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1003 articles
September 202624
Aggressive brainstem listeria abscess in an immunocompetent individual: A case report.
An immunocompetent patient in their late 50s presented with neurolisteriosis characterized by multifocal brainstem abscesses. The case involved an extensive negative infectious workup and a complex antibiotic regimen.
Lower Limb Necrotizing Soft Tissue Infection Associated with Corynebacterium minutissimum in an Adolescent: A Case Report and Surgical Management.
A 14-year-old boy presented with progressive ulceration, swelling, and malodor in the left lower leg, leading to a diagnosis of necrotizing soft tissue infection (NSTI).
Lymphocutaneous sporotrichosis: A case report from southeastern China and review of the literature.
A 53-year-old male presented with multiple ulcerated lesions, leading to a diagnosis of lymphocutaneous sporotrichosis. Pathological analysis showed an inflammatory reaction, while imaging studies were normal.
First reported human Castellaniella defragrans bacteraemia: a case report.
An 82-year-old man with monoclonal B-cell lymphocytosis, later diagnosed with chronic lymphocytic leukaemia, presented with fever, confusion, and signs of sepsis.
An unusual cause of a necrotic bullous skin lesion: a case report.
A man in his 30s presented with a necrotic bullous lesion on his right palm and ipsilateral lymphadenopathy after contact with a hare carcass in Canada. Initial treatment with a cephalosporin was ineffective.
Acute oral Chagas disease following armadillo blood ingestion: a case report.
A 70-year-old man from rural Colombia presented with atrial fibrillation, dyspnea, and palpitations. A blood smear identified Trypanosoma cruzi, confirmed by molecular testing, linked to his ingestion of armadillo blood…
Possible correlation between Mycobacterium abscessus subsp. massiliense spondylodiscitis and spinal anesthesia: Diagnostic and therapeutic challenges.
A 57-year-old man experienced back pain following spinal anesthesia for prostate surgery. Six months later, he underwent decompressive laminectomy, with initial cultures negative for mycobacteria.
Sequential combination of anti-PD-1 antibody and PEG-IFNα in chronic hepatitis B patients: correlates of HBsAg loss with enhanced T-cell responses.
This pilot clinical trial investigated the sequential combination of anti-PD-1 antibody (sintilimab) and PEG-IFNα in ten virologically suppressed chronic hepatitis B patients.
Losartan with add-on spironolactone for severe COVID-19 in the intensive care unit: a randomized controlled trial.
This randomized, open-label, parallel-group trial at five intensive care units in Marseille evaluated losartan, with conditional spironolactone, added to standard care for adults with severe COVID-19-related respiratory…
Late Presentation of Lutembacher Syndrome with Severe Pulmonary Hypertension and Tricuspid Regurgitation Complicated by Lower Respiratory Tract Infection in an Elderly Female: A Fatal Case Report.
A 68-year-old woman with two years of progressive breathlessness presented with recent worsening, productive cough and bilateral pedal edema.
Associations Between Gut Microbiota and Immune Profiles in Community-Dwelling Older Adults and the Regulatory Role of Polygonatum odoratum.
This randomized controlled trial investigated the effects of Polygonatum odoratum on gut microbiota and immune profiles in 140 community-dwelling older adults aged 60 and above over 90 days.
Recurrent hydronephrosis and catheter blockage, secondary to an organised bacterial mass within the bladder.
An elderly man with a history of chronic kidney disease and a long-term catheter presented with urosepsis and recurrent catheter blockages.
A case of membranous nephropathy during asymptomatic syphilis.
A 51-year-old woman presented with weight gain and leg edema, leading to a diagnosis of nephrotic syndrome. Laboratory tests revealed low serum protein and heavy proteinuria.
Surveillance of antibiotic-resistant bacteria integrating whole genome sequencing and epidemiological information - a global, systematic review, 2012-2023.
This systematic review examined global surveillance systems for antibiotic-resistant bacteria (ARB) integrating whole genome sequencing (WGS) and epidemiological data.
Advanced Eumycetoma of the Right Foot Resulting in Below-Knee Amputation in Somalia: A Case Report.
A 33-year-old man from Somalia presented with a seven-year history of progressive swelling in the right foot, characterized by massive tumefaction and multiple discharging sinuses containing black grains.
Asymptomatic tuberculosis among household contacts of active pulmonary tuberculosis cases: a systematic review and meta-analysis.
This systematic review and meta-analysis estimated the prevalence of asymptomatic tuberculosis (TB) among household contacts of people with active pulmonary TB.
Fatal case of severe fever with thrombocytopenia syndrome complicated by profound neutropenia and invasive trichosporonosis.
A 71-year-old woman initially treated with corticosteroids and etoposide for clinically diagnosed hemophagocytic lymphohistiocytosis was transferred and diagnosed with severe fever with thrombocytopenia syndrome (SFTS)…
Integrating long-acting injectable cabotegravir for HIV prevention into the Brazilian public health system (ImPrEP CAB Brasil): a hybrid type-2 implementation-effectiveness cohort study.
This multicentre, open-label hybrid type-2 implementation-effectiveness cohort study assessed same-day long-acting injectable cabotegravir (CAB-LA) delivery at 14 Brazilian public health services among PrEP-naive people…
Unilateral Iris Mass Lesions in Presumed Ocular Tuberculosis.
A 36-year-old man presented with 15 days of right-eye redness, pain, and reduced vision. Examination showed granulomatous anterior uveitis, two lobulated iris masses, and 360° posterior synechiae.
Pulmonary Dirofilaria immitis Infection and Concurrent Pleural Lymphangiomatosis in a Young Woman from Costa Rica: A Diagnostic Challenge after 20 Years of Silence.
A woman from Costa Rica presented with respiratory distress, marked eosinophilia (47%), and severe chylothorax. Pleural biopsies showed a lymphoplasmacytic reaction with eosinophils; molecular analysis of…
Safety and Immunogenicity of a PD-1-Enhanced HIV-1 Therapeutic DNA Vaccine: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Clinical Trial in People With HIV-1 on Antiretroviral Therapy.
This randomized, double-blind, placebo-controlled phase I trial evaluated the safety and immunogenicity of ICVAX™, a PD-1-enhanced HIV-1 therapeutic DNA vaccine, in 45 adults with HIV-1 on antiretroviral therapy.
Switching to Daily Doravirine/Islatravir (100/0.25 mg) Maintains Viral Suppression Through Week 48 Despite Baseline Non-Nucleoside Reverse Transcriptase Inhibitor Resistance-Associated Mutations or M184I/V in Proviral DNA.
This phase III clinical trial evaluated the effects of baseline resistance-associated mutations (RAMs) on the virologic response to doravirine/islatravir (DOR/ISL) in 1227 virologically suppressed adults with HIV-1.
In Host Mutational Adaptation of Mycobacterium Tuberculosis Complex Strains During Tuberculosis Infection.
This meta-analysis examined 5882 Mycobacterium tuberculosis complex (MTBC) genomes from 1044 patients to identify mutations associated with drug resistance during tuberculosis infection.
Effect of Delayed Antiretroviral Therapy Initiation on Anti-CD4 Autoantibodies in Antiretroviral Therapy-Naive People With HIV.
This randomized controlled trial investigated the effect of delayed antiretroviral therapy (ART) initiation on anti-CD4 autoantibodies in ART-naive individuals with HIV and CD4 > 500 cells/µL.
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