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464 articles

August 202624

Case ReportInfectious Diseases

Virological reactivation of the hepatitis B virus after simplification of antiretroviral treatment.

Two patients living with HIV and isolated anti-HBc positivity experienced hepatitis B virus (HBV) reactivation after simplifying their antiretroviral therapy (ART) to regimens without anti-HBV activity.

Enferm Infecc Microbiol Clin (Engl Ed)Aug 14, 2026Read case
Case ReportPathology (Anatomic & Clinical)

Kikuchi-Fujimoto Disease - A Case Report in a Middle-aged Adult.

A 46-year-old woman presented with fever and left posterior cervical lymphadenopathy of 2 weeks’ duration. Tuberculosis testing, including GeneXpert, Mantoux testing, and culture, was negative.

Ann Afr MedAug 14, 2026Read case
Clinical ResearchGastroenterology

Efficacy and safety of pantoprazole for stress-ulcer prophylaxis in critically ill patients: A systematic review and Meta-analysis of randomized controlled trials.

This systematic review and meta-analysis evaluated the efficacy and safety of pantoprazole for stress-ulcer prophylaxis in critically ill patients, including both adults and children.

J Crit CareAug 13, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Acute effects of interrupting prolonged sitting with short bouts of physical activity on postprandial metabolism in sedentary adults: A multi-level meta-analysis.

This systematic review and meta-analysis of randomised cross-over trials assessed acute effects of short activity breaks during prolonged sitting on postprandial metabolism in sedentary adults.

Public HealthAug 13, 2026Read summary
Clinical ResearchNephrology

Cardiometabolic Renal Health Profile, Intensive Blood Pressure-Lowering Treatment and Cognitive Dysfunction: A Post Hoc Analysis of the SPRINT Trial.

This post hoc analysis of the randomised SPRINT trial examined whether baseline cardiometabolic renal health profiles modified cognitive outcomes with intensive blood pressure lowering.

Diabetes Obes MetabAug 12, 2026Read summary
Clinical ResearchPulmonology

Interventions with a significant mortality difference in acute respiratory distress syndrome: A systematic review and comparison with Guidelines.

This systematic review analyzed 33 randomized controlled trials (RCTs) to compare interventions with significant mortality differences in acute respiratory distress syndrome (ARDS) against European and American…

J Crit CareAug 11, 2026Read summary
Clinical ResearchInternal Medicine (General)

suPAR as a circulating inflammatory biomarker: time for translation into clinical practice - A systematic review.

This systematic review examines soluble urokinase-type plasminogen activator receptor (suPAR) as a circulating biomarker, its isoforms, and methods used to measure it.

Clin Chim ActaAug 11, 2026Read summary
Case ReportHematologyOpen access

Analytical interference by IgM paraprotein causing platform-dependent electrolyte discrepancies: a case-based laboratory investigation.

An 85-year-old man presented with low back pain, and laboratory tests revealed significant discrepancies in serum electrolyte and calcium measurements between two platforms.

Biochem Med (Zagreb)Aug 10, 2026Read case
Clinical ResearchEmergency MedicineOpen access

A 1-Hour Resuscitation Bundle for Prehospital Management of Septic Shock.

This multicenter, open-label, cluster-randomized study assessed whether starting a 1-hour resuscitation bundle in the prehospital setting affected 28-day mortality among adults with suspected septic shock managed by…

Crit Care MedAug 10, 2026Read summary
Case ReportInfectious Diseases

Managing HIV in the extreme: Viral load and drug monitoring in a patient with BMI > 60 on long-acting cabotegravir/rilpivirine therapy.

A morbidly obese patient with a BMI of 62 kg/m² and a history of poor adherence to oral antiretroviral therapy presented with unsuppressed HIV viral load.

Br J Clin PharmacolAug 9, 2026Read case
Clinical ResearchPreventive Medicine / Public Health

Telehealth Versus In-Person Care: A Systematic Review of Appointment Attendance and Engagement in Vulnerable Communities.

This systematic review compared objective appointment attendance with telehealth versus in-person care among underserved populations, including rural, low-income, Medicaid-insured, and racial and ethnic minority groups.

Telemed J E HealthAug 9, 2026Read summary
Clinical ResearchInternal Medicine (General)

Exploring the scope and efficacy of nurse navigators in the care of individuals with complex care needs associated with chronic conditions: A systematic review.

This mixed-method systematic review examined the scope and efficacy of nurse navigators for people with complex care needs associated with chronic conditions.

Int J Nurs StudAug 8, 2026Read summary
Clinical ResearchInternal Medicine (General)

The impact of acute sleep fragmentation on muscle blood flow responses to handgrip exercise.

