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2000 articles
November 202624
Proton-pump inhibitor-induced severe hypomagnesemia presenting with seizure and functional hypoparathyroidism: A diagnostic challenge in long-term acid suppression therapy.
A 68-year-old man taking omeprazole 40 mg/day for 8 years presented with a generalized tonic-clonic seizure and neuromuscular irritability.
Leptomeningeal carcinomatosis arising from esophageal cancer: a systematic review of the literature.
This systematic review synthesized 31 studies describing 43 patients with leptomeningeal carcinomatosis arising from esophageal cancer.
Severe neuropsychiatric manifestations in a 17-year-old male with a 20p13 interstitial deletion encompassing CSNK2A1: a case report.
A 17-year-old male had a de novo interstitial 419 kb deletion at 20p13 encompassing CSNK2A1. His presentation was considered compatible with Okur-Chung neurodevelopmental syndrome, although the deletion was described as…
A Phase II Trial of Pembrolizumab plus Granulocyte-Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer.
This single-center phase II trial evaluated pembrolizumab plus GM-CSF in 42 patients with advanced biliary cancers previously treated with chemotherapy and without prior immune checkpoint inhibitor therapy.
Metaplastic Carcinoma of the Breast: A Rare Biphasic Tumour-case Report and Literature Review.
A 49-year-old woman presented with a chronic right breast lump that enlarged rapidly over 3 months, with weight loss and fever. Examination found a large, firm mass and ipsilateral axillary lymphadenopathy.
Role of magnesium as a protective agent in cisplatin-induced nephrotoxicity in head and neck cancer.
This randomized controlled trial evaluated intravenous magnesium sulfate for prevention of cisplatin-induced nephrotoxicity in 100 newly diagnosed patients with head and neck squamous cell carcinoma receiving concurrent…
Proteomic and Metabolomic Profiling in Moyamoya Disease: A Systematic Review.
This systematic review examined human studies using high-throughput proteomic or metabolomic methods on serum or cerebrospinal fluid in Moyamoya disease (MMD). Of 3,071 records identified, 31 studies were included.
Effects of Vitamin D 3 Supplementation on Glycaemic Parameters and Insulin Sensitivity in Pre-diabetic Adults: A Prospective Controlled Interventional Study.
This prospective controlled interventional study assessed daily oral vitamin D3 alongside lifestyle advice in 90 pre-diabetic adults aged 18–65 years in Chennai, compared with lifestyle advice alone.
Neoadjuvant PD-L1/TGF-β blockade can rapidly disrupt the tumor stroma in head and neck cancer patients.
This window-of-opportunity clinical study examined neoadjuvant bintrafusp alfa, a dual PD-L1 and TGF-β inhibitor, in patients with head and neck squamous cell carcinoma.
Dual Inhibition of LAG-3 and PD-1 with IBI110 and Sintilimab in Advanced Alveolar Soft Part Sarcoma: A Single-Center, Phase II Trial.
This open-label, single-center phase II trial evaluated IBI110 plus sintilimab in 28 patients with advanced alveolar soft part sarcoma (ASPS), including patients who were naïve or resistant to prior immune checkpoint…
Short-term bioavailability of EPA and DHA from an algae oil-fortified soymilk compared with algae oil capsules.
This 4-week, open-label, randomized parallel trial compared short-term EPA and DHA bioavailability from algae oil-fortified soymilk with algae oil capsules in 21 healthy adults.
Effects of Dual-Task Training With and Without Backward Walking on Balance, Functional Mobility, and Participation in Ambulatory Children With Spastic Diplegic Cerebral Palsy: A Randomized Controlled Trial.
This randomized controlled trial compared dual-task training (DTT) with DTT incorporating backward walking (BW) in 44 ambulatory children aged 6–12 years with spastic diplegic cerebral palsy (GMFCS I–II).
Extended Follow-up of Botensilimab plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer without Active Liver Metastases.
This phase Ib clinical trial evaluated botensilimab plus balstilimab in patients with previously treated microsatellite-stable metastatic colorectal cancer without active liver metastases.
Conservative Management of Presumptive Free Flap Pedicle Compromise on Postoperative Day 6: Report of Two Cases and Literature Review.
Two patients underwent lower-extremity free-flap reconstruction for exposed tibial bone or hardware. On postoperative day 6, both developed loss of Doppler signal and clinical ischemia, raising concern for late pedicle…
Fascial Patch Reconstruction of a Gastric Conduit Defect Using an Anterolateral Thigh-Vastus Lateralis Composite Free Flap: A Case Report.
A 71-year-old man with a retrosternal gastric conduit developed a full-thickness rupture during coronary artery bypass grafting through median sternotomy.
Comparison of Traumatic Complications following Prostate Biopsy in Men with Lower Urinary Tract Symptoms Due to Prostate Disease Using Biopty Gun versus Semiautomatic Needle.
This randomised comparative study assessed pain and bleeding after digitally guided transrectal prostate biopsy using a semiautomatic needle or a fully automatic biopty gun in 64 men with lower urinary tract symptoms…
Clinical Reasoning: An 18-Year-Old Woman With Episodic Stiffness, Exercise Intolerance, and Weakness: Decoding a Neuromuscular Mystery.
An 18-year-old woman had longstanding episodic muscle stiffness, cold sensitivity, exercise intolerance, and stable proximal weakness.
Effect of Blonanserin on Neurotrophic Factors in Patients With Non-Responsive First-Episode Schizophrenia Treated With Early Risperidone Monotherapy-A Randomized Controlled Trial.
This randomized controlled trial compared blonanserin with clozapine over 3 months in 120 hospitalized patients with first-episode schizophrenia who had not responded to early risperidone monotherapy.
Randomized Single-Masked Study of Preservative-Free Versus Preserved Hyaluronic Acid in Dry Eye Disease.
This randomized, single-masked, 6-month trial compared preservative-free hyaluronic acid (PF HA) with benzalkonium chloride-preserved hyaluronic acid (BAK HA) in 47 patients with dry eye disease; 43 completed the study.
Dapagliflozin attenuates progression from prefrailty to frailty in patients with hypertension and chronic kidney disease.
DAPA-FORTRESS followed prefrail hypertensive adults aged over 65 years with chronic kidney disease (CKD) for 1 year to examine links between renal measures and physical performance, and whether dapagliflozin was…
Drug-drug interactions between statins and antibiotics: A systematic review and meta-analysis of observational studies.
This systematic review and meta-analysis assessed observational evidence on muscle toxicity when statins are used with interacting antibiotics, compared with statin therapy alone.
Ethnoracial and Linguistic Diversity in Treatment Research for Primary Progressive Aphasia: A Systematic Review.
This systematic review examined ethnoracial, linguistic, and social-determinant representation in nonpharmacological intervention research for people with primary progressive aphasia (PPA) or primary progressive apraxia…
Persistent Amotivation After Cannabis-Related Psychosis: Diagnostic Challenges and Clinical Course With Electroconvulsive Therapy: A Case Report.
A 19-year-old man developed auditory hallucinations, persecutory delusions, and agitation associated with cannabis use. Antipsychotic treatment improved the psychosis, but marked amotivation and inactivity persisted…
A Phase I First-Time-in-Human, Open-label Study of Nelistotug Administered to Patients with Advanced Solid Tumors.
This first-in-human, open-label, nonrandomized, multicenter phase I study evaluated nelistotug, an anti-CD96 antibody, alone or with dostarlimab, and in a three-drug combination with dostarlimab and belrestotug in…
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