of glofitamab in Japanese patients with relapsed or refractory B-cell non-Hodgkin lymphoma.
This Phase I study evaluated the safety, pharmacokinetics, and efficacy of glofitamab in Japanese patients with relapsed or refractory B-cell non-Hodgkin lymphoma.
A Second Report of a Missense Variant in AMMECR1 Causing Midface Hypoplasia, Hearing Impairment, Elliptocytosis, and Nephrocalcinosis: Case Report and Literature Review.
A patient presented with midface hypoplasia, partial hearing impairment, nephrocalcinosis, and elliptocytosis, consistent with the multisystem disorder MFHIEN.
Intravenous iron administration and management of adverse events: a systematic review and Network for the Advancement of Patient Blood Management, Haemostasis and Thrombosis consensus recommendations.
This systematic review by the NATA provides consensus recommendations on the safety of intravenous iron therapy for iron deficiency and iron-deficiency anemia.
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