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470 articles

May 202624

Clinical ResearchCardiologyOpen access

Opioid-free Anesthesia in Cardiac Surgery: The OFACAR Randomized Clinical Trial.

The OFACAR trial was a randomized, controlled, multicenter study involving 320 adults undergoing elective cardiac surgery. It compared opioid-free anesthesia (OFA) to opioid anesthesia.

AnesthesiologyMay 22, 2026Read summary
Clinical ResearchOtolaryngology (ENT)Open access

Adverse Airway Events Following Head and Neck Cancer Reconstruction Without Elective Tracheostomy.

This systematic review and meta-analysis examined adverse airway events (AAEs) in 5,987 patients with head and neck cancer reconstruction managed without elective tracheostomy (ET).

Otolaryngol Head Neck SurgMay 22, 2026Read summary
Clinical ResearchAnesthesiology

Comparison of Smartphone-Based Music and Film Distraction Techniques on Postoperative Pain in Patients Undergoing Elective Surgery.

This randomized controlled trial evaluated the effectiveness of smartphone-based music and film distraction techniques in reducing acute postoperative pain in 104 adults undergoing elective surgery.

Pain Manag NursMay 21, 2026Read summary
Clinical ResearchCardiology

Superficial intercostal plane blocks for post-sternotomy pain control rationale and design for the EPOCH CardioLink-10 randomized clinical trial.

The EPOCH CardioLink-10 trial is a double-blind, placebo-controlled, multicenter randomized trial assessing the impact of continuous bilateral superficial parasternal intercostal plane (SPIP) blocks on opioid…

Curr Opin CardiolMay 20, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Hydroxyethyl Starch and Perioperative Complications: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis evaluated the impact of hydroxyethyl starch (HES 130/0.4) on renal injury in surgical patients, incorporating data from 114 trials with 13,951 patients.

AnesthesiologyMay 20, 2026Read summary
Clinical ResearchAnesthesiology

Preoperative Olanzapine and Quality of Recovery after Ambulatory Surgery: A Randomized Clinical Trial.

This randomized controlled trial evaluated the effects of a single preoperative dose of 5 mg olanzapine on recovery quality in 384 female patients aged 18 to 50 undergoing ambulatory surgery.

AnesthesiologyMay 20, 2026Read summary
Clinical ResearchOrthopedic Surgery

A nonopioid multimodal pain protocol achieves equivalent pain control after total shoulder arthroplasty: a randomized controlled trial.

This prospective, single-blinded randomized controlled trial compared postoperative nonopioid multimodal analgesia with an opioid-containing regimen after primary anatomic or reverse total shoulder arthroplasty.

J Shoulder Elbow SurgMay 19, 2026Read summary
Clinical ResearchAnesthesiology

Wrist-Ankle Acupuncture on Postoperative Nausea and Vomiting Prophylaxis in High-Risk Female Patients: A Pragmatic, Randomized, Single-Blind, Sham-Controlled Trial.

This randomized controlled trial assessed the effectiveness of wrist-ankle acupuncture (WAA) for preventing postoperative nausea and vomiting (PONV) in high-risk female patients undergoing elective surgery.

J Invest SurgMay 18, 2026Read summary
Clinical ResearchNeurosurgeryOpen access

Efficacy of Dexmedetomidine in Preventing Postoperative Delirium in Patients Undergoing Brain Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

This systematic review and meta-analysis assessed perioperative dexmedetomidine for preventing postoperative delirium in adults undergoing brain surgery. It included five randomized controlled trials with 646 patients.

Neurocrit CareMay 18, 2026Read summary
Clinical ResearchEmergency Medicine

The effect of peripheral vasopressor protocols on extravasation rates: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the impact of peripheral vasopressor protocols on extravasation rates in critically ill patients.

J Crit CareMay 17, 2026Read summary
Clinical ResearchEmergency Medicine

Systematic Review of Pediatric Ketamine in Emergency Department Procedural Sedation: Frequency and Predictors of Adverse Events.

This systematic review analyzed 20 studies involving 58,752 children to assess the frequency of adverse events associated with intravenous ketamine sedation in pediatric emergency departments.

Ann Emerg MedMay 15, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Impact on analgesia, diaphragmatic function, and recovery between erector spinae plane block versus superior trunk block in arthroscopic shoulder surgery: a randomized controlled trial.

This randomized controlled trial compared the erector spinae plane block and superior trunk block in 60 patients undergoing arthroscopic shoulder surgery.

Ann MedMay 14, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Effectiveness of erector spinae plane block combined with physical therapy in adult degenerative scoliosis: A randomized controlled trial.

This randomized controlled trial evaluated whether adding an erector spinae plane block to physical therapy improved pain, disability, or quality of life in 26 adults aged 60 and older with degenerative lumbar…

J Back Musculoskelet RehabilMay 14, 2026Read summary
Clinical ResearchAnesthesiology

Meta-Analysis and Meta-Regression of Perioperative Thirst Management Interventions.

