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1602 articles
October 202624
Artificial Intelligence-Enabled Electrocardiogram Screening for Detection of Low Ejection Fraction in Routine Care: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated randomised controlled trials of AI-enabled ECG screening for low ejection fraction in adults without known heart failure undergoing routine ECGs.
Phase 1 Study of Safety and PK With A Combination of Omeprazole and Trimetazidine for Fatty Acid Oxidation Inhibition in Patients With Advanced Solid Tumors.
This Phase I, open-label, 3 + 3 dose-escalation study assessed safety, tolerability, pharmacokinetics, and preliminary antitumor activity of once-daily oral omeprazole plus trimetazidine, two fatty acid oxidation…
Reducing Central Line-Associated Bloodstream Infections in ICUs: A Systematic Review of Barriers and Facilitators and Intervention Measures.
This PRISMA-guided systematic review examined barriers and facilitators to implementing central line-associated bloodstream infection (CLABSI) prevention among ICU healthcare workers.
Recurrent Angiomyofibroblastoma of the Vulva: MRI Characteristics and Long-Term Monitoring Insights.
A 33-year-old woman presented with a painless, pedunculated right vulvar mass, excised and diagnosed pathologically as angiomyofibroblastoma (AMFB).
Conservative management of disseminated intravascular coagulation caused by uterine leiomyoma degeneration in pregnancy: Case report and review.
A 35-year-old woman at 25 weeks’ gestation presented with lower abdominal pain and a tender 6.5 cm uterine leiomyoma; fetal well-being and placental appearance were normal on ultrasonography.
Integrated management of uterine prolapse during pregnancy: Case report and literature review of successful term delivery following cervical cerclage and pessary utilization.
A 43-year-old woman with recurrent pregnancy losses, including a second-trimester loss attributed to cervical incompetence, presented at 11 weeks’ gestation with stage III uterine prolapse.
Prone positioning and high-frequency oscillatory ventilation in early paediatric acute respiratory distress syndrome (PROSpect): an international, two-by-two factorial, response-adaptive, phase 3, randomised controlled trial.
PROSpect was an international, two-by-two factorial, phase 3 randomised controlled trial comparing prone with supine positioning and high-frequency oscillatory ventilation (HFOV) with conventional mechanical ventilation…
Post-transplant follow-up for kidney transplant recipients: a systematic review of clinical practice guidelines.
This systematic review compared clinical practice guidelines for post-transplant follow-up of kidney transplant recipients, assessing methodological quality and recommendations for surveillance.
Acute kidney injury after aminoglycoside exposure in two cystic fibrosis patients receiving triple CFTR modulator therapy.
Two patients with cystic fibrosis developed acute kidney injury after their first aminoglycoside exposure while receiving triple CFTR modulator therapy.
Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease.
This prospective, parallel-group randomized controlled trial assessed a 12-week telehealth-supported home exercise program in adults aged ≥45 years with non-dialysis stage 4-5 chronic kidney disease.
Voclosporin for the treatment of lupus nephritis flares in patients with inadequate response to mycophenolate mofetil and belimumab: a case series.
This case series describes three patients with lupus nephritis (LN) flares and nephrotic-range proteinuria despite treatment with mycophenolate mofetil and belimumab.
Association of Helicobacter pylori eradication with proteinuria reduction and kidney outcomes: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed whether Helicobacter pylori eradication is associated with renal benefits in people with kidney disease or proteinuria.
Haemodialysis in haemophilia B: a case report. Challenges and strategies from a nephrology perspective.
A 68-year-old man with severe haemophilia B and kidney failure required kidney replacement therapy. He received prophylactic Idelvion® (albutrepenonacog alfa), then underwent arteriovenous fistula creation and started…
First-in-Human Phase 1b/2a Trial Shows Safety with MEK 1/2 Inhibitor EDV2209 as A Novel Treatment for Spontaneous Subarachnoid Hemorrhage.
The STOP-DCI first-in-human Phase 1b/2a interventional, randomized, double-blind, placebo-controlled trial evaluated intracerebroventricular EDV2209, a MEK 1/2 inhibitor, in patients with severe spontaneous subarachnoid…
Survival Outcomes in Metastatic Colorectal Cancer Patients with BRAF Mutations Undergoing Targeted Chemotherapy: A Reconstructed Individual Patient Data Meta-Analysis of Randomized Controlled Trials.
This reconstructed individual patient-data meta-analysis of 18 randomized controlled trials examined survival outcomes across targeted treatment classes in BRAF V600E-mutant metastatic colorectal cancer.
Treatment Procedures for the Edentulous Maxilla: Supplement Report for the First Global Consensus for Clinical Guidelines (GCCG).
The report describes clinical rehabilitation of an edentulous maxilla using implant-supported restorations. It applies the treatment-procedures component of the First Global Consensus for Clinical Guidelines (GCCG)…
Treatment Procedures in the Rehabilitation of the Edentulous Maxilla with an Implant- Supported Fixed Dental Prosthesis-A Case Report.
An edentulous patient underwent rehabilitation of the maxillary arch with an implant-supported fixed dental prosthesis. The report presents the treatment procedures in the context of Global Consensus for Clinical…
Sexual dimorphism and age effects in CKD and type 2 diabetes in the CONFIDENCE trial.
This analysis of the randomized CONFIDENCE trial examined age- and sex-related differences in urinary albumin-to-creatinine ratio (UACR) changes among people with type 2 diabetes and chronic kidney disease receiving…
Acute declines in kidney function with thiazide plus loop diuretics versus loop diuretics alone in acute decompensated heart failure.
This analysis of the randomized CLOROTIC trial examined whether early eGFR changes were associated with outcomes in patients admitted with acute decompensated heart failure and randomized to thiazide or placebo…
Metabolic, hormonal, and reproductive effects of GLP-1 receptor agonizts in hyperandrogenic insulin-resistant women: a systematic review.
This systematic review evaluated GLP-1 receptor agonists for metabolic, hormonal, and reproductive outcomes in adult women with hyperandrogenic insulin-resistant conditions, principally polycystic ovary syndrome and…
Endpoint-specific mortality associated with malignancy among adults with sepsis or septic shock: a systematic review and meta-analysis.
This systematic review and meta-analysis examined mortality among adults with sepsis or septic shock, comparing patients with and without malignancy.
Maternal and Fetal Safety Outcomes of Thrombolytics for Ischemic Stroke in Pregnancy: A Systematic Review and Aggregated Case Series.
This systematic review and Bayesian aggregated case series examined maternal and fetal outcomes after thrombolytic treatment during pregnancy.
Clinical Reasoning: A 60-Year-Old Woman With Progressive Dysarthric Speech and Gait Instability.
A 60-year-old woman developed progressive dysarthria and gait instability over 2 months, with chronic constipation and substantial weight loss.
Digital Health Services and Healthcare Management Outcomes: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed digital health services—including telemedicine, telemonitoring, virtual consultations, and remote care—against conventional care across 21 eligible studies.
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