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2000 articles
October 202624
Long-term impact of aficamten on patient-reported outcome measures in obstructive hypertrophic cardiomyopathy: results from FOREST-HCM.
This open-label extension study assessed longer-term patient-reported outcomes with aficamten in people with obstructive hypertrophic cardiomyopathy who had completed an aficamten trial.
POSTERIOR DISLOCATION OF POSTERIOR LAMELLAR CORNEAL GRAFT WITH VIABLE ENDOTHELIAL CELLS.
A middle-aged man with prior traumatic eye injury and pars plana vitrectomy, lensectomy, and scleral-sutured intraocular lens fixation developed corneal edema requiring Descemet stripping automated endothelial…
Treatment of Progressive Multifocal Leukoencephalopathy With Third-Party Allogeneic BK Virus T Cells.
This single-center phase 2 study evaluated third-party, partially HLA-matched BK virus-specific T cells in 37 patients with progressive multifocal leukoencephalopathy (PML), including 23 with hematologic malignancy.
Proof-of-Concept Phase 2a Trial of VH4524184: An Emerging Third-Generation Integrase Strand Transfer Inhibitor With an Enhanced Resistance Profile.
This randomized, double-blind, placebo-controlled phase 2a trial assessed short-course oral VH-184 monotherapy in adults with HIV-1 who were antiretroviral-therapy naive and had HIV-1 RNA ≥ 3000 copies/mL.
Can neurodevelopmental disorders be part of brain-lung-thyroid syndrome? A case report.
A 12-year-old girl with an NKX2-1 gene mutation was reported to have an articulation disorder and a specific learning disorder.
Real-Time Electronic Patient-Reported Outcome Monitoring With Digital Triage and Care-Team Integration in Early Breast Cancer: ENABLE Randomized Controlled Trial.
The multicenter, open-label ENABLE randomized controlled trial compared weekly electronic patient-reported outcome (ePRO) screening with rule-based triage and care-team alerts against an active app-based support…
Efficacy of a Gamified Training Program for Improving Occupational Health and Safety Knowledge Among Italian Secondary School Students: A Randomized Controlled Field Trial.
This cluster-randomized controlled field trial assessed whether a gamified occupational health and safety (OHS) program improved knowledge among Italian secondary school students.
An Elusive Diagnosis of Strongyloides Infection Masquerading as Daptomycin-Induced Eosinophilic Pneumonitis.
A middle-aged man with alcoholic cirrhosis developed peripheral eosinophilia, bilateral pulmonary nodules, migratory consolidative opacities, and pleural effusions while receiving daptomycin for polymicrobial…
Acute pericarditis caused by Kocuria kristinae with successful withdrawal from hemodialysis: a case report.
A 47-year-old man developed dialysis-dependent acute kidney injury after severe heatstroke. About a month later, imaging showed a marked increase in cardiothoracic ratio, and echocardiography demonstrated a substantial…
Immunogenicity and Safety of Coadministration of AS01E-Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine and a COVID-19 mRNA Vaccine in Adult s Aged ≥50 Years: A Phase 3, Randomized, Noninferiority Trial.
This phase 3, open-label, multicenter randomized noninferiority trial compared coadministration of an AS01E-adjuvanted RSV prefusion F vaccine and an Omicron XBB.1.5 COVID-19 mRNA vaccine with administration…
IDIOPATHIC ACUTE EXUDATIVE POLYMORPHOUS VITELLIFORM MACULOPATHY: A 5-YEAR FOLLOW-UP.
A patient with idiopathic acute exudative polymorphic vitelliform maculopathy had 20/20 visual acuity in both eyes. Examination showed symmetrical multifocal serous retinal detachments and foveal vitelliform lesions…
SARS-CoV-2 Vaccination and Attenuation of Breakthrough Infection Severity: A Systematic Global Review and Meta-analysis.
