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2000 articles

October 202624

Case ReportDermatologyOpen access

Inherited epidermal differentiation disorders (EDD) in pediatric patients from a single Italian referral Center.

A retrospective review at an Italian referral center described three children with congenital, clinically heterogeneous inherited epidermal differentiation disorders.

Eur J PediatrOct 21, 2026Read case
Clinical ResearchOncology (Medical)Open access

Feasibility and safety of an exercise-based prehabilitation intervention before cancer surgery: a pilot randomised controlled trial.

This single-centre pilot randomised controlled trial assessed the feasibility and safety of supervised aerobic prehabilitation before surgery in patients with breast, colorectal, or prostate cancer.

Support Care CancerOct 21, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Systematic review and meta-analysis of mesh versus suture repairs of small umbilical hernias (≤ 2 cm).

This systematic review and meta-analysis compared mesh with suture repair for small umbilical hernias (defects ≤ 2 cm). The primary outcome was postoperative recurrence; secondary outcomes included complications and…

HerniaOct 21, 2026Read summary
Clinical ResearchPediatricsOpen access

Parent-child discrepancies in health-related quality of life in pediatric celiac disease: a systematic review and meta-analysis.

This systematic review and meta-analysis examined child–parent differences in health-related quality of life (HRQoL) among children and adolescents with celiac disease, using the disease-specific CDDUX questionnaire.

Eur J PediatrOct 21, 2026Read summary
Case ReportDermatologyOpen access

Blood, ink, and flies: A case report on the house fly (Musca domestica) feeding on active tattooing wounds.

During a tattoo session, a healthy 32-year-old man in Germany experienced repeated landing and feeding attempts by house flies on freshly wounded skin of his right lower leg.

Parasitol ResOct 21, 2026Read case
Clinical ResearchInfectious DiseasesOpen access

Sevuparin in children with severe malaria: a phase I safety and dose-finding trial.

This phase I dose-finding trial assessed sevuparin safety and tolerability in Kenyan and Zambian children with severe malaria.

Nat CommunOct 21, 2026Read summary
Clinical ResearchNeurologyOpen access

Real-world safety and efficacy of lecanemab in the treatment of Alzheimer's disease: a systematic review and meta-analysis.

This systematic review and meta-analysis pooled real-world studies of lecanemab treatment in people with Alzheimer’s disease, including 37 studies.

J NeurolOct 21, 2026Read summary
Clinical ResearchOncology (Medical)

The prognostic value of physical functioning on survival in patients with nonsmall cell lung cancer: a systematic review and meta-analysis.

This systematic review and meta-analysis examined whether objectively measured physical functioning predicts survival in adults with nonsmall cell lung cancer (NSCLC), across surgical and nonsurgical treatment groups.

Eur Respir RevOct 21, 2026Read summary
Clinical ResearchGeriatricsOpen access

Feasibility of a multidimensional interdisciplinary rehabilitation program for people with dementia and their informal primary caregivers - a randomized pilot trial with a caregiver focus.

This randomized pilot trial assessed the feasibility of a person-centred, interdisciplinary rehabilitation program for community-dwelling people with dementia that also provided education and support to informal…

BMC GeriatrOct 21, 2026Read summary
Clinical ResearchGastroenterology

Acetic acid chromoendoscopy for detection of neoplastic Barrett's oesophagus: stepped wedge cluster randomised controlled trial (ACID-trial).

This prospective, open-label, stepped-wedge cluster randomised trial assessed whether acetic acid chromoendoscopy (AAC) improved detection of dysplasia or oesophageal adenocarcinoma during Barrett’s oesophagus…

BMJOct 21, 2026Read summary
Clinical ResearchEmergency Medicine

A multifaceted intervention to increase bystander CPR rates after out-of-hospital cardiac arrest in France: a stepped-wedge, cluster-randomised, controlled trial.

This stepped-wedge, cluster-randomised controlled trial assessed a coordinated intervention to increase bystander CPR before EMS arrival among adults with non-traumatic out-of-hospital cardiac arrest in France.

Lancet Public HealthOct 21, 2026Read summary
Case ReportCardiology

Spiked Helmet Sign in the Early Post-Heart Transplantation Period: A Dramatic STEMI Mimic in a Structurally Normal Donor Heart.

A 36-year-old woman with severe dilated cardiomyopathy underwent heart transplantation and subsequently developed subarachnoid hemorrhage and septic shock.

Ann Noninvasive ElectrocardiolOct 21, 2026Read case
Case ReportGeneral Surgery

Duplicated Appendix With Mucocele Mimicking an Appendiceal Neoplasm in a 45-Year-Old Woman: A Case Report.

