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1602 articles
November 202624
Safety, Biodistribution, and Dosimetry of FAP and Integrin α v β 3 Dual-Targeting Radioligand 177 Lu-DOTA-FAPI-RGD: Preclinical Validation and First-in-Human Study in Patients with Advanced Adenocarcinomas.
This phase I, first-in-human study evaluated the safety, biodistribution, dosimetry, and preliminary efficacy of the dual-targeting radioligand 177Lu-LNC1009 in nine patients with advanced solid tumors and positive…
Danvatirsen plus Pembrolizumab versus Pembrolizumab for Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma (PEMDA-HN): A Randomized, Phase II Trial.
PEMDA-HN was a multicenter, open-label, randomized phase II trial comparing first-line danvatirsen plus pembrolizumab with pembrolizumab alone in patients with previously untreated, PD-L1-positive recurrent or…
Safety and Efficacy of Intratumoral MEDI1191, an IL12 mRNA Lipid Nanoparticle, plus Intravenous Durvalumab in Patients with Advanced Solid Tumors: A First-in-Human Study.
This open-label, multicenter, first-in-human phase I dose-escalation study evaluated intratumoral MEDI1191, an IL-12 mRNA lipid nanoparticle, with intravenous durvalumab in adults with advanced or metastatic solid…
A Phase II Trial of Pembrolizumab plus Granulocyte-Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer.
This single-center phase II trial evaluated pembrolizumab plus GM-CSF in 42 patients with advanced biliary cancers previously treated with chemotherapy and without prior immune checkpoint inhibitor therapy.
Dual Inhibition of LAG-3 and PD-1 with IBI110 and Sintilimab in Advanced Alveolar Soft Part Sarcoma: A Single-Center, Phase II Trial.
This open-label, single-center phase II trial evaluated IBI110 plus sintilimab in 28 patients with advanced alveolar soft part sarcoma (ASPS), including patients who were naïve or resistant to prior immune checkpoint…
Multikinase Inhibition with Tinengotinib in Advanced Solid Tumors: Results from a Multicenter Phase Ib/II Trial.
This multicenter phase Ib/II trial evaluated tinengotinib’s safety, pharmacokinetics, antitumor activity, and genomic correlates in patients with advanced or metastatic solid tumors lacking standard treatment options.
Neoadjuvant Nivolumab plus Carboplatin and Paclitaxel in Patients with Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck: A Phase II, Single-Arm Trial.
This single-arm, open-label phase II trial evaluated neoadjuvant nivolumab plus carboplatin and paclitaxel in patients with newly diagnosed, locally advanced, resectable head and neck squamous cell carcinoma, including…
Tirzepatide-associated severe euvolemic hyponatremia with syndrome of inappropriate antidiuretic hormone secretion-compatible biochemical features.
A woman with type 2 diabetes and morbid obesity, taking regular insulin and chronic torsemide, developed anorexia, weakness, and drowsiness 10 days after receiving tirzepatide.
Wernicke's encephalopathy secondary to hyperemesis gravidarum in pregnancy.
A 28-year-old woman at 17 weeks’ gestation presented with severe hyperemesis gravidarum and cerebellar dysfunction. She met three of the four European Federation of Neurological Societies diagnostic requirements for…
Proton-pump inhibitor-induced severe hypomagnesemia presenting with seizure and functional hypoparathyroidism: A diagnostic challenge in long-term acid suppression therapy.
A 68-year-old man taking omeprazole 40 mg/day for 8 years presented with a generalized tonic-clonic seizure and neuromuscular irritability.
Role of magnesium as a protective agent in cisplatin-induced nephrotoxicity in head and neck cancer.
This randomized controlled trial evaluated intravenous magnesium sulfate for prevention of cisplatin-induced nephrotoxicity in 100 newly diagnosed patients with head and neck squamous cell carcinoma receiving concurrent…
Comparison of the opioid-sparing effects of a combination of dexamethasone, paracetamol, and ketorolac versus paracetamol and ketorolac in patients undergoing total laparoscopic hysterectomy: A prospective double-blind randomized controlled trial.
This prospective, double-blind randomized controlled trial compared adding intravenous dexamethasone to paracetamol and ketorolac with paracetamol and ketorolac alone in 100 women aged 18–60 years with ASA I–II status…
Drug-drug interactions between statins and antibiotics: A systematic review and meta-analysis of observational studies.
This systematic review and meta-analysis assessed observational evidence on muscle toxicity when statins are used with interacting antibiotics, compared with statin therapy alone.
Adjunctive neodymium-doped yttrium aluminum garnet laser therapy for periodontitis in type 2 diabetes: A randomized controlled trial.
This randomized controlled trial compared conventional nonsurgical periodontal therapy with or without adjunctive neodymium-doped yttrium aluminum garnet laser therapy in 120 patients with periodontitis and type 2…
Early Metformin Initiation and Glycemic Outcomes in Gestational Diabetes: A Secondary Analysis of a Randomized Clinical Trial.
This secondary analysis of a double-masked, placebo-controlled randomized clinical trial assessed early metformin versus placebo, alongside usual care, in pregnancies complicated by gestational diabetes at two Irish…
Prognostic value of Murray law-based quantitative flow ratio after percutaneous coronary intervention.
This prespecified subgroup analysis of the randomised FAVOR III China trial assessed whether post-PCI Murray law-based quantitative flow ratio (μQFR) was associated with long-term outcomes.
Full-Service Mobile Food Markets and Dietary Quality in Low-Income Housing Communities: A Randomized Clinical Trial.
This cluster randomized clinical trial evaluated weekly full-service mobile market service at 12 subsidized housing sites in the Minneapolis–St. Paul area.
Visual Perceptual Learning Based on Adaptive Contrast Detection Training Enhances Vision and Contrast Sensitivity in Diabetic Retinopathy.
This randomized controlled trial evaluated 3-month home-based visual perceptual learning (VPL) in people with diabetic retinopathy who had received routine therapies.
Leptomeningeal carcinomatosis arising from esophageal cancer: a systematic review of the literature.
This systematic review synthesized 31 studies describing 43 patients with leptomeningeal carcinomatosis arising from esophageal cancer.
Severe neuropsychiatric manifestations in a 17-year-old male with a 20p13 interstitial deletion encompassing CSNK2A1: a case report.
A 17-year-old male had a de novo interstitial 419 kb deletion at 20p13 encompassing CSNK2A1. His presentation was considered compatible with Okur-Chung neurodevelopmental syndrome, although the deletion was described as…
Acceptability of a patient support and educational intervention for black breast cancer survivors.
This clinical trial evaluated the feasibility and acceptability of a six-week group support and education intervention for English-speaking Black women who had survived stage I–III breast cancer diagnosed within the…
Sphenoidal Meningioma with Focal Seizures Masquerading as Immune Reconstitution Inflammatory Syndrome in HIV Patient.
A 47-year-old woman with HIV developed recurrent focal-onset seizures progressing to bilateral tonic-clonic seizures about 4 weeks after starting antiretroviral therapy.
Metaplastic Carcinoma of the Breast: A Rare Biphasic Tumour-case Report and Literature Review.
A 49-year-old woman presented with a chronic right breast lump that enlarged rapidly over 3 months, with weight loss and fever. Examination found a large, firm mass and ipsilateral axillary lymphadenopathy.
Breast Adenomyoepithelioma with Malignant Changes in a 36-year-old Female: Clinicopathological, Histomorphological and Therapeutic Considerations.
A woman described in the abstract as 360 years old presented with an asymptomatic left breast tumour measuring 2.5 cm × 2.0 cm × 0.8 cm.
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