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2000 articles
November 202624
EMB-01, an Anti-EGFR/c-MET Bispecific Antibody, in Patients with Heavily Pretreated Metastatic Colorectal Cancer from a Phase Ib/II, Open-Label, Multicenter Study.
This phase Ib/II, open-label, multicenter study evaluated weekly intravenous EMB-01, an EGFR/c-MET bispecific antibody, in patients predominantly with heavily pretreated metastatic colorectal cancer (mCRC).
Safety, Biodistribution, and Dosimetry of FAP and Integrin α v β 3 Dual-Targeting Radioligand 177 Lu-DOTA-FAPI-RGD: Preclinical Validation and First-in-Human Study in Patients with Advanced Adenocarcinomas.
This phase I, first-in-human study evaluated the safety, biodistribution, dosimetry, and preliminary efficacy of the dual-targeting radioligand 177Lu-LNC1009 in nine patients with advanced solid tumors and positive…
Neoadjuvant concurrent or sequential anthracycline-containing chemotherapy and HER2-targeted agents for HER2-positive breast cancer: a randomized phase 2 study (METIS).
The randomized phase II METIS trial compared neoadjuvant pegylated liposomal doxorubicin (PLD)-based chemotherapy given concurrently with trastuzumab and pertuzumab against sequential epirubicin/cyclophosphamide-based…
Orthoplastic Limb Salvage Using Transtibial Transport and Free-Flap Reconstruction in Patients With Diabetes-Related Chronic Limb-Threatening Ischemia.
A 56-year-old man with poorly controlled diabetes and severe peripheral arterial disease developed a chronic foot ulcer with toe gangrene despite unsuccessful revascularization, leaving no conventional revascularization…
Early Metformin Initiation and Glycemic Outcomes in Gestational Diabetes: A Secondary Analysis of a Randomized Clinical Trial.
This secondary analysis of a double-masked, placebo-controlled randomized clinical trial assessed early metformin versus placebo, alongside usual care, in pregnancies complicated by gestational diabetes at two Irish…
Prognostic value of Murray law-based quantitative flow ratio after percutaneous coronary intervention.
This prespecified subgroup analysis of the randomised FAVOR III China trial assessed whether post-PCI Murray law-based quantitative flow ratio (μQFR) was associated with long-term outcomes.
An Exploratory Study of Image-Guided Cochlear Implant Intervention on Articulation and Phonological Processing in Children With Speech Sound Disorders.
This exploratory analysis examined articulation and phonological processing in 21 children aged 4.7–13.1 years with cochlear implants and deficits in these skills, enrolled in a 2-year waitlist-deferred randomized…
Fucoidan as an anti-inflammatory and immunomodulatory agent in humans: a systematic review of clinical evidence and translational potential.
This systematic review assessed human interventional studies of fucoidan supplementation for inflammatory, immune, metabolic, and tumour-related outcomes.
An Approach to Acute Cranial Symptoms in Primary Care: Lesson From a Case of Miller Fisher Syndrome.
A 38-year-old woman developed acute diplopia, right eye pain, headache, and perioral numbness two weeks after an upper respiratory infection.
Clinical effectiveness and safety of bacterial cellulose dressings in the management of skin wounds: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed the efficacy and safety of bacterial cellulose dressings compared with conventional treatments for skin wounds.
Low-level laser therapy in ulcerative lesions in leprosy: a systematic review.
This systematic review assessed whether low-level laser therapy (LLLT) improves healing of ulcerative lesions in people with leprosy.
Pearls & Oy-sters: The Price of Patency: Intractable Headache Subsequent to Fourth Ventricular Recanalization.
A 61-year-old woman with secondary fourth ventricular hemorrhage was treated using an IRRAflow active irrigation and drainage system.
Germline Genetic Variants and Epilepsy Surgery Response: Individual Participant Pooled Analysis of 272 Patients.
This systematic review and individual-participant pooled analysis examined seizure outcomes after resection or laser ablation in 272 people with pathogenic or likely pathogenic germline epilepsy variants, excluding…
Caring Contacts and Suicidality Among American Indian and Alaska Native Communities: A Randomized Clinical Trial.
The CARE study was a blinded, two-group randomized clinical trial of 709 American Indian and Alaska Native adults with active suicidality across five communities.
Mycobacterium abscessus bacteremia: A narrative literature review based on a case report.
The report describes a catheter-associated bloodstream infection caused by Mycobacterium abscessus subsp. massiliense. The authors also reviewed published M.
Pilot Implementation of an Adapted Online Clinic-Community Model for Childhood Obesity.
This two-arm randomized controlled trial assessed feasibility, acceptability, and preliminary effectiveness of an adapted online family-based clinic-community intervention for children aged 4 to < 8 years with…
In-the-Bag Stability of a New Hydrophilic Acrylic Toric Intraocular Lens.
This single-centre, prospective interventional clinical trial assessed in-the-bag stability of the RayOne EMV toric intraocular lens in 119 eyes of 79 patients with age-related cataract over 6 months.
Emergency management of obturator hernıa in elderly patients: A case series and surgical strategy.
Three elderly, cachectic women presented with symptoms and signs of mechanical intestinal obstruction. CT imaging identified obturator hernias, and all underwent emergency surgery.
European Guidelines on Multidisciplinary Management of Obstructed Defecation Syndrome-ESCP, UEG, ESGAR, EAGEN, ESGENA, ESNM and ESPCG.
These European multidisciplinary practice guidelines address diagnosis and management of obstructed defecation syndrome (ODS).
LEgal Guidance for Cancer Patients and CAREgivers (LEGACY CARE): A Pilot Clinical Trial.
This single-arm pilot clinical trial evaluated the feasibility and acceptability of proactive legal care for patient-caregiver dyads affected by advanced-stage colorectal cancer.
Father-Daughter Autosomal Recessive Gitelman Syndrome Caused by Compound Heterozygous Variants in the SLC12A3 Gene.
A Chinese father and daughter were found to have Gitelman syndrome, a kidney tubular disorder associated with pathogenic SLC12A3 variants.
Recurrent Cardiac Cephalalgia: A Case Report and Pooled Narrative Review.
An elderly man with multiple cardiovascular risk factors and prior coronary artery disease treated with percutaneous coronary intervention had progressive exertional headaches over several years, without typical cardiac…
A rare injury combination: Hawkins type I talar neck fracture, Jones fracture, and calcaneal avulsion fracture accompanying a bimalleolar ankle fracture.
A patient with a bimalleolar ankle fracture also had a Jones fracture, a Hawkins type I talar neck fracture, and a calcaneal avulsion fracture.
Phase 1 Evaluation of the Pharmacokinetics of Sevasemten (EDG-5506) for Potential Food Effect and Drug-Drug Interaction With a CYP3A4 Moderate Inhibitor.
This Phase 1, open-label, parallel study assessed the pharmacokinetics of sevasemten in healthy subjects across three cohorts: sevasemten alone while fasted, with verapamil, and after a high-fat meal.
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