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2000 articles

October 202624

Clinical ResearchPediatricsOpen access

Daily Zinc Supplementation for Infection Prevention in Children With Sickle Cell Anemia: The ZIPS-2 Randomized Clinical Trial.

The ZIPS-2 randomized, double-blind, placebo-controlled trial evaluated daily zinc for infection prevention in children aged 1 to 4.99 years with sickle cell anemia in Uganda.

JAMAOct 13, 2026Read summary
Clinical ResearchCardiologyOpen access

Cold and Room-Temperature Platelets in Cardiac Surgery: The CHIPS Randomized Clinical Trial.

The phase 3, multicenter, randomized CHIPS trial compared cold-stored platelets (CSPs; up to 21 days) with room-temperature platelets (RTPs; up to 7 days) in pediatric and adult patients receiving platelet transfusions…

JAMAOct 13, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Elinzanetant in postmenopausal women with sleep disturbance: results from the randomized, phase II NIRVANA study.

The phase II NIRVANA randomised trial assessed elinzanetant versus placebo in 110 postmenopausal women aged 40–65 years with moderate-to-severe vasomotor symptoms and objectively measured sleep disturbance.

SleepOct 13, 2026Read summary
Clinical ResearchGeriatrics

Feasibility of Online and On-Site Physical Activity Delivery Among Older Adults: Mixed Methods Pilot Randomized Controlled Trial.

This unblinded, site-cluster-randomized mixed methods pilot trial assessed the feasibility of a 26-week Otago physical activity program delivered online or in person to community-dwelling adults aged 60 years or older…

JMIR Form ResOct 13, 2026Read summary
Clinical ResearchGeriatrics

Effects of aquatic and land-based resistance training on hip bone health in overweight older women: A 32-week randomized controlled trial.

This secondary analysis of a six-arm randomized controlled trial compared supervised aquatic and land-based elastic resistance training with control in 98 older women with overweight.

Arch Gerontol GeriatrOct 13, 2026Read summary
Case ReportPathology (Anatomic & Clinical)Open access

Atypical presacral masses in Currarino syndrome: a case series.

The report describes three patients with Currarino syndrome, a congenital condition involving a sacral anomaly, anorectal malformation, and presacral mass.

Childs Nerv SystOct 13, 2026Read case
Case ReportAnesthesiology

Successful Kidney Transplantation Under Combined Spinal-Epidural Anesthesia in a Patient With a History of Left Pneumonectomy Due to Bronchiectasis.

A 33-year-old man with end-stage kidney disease from biopsy-proven AA amyloidosis was assessed for preemptive living-donor kidney transplantation.

Am J Case RepOct 13, 2026Read case
Clinical ResearchDermatology

Clinical translation of polymeric microneedles for bioactive nanovesicle delivery in hypertrophic scar remodeling.

This prospective, single-center, open-label, single-arm study evaluated a 12-week protocol combining microplasma radiofrequency, poly(L-lactic acid) microneedles, and topical milk-derived bioactive nanovesicles in 26…

Biomater SciOct 13, 2026Read summary
Clinical ResearchNeurologyOpen access

Long-Term Quantitative MRI and Quality-of-Life After Endovascular Therapy in Acute Ischemic Stroke - A MR CLEAN-NO IV Substudy.

This long-term substudy of the MR CLEAN-NO IV randomised trial examined quantitative MRI and quality of life three years after acute ischaemic stroke.

Transl Stroke ResOct 13, 2026Read summary
Clinical ResearchNeurologyOpen access

Pharmacological and Non-Pharmacological approaches to manage Tension-Type Headache: a Systematic Review.

This systematic review assessed randomized clinical trials of pharmacological and non-pharmacological treatments for episodic or chronic tension-type headache (TTH), examining headache pain and related clinical…

Curr Pain Headache RepOct 13, 2026Read summary
Clinical ResearchUrologyOpen access

Opioid-free versus opioid-based anesthesia for robot-assisted radical prostatectomy: a single-center randomized controlled trial.

This single-center randomized controlled trial compared opioid-free anesthesia (dexmedetomidine plus ketamine) with remifentanil-based anesthesia in adult men undergoing robot-assisted radical prostatectomy.

J Robot SurgOct 13, 2026Read summary
Clinical ResearchCardiologyOpen access

Fibro-Inflammatory Signaling, Fibrosis, and Microvascular Ischemia as Convergent Translational Substrates of Sudden Cardiac Death in Hypertrophic Cardiomyopathy: A Systematic Review.

This systematic translational review examined whether fibro-inflammatory signaling, fibrosis, and microvascular ischemia converge as substrates for ventricular arrhythmia and sudden cardiac death in hypertrophic…

J Cardiovasc Transl ResOct 13, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Six-month supervised telerehabilitation combining pilates-based therapeutic exercise and self-myofascial release in adults with fibromyalgia: a randomized controlled trial.

