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557 articles
August 202624
Successful treatment of refractory hemophagocytic lymphohistiocytosis complicating Epstein-Barr virus-positive classic Hodgkin lymphoma with rituximab.
A male in his early 70s with advanced EBV-positive mixed-cellularity classic Hodgkin lymphoma presented with cervical lymphadenopathy, fever, and hepatosplenomegaly.
Severe Plasmodium falciparum malaria with marked ADAMTS13 reduction and secondary microangiopathic features: A case report.
A 46-year-old man returning from Nigeria presented with severe Plasmodium falciparum malaria after 11 days of intermittent fever, jaundice, and dark urine.
Prevalence and Clinical Relevance of Antiphospholipid Antibodies in Ischemic Stroke: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined the prevalence of antiphospholipid antibodies (aPL) in patients with ischemic stroke. Among 9438 patients, the pooled prevalence of aPL seropositivity was 19.1%.
HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities.
HOPE Kids 2 was a phase 3, multicenter, double-blind, placebo-controlled randomized trial of voxelotor in children aged 2 to <15 years with sickle cell disease (HbSS/HbSβ⁰) and conditional cerebral blood flow velocities…
Long-Term Restoration of Anticoagulant Function After Liver Transplantation for Severe Congenital Protein C Deficiency: A Single-Center Experience Involving Three Pediatric Patients.
Three pediatric patients with severe congenital protein C deficiency underwent liver transplantation, resulting in plasma protein C activity levels exceeding 64% post-surgery.
Risk factors for invasive yeast infections in adult patients with hematological malignancies and/or stem cell transplant: systematic literature review and meta-analysis.
This systematic review and meta-analysis examined risk factors for invasive yeast infections (IYI) in adults with hematological malignancies or undergoing hematopoietic stem cell transplantation.
Cardiac Adverse Events in Patients With Chronic Lymphocytic Leukemia Treated With First-Line Ibrutinib-Venetoclax.
This systematic review and meta-analysis assessed cardiac adverse events with first-line ibrutinib-venetoclax (IV)-based therapy for chronic lymphocytic leukemia or small lymphocytic lymphoma.
Effect of adding umbilical cord blood derived stem cells to haploidentical stem cell transplant (haplo-cord) on post-transplant survival and graft-versus-host disease in patients with hematological malignancies: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of adding umbilical cord blood-derived stem cells to haploidentical stem cell transplantation (haplo-cord) in patients with hematological malignancies.
Secondary Hemophagocytic lymphohistiocytosis in an immunocompetent adult: a case report distinguishing sarcoidosis from histoplasmosis.
A 73-year-old immunocompetent male presented with lethargy and poor oral intake, initially diagnosed with sarcoidosis. Clinical evaluation revealed fever, splenomegaly, pancytopenia, and elevated inflammatory markers.
SHR-2004, a Humanized Monoclonal Antibody Targeting Factor XI, for Preventing Venous Thromboembolism After Ovarian Cancer Surgery: A Randomized, Active-Controlled Phase 2 Study.
This multicenter, open-label, randomized Phase 2 trial compared the factor XI-targeting antibody SHR-2004 with enoxaparin followed by rivaroxaban for postoperative venous thromboembolism (VTE) prevention in patients…
Acute development of EBV+ T-cell lymphoproliferative disorder after treatment with rituximab for follicular lymphoma.
An elderly patient developed an EBV-positive T-cell lymphoproliferative disorder (LPD) following treatment with rituximab for follicular lymphoma.
Consolidation Therapy Based on Mutation Clearance in Acute Myeloid Leukemia.
This phase II multicenter trial evaluated the impact of leukemia-associated mutation (LAM) clearance on relapse-free survival (RFS) in 100 patients aged 18-60 with intermediate-risk acute myeloid leukemia (AML) in first…
The role of antifactor Xa monitoring in the dosing and administration of low-molecular-weight heparins in pregnancy: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed thromboembolic complications and major bleeding with fixed, weight-based, and anti-Xa-monitored low-molecular-weight heparin dosing during pregnancy, including use for…
Peripheral and splanchnic venous thromboembolism in acute and infected necrotizing pancreatitis: A systematic review and meta-analysis.
This systematic review and random-effects meta-analysis pooled venous thromboembolism incidence after acute necrotizing pancreatitis, including an infected-necrosis subgroup.
A Phase IIa, Double Blind, Randomized, Placebo Controlled, Parallel, Multicentre, Proof-of-Concept Study to Evaluate the Efficacy and Safety of Desidustat Oral Tablet for Treatment of Sickle Cell Disease.
This phase IIa, double-blind, randomised, placebo-controlled, multicentre proof-of-concept trial assessed oral desidustat in 24 Indian adults with sickle cell disease.
Fecal filtrate transplantation as salvage therapy for fulminant Clostridioides difficile infection in adult hematological patients during chemotherapy-induced aplasia: a pilot experience.
Fulminant Clostridioides difficile infection (CDI) in patients with hematologic malignancies during chemotherapy-induced aplasia carries high mortality and limited treatment options.
ERG and CD31 expression in acute megakaryoblastic leukemia and myeloid sarcoma: A diagnostic pitfall.
A case of acute megakaryoblastic leukemia (AMKL) presented as a soft tissue mass was misdiagnosed as composite hemangioendothelioma due to the co-expression of ERG and CD31.
Indirect treatment comparisons find enhanced effectiveness of pegcetacoplan versus crovalimab in both complement inhibitor-naïve and -experienced patients with paroxysmal nocturnal hemoglobinuria.
This Phase III randomized controlled trial evaluated the effectiveness of pegcetacoplan versus crovalimab in patients with paroxysmal nocturnal hemoglobinuria (PNH), both C5 inhibitor-naïve and experienced.
Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis.
The MAIA randomised controlled trial compared daratumumab plus lenalidomide and dexamethasone (D-Rd) with lenalidomide and dexamethasone (Rd) in transplant-ineligible adults with newly diagnosed multiple myeloma.
Raccoon eye as the sole presenting sign of AL amyloidosis associated with a low-burden clonal plasma cell neoplasm.
A 60-year-old woman presented with recurrent periorbital purpura, known as 'raccoon eyes,' as the sole clinical manifestation.
Gelatinous transformation and concomitant fibrosis of bone marrow in a patient with relapsed myelodysplastic syndrome following unrelated bone marrow transplantation.
A 69-year-old woman with myelodysplastic syndrome (MDS) underwent unrelated bone marrow transplantation and initially achieved complete remission.
Multifocal Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, Presenting on Face and Chest: Complete Remission With R-CHOP.
A 79-year-old woman developed rapidly enlarging erythematous-to-violaceous tumors and plaques on her face, chest, left upper arm, and upper back.
Risk of post-acute symptoms and conditions after SARS-CoV-2 compared with other respiratory viral infections: a systematic review and meta-analysis.
This systematic review and meta-analysis compared persistent symptoms and conditions in adults after SARS-CoV-2 infection with those following other acute respiratory viral infections.
Benefit-risk of voxelotor, crizanlizumab, and l-glutamine in sickle cell disease: A systematic review.
This systematic review assessed clinical evidence for l-glutamine, crizanlizumab, and voxelotor in sickle cell disease, distinguishing core randomized evidence from supportive and follow-up reports.
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