This systematic review and meta-analysis examined whether COVID-19 vaccination attenuates disease severity among people with breakthrough infections, using global observational studies reporting matched…
FLANGED INTRASCLERAL INTRAOCULAR LENS FIXATION USING 31-G NEEDLES.
A 73-year-old man with right intraocular lens (IOL) subluxation underwent flanged intrascleral IOL fixation using the double-needle technique with a 31-gauge needle.
Treatment of Crimean-Congo Hemorrhagic Fever With Supportive Care, Favipiravir, and Avatrombopag.
A patient with severe Crimean-Congo hemorrhagic fever was managed in a high-level isolation unit with supportive care, favipiravir, and avatrombopag.
Impact of Intermittent Preventive Treatment for Malaria in Pregnancy With Sulfadoxine-Pyrimethamine, Dihydroartemisinin-Piperaquine, and Their Combination on Infant Outcomes: A Randomized Controlled Trial.
This double-blind randomized controlled trial compared infant malaria and growth outcomes after maternal intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine…
MACULAR CHOROIDAL NEOVASCULARIZATION IN PERIPAPILLARY HYPERREFLECTIVE OVOID MASS-LIKE STRUCTURES: CASE REPORT.
A healthy 36-year-old woman presented with three days of vision loss in her right eye. Optical coherence tomography of the optic nerve head showed peripapillary hyperreflective ovoid mass-like structures (PHOMS), while…
Impact of Chatbot-Based Cognitive Training on Cognitive Function and White Matter Integrity in Cognitively Unimpaired Older Adults: Randomized Controlled Trial.
This single-blind randomized controlled trial evaluated chatbot-based cognitive training in 72 cognitively unimpaired older adults.
Complex cervical venous drainage with a common facial-paralaryngeal anastomosis receiving the superior thyroid vein.
A 68-year-old woman’s archived CT angiogram showed a complex right cervical venous arrangement. The common facial vein and a separate lingual–parapharyngeal–paralaryngeal channel each drained into the right internal…
Home-based nurse-led self-management support for heart failure: a randomized controlled trial.
This parallel-group randomized controlled trial assessed a 12-week, nurse-led home programme of tailored self-management support and follow-up for adults aged 40–75 years with NYHA class I–III heart failure and ejection…
Vulvar High-Grade Squamous Intraepithelial Lesion in Primary Lymphedema With Severe Genital Lymphorrhea: A Case Report.
A 37-year-old woman with childhood-onset primary lymphedema developed recurrent right leg and genital swelling after 31 years of clinical quiescence, with vulvar erythema, follicular lesions, and persistent lymphorrhea.
Efficacy and Safety of Short-Course Radiotherapy Alone or Combined With Consolidation Chemotherapy Versus Conventional Long-Course Chemoradiotherapy for Locally Advanced Rectal Cancer: A Meta-Analysis of Randomized Controlled Trials.
This meta-analysis of randomized controlled trials compared short-course radiotherapy (SCRT), with or without consolidation chemotherapy, against long-course chemoradiotherapy (LCCRT) for locally advanced rectal cancer.
Effect of photobiomodulation on recovery from oral soft tissue local anaesthesia in paediatric patients: a preliminary split-mouth randomized clinical trial.
This preliminary split-mouth randomized clinical trial assessed whether 810-nm diode laser photobiomodulation (PBM) shortened oral soft-tissue anaesthesia after infiltration local anaesthesia in 34 children aged 8–12…
Peritoneal Tuberculosis and Chronic Myeloid Leukaemia: A Case of Hickam's Dictum.
A 34-year-old man presented with persistent fever, ascites, thrombocytosis and clinical deterioration despite broad-spectrum therapy.
Efficacy and cost effectiveness of high volume injections with and without corticosteroid compared with sham for midportion Achilles tendinopathy (Inject trial): randomised controlled trial.
The Inject trial was a single-centre, participant- and assessor-masked, three-arm randomised controlled trial in 192 adults with midportion Achilles tendinopathy.
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