This randomized crossover trial examined the effects of acute sleep fragmentation on muscle blood flow during exercise in 20 adults. Following fragmented sleep, brachial artery dilation decreased (5.5 ± 4.8% vs.

J Appl Physiol (1985)Aug 7, 2026Read summary
Clinical ResearchInternal Medicine (General)Open access

Rethinking Muscle Wasting in Critical Illness: A Systematic Review and Meta-Analysis of Myofiber Size and Protein Turnover.

This systematic review and meta-analysis examined skeletal muscle dysfunction in adults with critical illness, analyzing myofiber size and protein turnover.

Crit Care MedAug 7, 2026Read summary
Clinical ResearchCardiology

Lifestyle modifications in individuals with blood pressure beyond treatment target despite pharmacological treatment: design and baseline characteristics of the MeDiPA randomised controlled trial.

The MeDiPA randomized controlled trial investigates the effects of lifestyle modifications on blood pressure in patients with uncontrolled hypertension despite pharmacological treatment.

Blood PressAug 6, 2026Read summary
Clinical ResearchInfectious Diseases

The effect of metformin on the pharmacokinetics of rifampicin, isoniazid, and pyrazinamide in adults with tuberculosis.

This randomized controlled trial investigated the impact of metformin on the pharmacokinetics of rifampicin, isoniazid, and pyrazinamide in HIV/TB-coinfected adults without diabetes.

Antimicrob Agents ChemotherAug 6, 2026Read summary
Clinical ResearchInternal Medicine (General)

An expanded breakfast buffet increases daily energy and protein intakes in hospitalised patients: A prospective crossover quality improvement study.

This randomized controlled trial evaluated the impact of an expanded breakfast buffet on daily energy and protein intakes in hospitalized patients.

Clin NutrAug 6, 2026Read summary
Clinical ResearchPsychiatry

Efficacy of cannabinoids for insomnia and sleep disturbance: A systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis evaluated the efficacy of cannabinoids for insomnia in 2134 adults across ten randomized controlled trials.

Sleep MedAug 6, 2026Read summary
Clinical ResearchInternal Medicine (General)

Targeted Temperature Management at 35°C vs. 37°C for Heatstroke in ICU: A Pilot Randomized Controlled Trial.

This pilot multicenter randomized controlled trial evaluated targeted temperature management (TTM) at 35°C versus 37°C in 35 intubated heatstroke patients in ICUs across China.

Crit Care MedAug 6, 2026Read summary
Clinical ResearchInfectious Diseases

Interventions to improve viral suppression and adherence to antiretroviral therapy among people living with HIV: a systematic review and network meta-analysis.

This systematic review and network meta-analysis evaluated adherence interventions for antiretroviral therapy among people living with HIV in low- and middle-income countries.

Lancet HIVAug 5, 2026Read summary
Clinical ResearchGastroenterology

Non-aggressive Lactated Ringer's resuscitation improves outcomes and has a favorable safety profile in acute pancreatitis: a comprehensive systematic review and component network meta-analysis of Randomized Controlled Trials using GRADE and CINeMA approaches.

This component network meta-analysis of 12 randomized trials involving 1,216 patients with new-onset acute pancreatitis compared fluid types and resuscitation strategies.

PancreatologyAug 5, 2026Read summary
Clinical ResearchEndocrinologyOpen access

Serum Copeptin Rises After Tolvaptan for Hyponatraemia, but Does Not Predict Risk of Rapid Sodium Rise: Pre-Specified Secondary Analysis of the TVFR Trial.

This study analyzed the effects of tolvaptan on serum copeptin levels in hospitalized patients with hyponatraemia, as part of a pre-specified secondary analysis of a randomized controlled trial.

Clin Endocrinol (Oxf)Aug 3, 2026Read summary
Clinical ResearchGastroenterology

Metabolic ketosis attenuates NLRP3 inflammasome activation and is associated with improvements in hepatic steatosis and liver stiffness in MASLD: a pilot randomized controlled trial.

This pilot randomized controlled trial investigated the effects of a C8-enriched medium-chain fatty acid formulation on metabolic and hepatic outcomes in 20 participants with metabolic dysfunction-associated steatotic…

Int ImmunopharmacolAug 3, 2026Read summary
Clinical ResearchNephrology

Renal Resistive Index Responsiveness to a Mean Arterial Pressure Test As a Guide for Mean Arterial Pressure Target in the Early Phase of Septic Shock: A Physiological Study.

This randomized controlled trial examined the relationship between renal resistive index (RRI) responsiveness to mean arterial pressure (MAP) testing and renal outcomes in patients with early septic shock.

Crit Care MedAug 3, 2026Read summary

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