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2000 articles
October 202624
Individualized multimodal pain management for chronic perineal pain: A case report.
A 68-year-old woman had three years of chronic perineal pain and tenderness that disrupted sleep, urination, and daily activities.
Rare origin of the right inferior phrenic artery from the anterior inferior pancreaticoduodenal artery in a patient with hepatocellular carcinoma.
A woman in her 80s with ruptured hepatocellular carcinoma underwent emergency transcatheter arterial embolization. CT did not show the right inferior phrenic artery (RIPA) at its usual origins and suggested a source in…
Iptacopan combined with immunosuppressive therapy for aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome: A case report.
A previously healthy 24-year-old man presented with dizziness, fatigue, and pancytopenia. Bone marrow examination supported aplastic anemia, with a PNH clone also identified.
Artificial intelligence-enhanced electrocardiography for predicting mortality and major adverse cardiovascular events: A systematic review and narrative synthesis.
This systematic review and narrative synthesis evaluated AI-enabled 12-lead or single-lead ECG models for predicting all-cause mortality, cardiovascular mortality, and major adverse cardiovascular events in adults.
A case of neonatal gastric perforation misdiagnosed as neonatal necrotizing enterocolitis: A literature review.
A male infant born at 33 weeks and 5 days presented on day four of life with abdominal distension, feeding refusal, and no passage of flatus or stool.
Evaluating Long-Term Effectiveness and Safety of Glaucoma Surgical Innovations: A Systematic Review.
This systematic review assessed long-term effectiveness, safety reporting, and study quality for glaucoma surgical innovations introduced since 2004.
Effectiveness of Discrete Strategies and Implementation Bundles for Improving Clinician Prescription of Clinical Practice Guideline-Recommended Medications for Atherosclerotic Occlusive Disease: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed randomized trials of strategies to improve prescription of guideline-strongly-recommended medications for adults with atherosclerotic occlusive disease.
Dapagliflozin After Transcatheter Aortic Valve Implantation According to Frailty in DapaTAVI Trial.
This post hoc analysis of the multicenter randomized DapaTAVI trial examined whether frailty modified dapagliflozin’s effects after transcatheter aortic valve implantation.
Psychological Stress and the Diurnal Patterns of Sodium Excretion and Blood Pressure: Results From the SABRE Study.
The SABRE study examined whether urinary sodium responses to mental stress were associated with day–night sodium excretion patterns and systolic blood pressure (BP) dipping in apparently healthy adults.
Global Prevalence of Adherence to Antihypertensives and Associated Moderating Factors Among Adults With Hypertension: A Meta-Analysis.
This systematic review and meta-analysis estimated global adherence to antihypertensive medication among adults with hypertension.
Planned Antihypertensive Deprescribing in Long-Term Care Residents: A Systematic Review of Randomized Evidence.
This systematic review synthesized randomized and cluster-randomized studies of planned antihypertensive deprescribing among long-term care residents.
Optimal exercise modalities and doses for blood pressure management in adults with prehypertension and hypertension: A systematic review and Bayesian network meta-analysis.
This systematic review and Bayesian network meta-analysis compared structured exercise modalities and estimated doses for blood pressure reduction in adults with prehypertension or stage 1 or 2 hypertension.
Presumed oxaliplatin-related Guillain-Barré syndrome: A case report and review of chemotherapy-related Guillain-Barré syndrome.
A 77-year-old woman with metastatic cholangiocarcinoma and colorectal carcinoma developed rapidly progressive, symmetric ascending motor weakness about 2 weeks after her last cycle of gemcitabine, oxaliplatin…
The effects of multiregional fascial mobilization on heart rate and physiological parameters in patients with obstructive sleep apnea: A randomized controlled trial.
This randomized controlled trial assessed the acute physiological effects of a 16-minute multiregional fascial mobilization protocol in 95 men with polysomnography-confirmed moderate-to-severe obstructive sleep apnea.
Effectiveness of traditional mind-body exercises on fall risk test scores and balance in older adults: A systematic review and meta-analysis.
This systematic review and meta-analysis pooled 31 randomized controlled trials involving 3,622 older adults to assess traditional mind-body exercises and fall-risk test scores and balance.
AI-Assisted Molecular Review Refines SMO Inhibitor Candidacy in SHH Medulloblastoma.
A 40-year-old woman with unresectable SHH-activated medulloblastoma received standard chemoradiation, but post-treatment imaging was equivocal.
Peritoneal catheter fixation versus nonfixation in open surgery: A meta-analysis.
This meta-analysis compared fixation with nonfixation of peritoneal dialysis (PD) catheters placed by open surgery. Thirteen studies included 648 patients in the fixation group and 627 in the nonfixation group.
Akkermansia muciniphila attenuates macrophage efferocytosis to enhance anti-PD-1 efficacy in microsatellite-stable colorectal cancer.
This study examined whether Akkermansia muciniphila (Akk) could improve anti-PD-1 activity in microsatellite-stable (MSS) colorectal cancer.
Feasibility and Activity of Concurrent Neoadjuvant Chemotherapy and Radiotherapy in Patients with High-risk Soft-Tissue Sarcoma.
This analysis of the international, randomized phase III ISG-STS 1001 trial assessed concurrent epirubicin–ifosfamide chemotherapy (EI) and radiotherapy in patients with localized, high-risk soft-tissue sarcoma.
Circulating Thymidine Kinase Activity Predicts Survival and Optimal Treatment Sequencing in BRAF-Mutated Metastatic Melanoma in the SECOMBIT Trial.
This randomized phase II trial biomarker analysis evaluated circulating thymidine kinase activity (TKa) in patients with BRAF V600-mutated metastatic melanoma receiving targeted therapy (TT), immune checkpoint…
Phase I Trial of IL13Rα2-Targeted CAR T-cell Therapy for Recurrent Malignant Glioma: Clinical Results and Pharmacokinetics.
This single-centre, open-label phase I trial assessed intravenous autologous IL13Rα2-targeted CAR T cells in adults with recurrent, IL13Rα2-expressing grade 3–4 gliomas after standard treatment.
Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial.
This multicenter, phase I trial evaluated multiantigen stimulated cell therapy I (MASCT-I), alone or with ifosfamide, as first-line maintenance therapy in 31 patients with advanced sarcoma whose disease was controlled…
Phase II Trial of First-line Axitinib plus Nivolumab in Patients with Advanced Mucosal Melanoma.
This single-center, investigator-initiated phase II trial evaluated first-line nivolumab plus axitinib in patients with untreated unresectable or metastatic mucosal melanoma.
FDA Approval Summary: Erdafitinib for FGFR3-Altered Locally Advanced or Metastatic Urothelial Carcinoma.
This FDA approval summary describes evidence supporting erdafitinib for patients with FGFR3-altered locally advanced or metastatic urothelial carcinoma that progressed during or after at least one systemic therapy.
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