This two-arm randomized controlled trial evaluated a six-month supervised home-based telerehabilitation programme in 68 adults with fibromyalgia confirmed by 2016 ACR criteria.

J Rehabil MedOct 13, 2026Read summary
Clinical ResearchInfectious Diseases

The dual burden of disease: Depression among patients with multidrug resistance tuberculosis in low-income and lower- middle-income countries: A systematic review and meta-analysis.

This systematic review and random-effects meta-analysis estimated depression prevalence and examined associated factors among patients with multidrug-resistant tuberculosis (MDR-TB) in low- and lower-middle-income…

PLoS OneOct 13, 2026Read summary
Clinical ResearchOphthalmology

USB-powered vs. self-heating warm compresses for meibomian gland dysfunction: A prospective randomized crossover clinical trial.

This prospective randomized crossover trial compared USB-powered and self-heating warm compresses in 15 adults aged 18–40 years with meibomian gland dysfunction and tear break-up time ≤10 s.

PLoS OneOct 13, 2026Read summary
Case ReportCardiology

Life-Threatening Ventricular Tachycardia and Transient Brugada-Like Electrocardiographic Abnormalities Caused by Severe Hyperkalemia Due to Urinary Retention in a 55-Year-Old Man.

A 55-year-old man without known cardiovascular disease presented with palpitations, dyspnea, and diaphoresis, then developed hemodynamically unstable sustained wide-QRS ventricular tachycardia with recurrent episodes…

Am J Case RepOct 13, 2026Read case
Clinical ResearchNephrology

Haemodiafiltration, haemofiltration and haemodialysis for adults with kidney failure.

This Cochrane systematic review and meta-analysis assessed randomised trials comparing convective dialysis (haemofiltration, haemodiafiltration or acetate-free biofiltration) with diffusive haemodialysis or expanded…

Cochrane Database Syst RevOct 13, 2026Read summary
Clinical ResearchPediatrics

Prevalence and genotype distribution of norovirus and rotavirus among children under five with diarrheal infection in lower-middle-income countries after Rotavirus vaccine introduction: A systematic review and meta-analysis.

This systematic review and meta-analysis assessed norovirus and rotavirus prevalence and genotype distribution among children under five with diarrheal infection in low- and middle-income countries after rotavirus…

PLoS OneOct 13, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Refining Home-Based Squat Training: The Role of Hip Adduction in Improving Neuromuscular Control for Clinically Diagnosed Patellofemoral Pain Syndrome.

This randomized controlled trial compared an 8-week home-based squat program with and without hip adduction in 30 participants with clinically diagnosed patellofemoral pain syndrome (PFPS); both groups also performed…

Med Sci MonitOct 13, 2026Read summary
Clinical ResearchPediatrics

Cost comparison of the ShangRing device versus Mogen clamp for early infant male circumcision in Sub-Saharan Africa.

This cost comparison alongside a randomized controlled trial assessed early infant male circumcision using the ShangRing (SR) versus the Mogen clamp (MoC) among infants aged 0–60 days in Kenya, Tanzania, and Uganda.

PLoS OneOct 13, 2026Read summary
Case ReportNeurosurgery

Conus Medullaris Syndrome Following Traumatic Thoracolumbar Burst Fractures: Clinical Presentation, Surgical Management, and Early Outcomes in Three Cases.

Three patients with traumatic thoracolumbar burst fractures had conus medullaris syndrome with differing neurological presentations.

Ann Afr MedOct 13, 2026Read case
Clinical ResearchPulmonology

Effectiveness of a fully digital mandibular advancement appliance compared with CPAP in the treatment of obstructive sleep apnea.

This crossover clinical study compared a fully digital mandibular advancement appliance (MAA) with CPAP in 20 adults with obstructive sleep apnea (OSA), confirmed by polysomnography and non-adherent to CPAP.

Dental Press J OrthodOct 12, 2026Read summary
Case ReportInfectious Diseases

Brought with the wind: A case of melioidosis acquired in the United States presenting with multiple pulmonary nodules.

A Florida resident without recent international travel presented with fever, pleuritic chest pain, and hypoxia after severe weather.

PLoS Negl Trop DisOct 12, 2026Read case
Case ReportNeurology

The Effects of Multimodal Communication Treatment With Discourse and Group Activities via Telepractice on People With Severe Nonfluent Aphasia: A Case Study.

Two people with severe nonfluent aphasia—one with Broca’s aphasia and one with global aphasia—received 10 weeks of telepractice multimodal communication treatment.

Am J Speech Lang PatholOct 12, 2026Read case

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