This meta-analysis evaluated the effectiveness of nonpharmacological nursing interventions for reducing perioperative thirst severity in surgical patients.

Nurs ResMay 13, 2026Read summary
Clinical ResearchGastroenterologyOpen access

Alfentanil-Propofol Versus Sufentanil-Propofol Sedation on Postoperative Fatigue After Gastrointestinal Endoscopy: A Multicenter Randomized Control Trial.

This multicenter randomized controlled trial evaluated postoperative fatigue (POF) in 248 patients undergoing gastrointestinal endoscopy with either alfentanil-propofol or sufentanil-propofol sedation.

Dig Dis SciMay 13, 2026Read summary
Clinical ResearchAnesthesiology

Glucocorticoid-Enhanced Fascial Plane and Peripheral Nerve Blocks Versus Periarticular and Local Infiltration Analgesia in Total Hip Arthroplasty: A Prospective Randomized Controlled Trial.

This prospective randomized controlled trial compared anterior quadratus lumborum plus lateral femoral cutaneous nerve blocks (aQLB+LFCNB) with periarticular and local infiltration analgesia (PALIA) in patients…

J Bone Joint Surg AmMay 13, 2026Read summary
Clinical ResearchAnesthesiology

Comparison of Paravertebral Block and Erector Spinae Plane Block in Thoracotomy Using Nociception Level Index Monitoring: A Prospective Randomized Trial.

This prospective randomized trial compared the analgesic efficacy of paravertebral block (PVB) and erector spinae plane block (ESPB) in 57 patients undergoing elective thoracotomy.

J Cardiothorac Vasc AnesthMay 12, 2026Read summary
Clinical ResearchAnesthesiology

Impact of information delivery mode on postoperative comprehension and anxiety following mandibular third molar extraction: a randomized pilot study comparing a narrated audiovisual tool to a written leaflet.

This randomized controlled trial evaluated the impact of a narrated audiovisual tool versus a written leaflet on postoperative comprehension and anxiety in 200 patients undergoing mandibular third molar extraction.

J Stomatol Oral Maxillofac SurgMay 12, 2026Read summary
Clinical ResearchGastroenterology

High-Flow Nasal Cannula in Subjects Undergoing Endoscopy With Intravenous Sedation.

This single-center randomized trial compared conventional nasal oxygen with high-flow nasal cannula (HFNC) at two flow rates in 60 low-risk subjects undergoing ERCP with deep intravenous sedation.

Respir CareMay 12, 2026Read summary
Clinical ResearchAnesthesiology

Meta-Analysis of PENG+LFCN versus FICB on ERAS-Related Outcomes: Postoperative Pain, Motor Function and Recovery in Hip Surgery.

This meta-analysis compared the efficacy of pericapsular nerve group block combined with lateral femoral cutaneous nerve block (PENG+LFCN) versus fascia iliaca compartment block (FICB) for postoperative pain management…

J Invest SurgMay 11, 2026Read summary
Clinical ResearchCardiology

Early Enteral Levothyroxine as Rescue Therapy in Cardiac Surgery Patients With Delayed Neurologic Recovery: A Randomized Trial.

This randomized controlled trial evaluated early enteral levothyroxine as a rescue therapy for delayed neurologic recovery in 70 adults post-cardiac surgery.

J Cardiothorac Vasc AnesthMay 11, 2026Read summary
Clinical ResearchCardiology

Anticholinergic Burden as a Modifiable Risk Factor in Cardiac Surgery: A Randomized Controlled Study.

This randomized controlled trial evaluated the impact of reducing perioperative anticholinergic burden on functional recovery in 122 older patients (≥60 years) undergoing coronary artery bypass grafting (CABG).

J Cardiothorac Vasc AnesthMay 8, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Effect of dexmedetomidine on cerebral homeostasis in patients undergoing craniotomy for brain tumour excision: A randomized double-blind trial.

This randomized double-blind trial evaluated the effects of dexmedetomidine (DEX) on cerebral homeostasis in 56 patients undergoing craniotomy for brain tumor excision.

Br J Clin PharmacolMay 8, 2026Read summary
Clinical ResearchCardiologyOpen access

Short- and Long-term Efficacy and Safety of Levosimendan in Veno-arterial Extracorporeal Membrane Oxygenation Weaning: The WEANILEVO Randomized Double-blind Multicenter Trial.

The WEANILEVO study was a multicenter, double-blind, randomized controlled trial assessing the efficacy and safety of levosimendan in 80 patients undergoing weaning from veno-arterial extracorporeal membrane oxygenation…

AnesthesiologyMay 8, 2026Read summary

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