A 45-year-old woman with right lower-quadrant pain and fever had CT evidence of ruptured appendicitis with a loculated peri-appendiceal abscess, which improved after percutaneous drainage and intravenous antibiotics.

Am J Case RepOct 21, 2026Read case
Clinical ResearchObstetrics & Gynecology

Outcomes of Mindful Mood Balance for Moms, online mindfulness-based cognitive therapy for perinatal depressive relapse prevention in the USA: a two-arm, single-blind, pragmatic randomised clinical trial.

This single-blind, pragmatic randomised clinical trial tested a web-based mindfulness-based cognitive therapy programme plus usual care against usual care alone in euthymic pregnant women with recurrent depression and…

Lancet Public HealthOct 21, 2026Read summary
Clinical ResearchPulmonology

Interventions to increase participation in lung cancer screening programmes: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed interventions to improve informed choice and participation in low-dose CT lung cancer screening.

Eur Respir RevOct 21, 2026Read summary
Clinical ResearchPsychiatry

"The Effect of Forgiveness Psychoeducation on Death Anxiety, Caregiver Burden, and Forgiveness Tendencies in Caregivers of Patients at the End of Life: A Randomized Controlled Trial": Şahin 49(3) May/June 2026.

This randomized controlled trial evaluated forgiveness psychoeducation for 56 caregivers of patients at the end of life, with 28 assigned to the intervention and 28 to a no-intervention control group.

Cancer NursOct 21, 2026Read summary
Case ReportOphthalmologyOpen access

Natural History and Therapeutic Response in Ophthalmic Plasminogen Deficiency: Two Cases and Call for Registry-Based Data.

The report describes two patients with type 1 plasminogen deficiency and ligneous conjunctivitis. A 65-year-old woman with untreated disease had recurrent conjunctivitis, ultimately requiring enucleation, and developed…

Int J Mol SciOct 21, 2026Read case
Case ReportCardiology

Aspiration Thrombectomy for High-Risk Pulmonary Embolism With Life-Threatening Anemia and Active Uterine Bleeding: A Case Report.

A 48-year-old woman presented with shock, critical anemia (hemoglobin 41 g/L), and ongoing uterine bleeding associated with adenomyosis.

Am J Case RepOct 21, 2026Read case
Case ReportDermatology

5-Aminolevulinic acid-based photodynamic therapy used as a long-term management approach for refractory lichen sclerosus.

A 37-year-old man with more than 10 years of genital lichen sclerosus had recurrence after surgical resection, which left permanent anatomical deformity.

J Dermatolog TreatOct 21, 2026Read case
Clinical ResearchPreventive Medicine / Public HealthOpen access

Evaluating a multi-vaccine respiratory immunization strategy involving SARS-CoV-2, pneumococcal, and influenza vaccines in adults: A randomized, open-label, multicenter, controlled, non-inferiority Phase IV trial in China.

This randomized, open-label, multicenter Phase IV trial in China assessed immunogenicity and safety when adults aged ≥18 years received an inactivated SARS-CoV-2 vaccine with PPV23 and IIV4, compared with separate…

Hum Vaccin ImmunotherOct 21, 2026Read summary
Clinical ResearchPediatrics

Phase 2 trial to evaluate the safety and immunogenicity of a 25-valent pneumococcal conjugate vaccine (IVT-PCV25) in infants.

This double-blind, randomised phase 2 trial in 421 healthy infants in the Philippines compared three dose-ranging formulations of the 25-valent pneumococcal conjugate vaccine IVT-PCV25 with licensed Prevnar-20.

VaccineOct 21, 2026Read summary
Clinical ResearchEndocrinology

From Alert to Action: Electronic Practice Advisory Improves DSMES Referrals Over 18 Months.

This cluster-randomized controlled trial in primary care practices in central North Carolina tested whether an electronic health record best practice advisory (BPA) increased referrals to diabetes self-management…

Diabetes CareOct 21, 2026Read summary
Clinical ResearchCardiologyOpen access

Effectiveness and safety of atorvastatin/ ezetimibe fixed-dose combination in hypercholesterolemia: a systematic review and network meta-analysis.

This systematic review and network meta-analysis compared atorvastatin alone with atorvastatin/ezetimibe free-equivalent and fixed-dose combinations in people with hypercholesterolemia.

PeerJOct 21, 2026Read summary
Clinical ResearchEndocrinology

Weight loss during intermittent fasting, not Mediterranean diet quality alone, is associated with lower inflammation: A randomized controlled trial.

This 16-week randomized controlled-feeding trial studied 53 adults with metabolic risk factors assigned to a provided Mediterranean diet or their habitual western diet, with twice-weekly fasting added after 8 weeks.

Cell MetabOct 21, 2026Read summary

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