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845 articles
September 202624
Somatic PIK3CA and PTEN mutations with endothelial PI3K/AKT/mTOR activation in RAS-negative brain arteriovenous malformations.
This report details two autopsy-confirmed brain arteriovenous malformations (bAVMs) with somatic PIK3CA mutations, one of which also had a PTEN alteration.
Diagnostic Strategies After Negative Colposcopy in High-Grade Cervical Cytology: A Multicenter Randomized Trial.
This multicenter randomized trial evaluated diagnostic strategies for detecting HSIL+ in women with high-grade cervical cytology and negative colposcopy.
Beyond β-amyloid: transthyretin cerebral amyloid angiopathy.
A 44-year-old man presented with recurrent upper-limb and perioral sensory symptoms, later identified as transient focal neurological episodes.
Primary ALK-positive anaplastic large cell lymphoma of the urinary bladder in a pediatric patient: a case report and review of literature.
A 14-year-old male presented with several months of gross hematuria that became painful. Imaging revealed a mass-like thickening of the anterior bladder wall, and cystoscopy identified a 3.5-cm pedunculated lesion.
Concurrent follicular lymphoma and follicular dendritic cell sarcoma: composite neoplasm or transdifferentiation?
A 52-year-old woman presented with night sweats, weight loss, and an obstructing colonic mass with mesenteric disease. Biopsy revealed two distinct tumor populations: one consistent with follicular large B cell lymphoma…
Perineural invasion and Schwann cell-like phenotypic changes in head and neck adenoid cystic carcinoma: A systematic review and meta-analysis.
This systematic review and meta-analysis examined perineural invasion (PNI) and Schwann cell-like phenotypic changes in head and neck adenoid cystic carcinoma (ACC).
Western versus Asian utilization of molecular testing for indeterminate thyroid nodules: A meta-analysis of divergent clinical impact.
This meta-analysis examined the use of molecular testing (MT) for indeterminate thyroid nodules in Western and Asian populations.
Unusual pelvic mass in a young adult: prostatic Ewing's sarcoma with distant metastases.
A man in his 20s presented with urinary obstruction, constipation, and leg pain. Imaging revealed a bulky pelvic mass from the prostate, leading to bilateral hydroureteronephrosis.
Pure Red Cell Aplasia Following Neoadjuvant Docetaxel/Carboplatin/Trastuzumab (TCbH) in a 45‑Year‑Old Woman With Breast Cancer Successfully Treated With Cyclosporine.
A 45-year-old woman with HER2-positive breast cancer developed pure red cell aplasia (PRCA) after neoadjuvant treatment with docetaxel/carboplatin/trastuzumab.
Fourteen-Year Course of Multiple Recurrent and Distantly Metastatic Hepatic Epithelioid Hemangioendothelioma With Serial Ki-67 Evolution: A Case Report.
A 48-year-old woman with hepatic epithelioid hemangioendothelioma (HEHE) underwent right partial hepatectomy after a liver lesion was found incidentally. Histological analysis confirmed the diagnosis.
Mucinous adenocarcinoma presenting as adult colonic intussusception: A case report.
A 75-year-old woman with multiple comorbidities presented with hematochezia, abdominal distension, intermittent colicky pain, and weight loss.
Giant subpatellar synovial osteochondromatosis complicated by osteoarthritis of the knee: A case report.
A 71-year-old woman presented with a 2-year history of progressive pain and swelling in her left knee, leading to significant movement restriction and impairment in daily activities.
Lymphocutaneous sporotrichosis: A case report from southeastern China and review of the literature.
A 53-year-old male presented with multiple ulcerated lesions, leading to a diagnosis of lymphocutaneous sporotrichosis. Pathological analysis showed an inflammatory reaction, while imaging studies were normal.
A case report: an unusual case of ulcerative intestinal IgG4-related disease with clinical features overlapping with probable intestinal Behcet's disease.
A 62-year-old man with a history of recurrent oral ulcers presented with sudden hematochezia and hypovolemic shock. Imaging showed sclerosing mesenteritis, and endoscopy revealed multiple small intestinal ulcers.
Acute oral Chagas disease following armadillo blood ingestion: a case report.
A 70-year-old man from rural Colombia presented with atrial fibrillation, dyspnea, and palpitations. A blood smear identified Trypanosoma cruzi, confirmed by molecular testing, linked to his ingestion of armadillo blood…
A complex military repatriation cold case assisted by craniofacial superimposition.
Partially skeletonized remains recovered near the Pusan Perimeter in 1950 were initially unidentified, returned to the United States, and interred in Hawaii.
A novel homozygous chromosomal deletion encompassing the ACTL9 gene is associated with cIVF polyspermy and male infertility.
An infertile man with polyspermy during conventional in vitro fertilization (cIVF) and nearly total fertilization failure after intracytoplasmic sperm injection (ICSI) was found to have a homozygous chromosomal…
Embryological and Pathophysiological Perspectives on a Rare Association of Sirenomelia with Anencephaly and Spina Bifida.
A reported fetus had sirenomelia, with a single lower limb, together with anencephaly and spina bifida. Fetal dissection identified a single kidney and ureter, as well as an inflated, blind-ending sigmoid colon.
Lung Adenocarcinoma Presenting as Bilateral Nonresolving Pneumonia Mimicking Pulmonary Infection.
A 63-year-old nonsmoking woman presented with chronic cough, low-grade fever, progressive weight loss, and worsening breathlessness.
Adulthood interstitial lung disease due to variants in surfactant related genes: A systematic review.
This systematic review examined the clinical features of interstitial lung disease/pulmonary fibrosis (ILD/PF) in adults with surfactant-related gene (SRG) variants.
Lacrimal Gland Choristoma and Associated Ocular Anomalies: A Review and Description of a Bilateral Gland Choristoma With Unique Features.
A young female presented with bilateral epibulbar lacrimal gland choristoma, which was associated with a limbal dermoid and ocular colobomatous anomalies.
Primary Orbital Melanoma: A Systematic Review of Clinical Characteristics, Management and Outcomes.
This systematic review evaluated clinical characteristics, management, and outcomes of 112 patients with histopathologically confirmed primary orbital melanoma (POM).
Accessory cavitated uterine mass presenting as refractory dysmenorrhoea: a diagnostic challenge.
A woman in her 20s presented with severe progressive dysmenorrhoea that began within 1-2 years of menarche, was refractory to medical therapy and required repeated emergency department visits for parenteral analgesia.
Jejunal metastatic melanoma presenting with occult gastrointestinal haemorrhage and refractory anaemia.
An elderly man with a history of cutaneous melanoma presented with chronic iron-deficiency anemia and weight loss. Imaging and endoscopy failed to provide a definitive diagnosis, revealing only an aneurysmal jejunal…
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