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1320 articles
October 202619
Pearls & Oy-sters: Diagnosis of Pediatric Tumefactive Multiple Sclerosis With MRI Biomarkers.
A 16-year-old boy presented with subacute headaches, cognitive difficulties, dizziness, blurry vision, right arm weakness, numbness, and gait issues.
Guillain-Barré syndrome temporally associated with respiratory syncytial virus vaccination.
An older woman experienced acute progressive limb weakness, pain, and paraesthesia two weeks post-respiratory syncytial virus vaccination.
MicroRNAs Regulation of Axon Sprouting in Peripheral Nerve Regeneration: A Systematic Review.
This systematic review examines the role of microRNAs (miRNAs) in peripheral nerve regeneration, focusing on miR-21, miR-133b, miR-124, and miR-30b.
Apheresis-Triggered Torsades De Pointes in Congenital Long QT Syndrome Type 2: Citrate-Related Arrhythmia Risk and Safe Modality Switching During Myasthenic Crisis.
A 44-year-old woman with congenital long QT syndrome Type 2 presented in myasthenic crisis due to anti-MuSK-positive myasthenia gravis.
Intrathecal Allogeneic B7-H3-Targeted CAR γδ T Cells for Leptomeningeal Metastasis from Solid Tumors: Safety, Efficacy, and Immunologic Dynamics in a Phase I Trial.
This phase I trial evaluated the safety and efficacy of intrathecal QH104, an allogeneic B7-H3-targeted CAR γδ T-cell therapy, in 3 patients with leptomeningeal metastasis from solid tumors.
Temporal Net Water Uptake Evolution and Its Association with Functional Outcome in Acute Ischemic Stroke.
This multicenter randomized controlled trial examined the relationship between temporal changes in net water uptake (NWU) and functional outcomes in 115 patients with acute ischemic stroke.
Fibrin-Heparin-Coated Intracranial Stents as Salvage Therapy in Pediatric Focal Cerebral Arteriopathy-Inflammatory Type.
A 13-year-old boy presented with progressive arterial ischemic stroke due to focal cerebral arteriopathy inflammatory type.
Systematic Review and Meta-Analysis on Rescue Stenting for Large Vessel Occlusion Due to Underlying Intracranial Atherosclerotic Stenosis.
This systematic review and meta-analysis evaluated the efficacy and safety of rescue stent placement in patients with large vessel occlusion (LVO) due to intracranial atherosclerotic stenosis (ICAS).
Pediatric Guillain-Barré Syndrome Post Organ Transplant: Acute and Chronic Complication Requiring High Index of Suspicion.
Two pediatric patients developed Guillain-Barré syndrome (GBS) following organ transplantation. The first patient experienced rapid weakness post-liver transplant amid organ failure and adenovirus infection, showing…
A Novel BORCS5 Loss-Of-Function Variant in a Patient With a Rare Neurodevelopmental Disorder.
The BORCS5 is an important and critical component of the BLOC-one-related complex (BORC), involved in kinesin-dependent anterograde lysosomal transport.
TMS-Derived Neurophysiological Measures of Corticospinal Excitability, Intracortical Excitability, and Interhemispheric Interactions Associated With Post-Stroke Motor Recovery: A Systematic Review.
This systematic review evaluated the relationship between TMS-derived neurophysiological measures and motor recovery in adults post-stroke, synthesizing data from 16 randomized controlled trials.
Health Economic & Implementation Determinants of Prehospital Stroke Triage Tools: A Systematic Review.
This systematic review evaluated health economic outcomes and implementation determinants of prehospital triage tools for suspected ischaemic stroke patients.
A Case of Primary Intramedullary Infantile Fibrosarcoma With an RBPMS::NTRK3 Fusion and Response to Larotrectinib.
A 4-week-old infant presented with rapidly progressive cervical myelopathy due to primary intramedullary infantile fibrosarcoma.
NIHSS and Large Artery Atherosclerosis Affect Efficacy of Dual Antiplatelet Therapy Versus Alteplase for Minor Stroke.
This randomized controlled trial analyzed the efficacy of dual antiplatelet therapy (DAPT) versus alteplase in patients with minor stroke (NIHSS 0-5) and assessed the impact of large artery atherosclerosis (LAA).
Longitudinal clinical outcomes after amyloid clearance in aducanumab phase 3 studies.
This exploratory analysis pooled participants from the randomized phase 3 ENGAGE and EMERGE aducanumab trials who entered a long-term extension or later redosing study.
Dose Considerations and Generalization Following Script Training for Poststroke Aphasia: A Randomized Factorial Clinical Trial.
This single-site, single-blind, 2 × 2 factorial randomized controlled trial examined how script length and session frequency affect treatment outcomes in 85 people with chronic poststroke aphasia.
Sensory processing and executive functioning interaction in neurodevelopmental disorders and at-risk conditions: A systematic review and meta-analysis.
This systematic review and meta-analysis examined associations between sensory processing (SP) and executive functioning (EF) in children and adolescents aged 0–18 with neurodevelopmental disorders or at-risk…
Persistent influenza A RNA detection in a fatal pediatric case of influenza-associated encephalopathy.
A 9-year-old boy developed fulminant influenza-associated encephalopathy, a life-threatening complication of influenza. Despite life-sustaining support, intensive immunomodulatory treatment, and antiviral therapy…
Feasibility of using Making Mindfulness Matter© for children with epilepsy and their parents: A pilot randomized controlled trial.
This parallel, 1:1 pilot randomized controlled trial assessed whether an eight-week, live-online family mindfulness program could be delivered to children with epilepsy aged 4–10 years and their parents in Ontario…
September 20265
Continuous Intravenous Acyclovir as Outpatient Parenteral Antimicrobial Therapy for HSV and VZV Neurological Infections: A Case Series With Pharmacokinetic and Cost Evaluation, and Review of Literature.
This case series involved eight patients with neurological infections caused by HSV or VZV who transitioned to continuous intravenous acyclovir via an outpatient parenteral antimicrobial therapy (OPAT) program after…
Repetitive Transcranial Magnetic Stimulation Combined With Median Nerve Electrical Stimulation for Severe Traumatic Brain Injury.
This randomized controlled trial investigated the effects of repetitive transcranial magnetic stimulation (rTMS) combined with median nerve electrical stimulation (MNS) in 86 patients with severe traumatic brain injury…
Right Brain: Language Without Speech.
During a neurology rotation as a second-year internal medicine resident, I encountered a preschool-aged child whose absence of spontaneous speech initially framed my clinical thinking.
Clinical Reasoning: A 60-Year-Old Woman With Fever, Headache, Diplopia, and Unilateral Periorbital Swelling.
A 60-year-old woman presented with fever, headache, horizontal diplopia, and unilateral periorbital swelling after experiencing recurrent gingival swelling and pain for about a month.
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder and skin changes) associated with Castleman disease and latent tuberculosis: a diagnostic challenge.
A woman in her 40s presented with progressive multisystem disease, including chronic distal neuropathy, constitutional decline, lymphadenopathy, and serosal effusions.
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