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2000 articles
October 202624
Efficacy and safety of icotrokinra for plaque psoriasis: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed icotrokinra, an oral IL-23 receptor antagonist, in adolescents and adults with moderate-to-severe plaque psoriasis.
Revascularization in Asymptomatic Carotid Artery Stenosis With Hemodynamic Impairment and Cognitive Outcomes: The CREST-H Substudy of the CREST-2 Randomized Clinical Trial.
This multicenter substudy of a phase 3 randomized clinical trial examined whether baseline cerebral hemodynamic impairment modified cognitive outcomes after carotid revascularization in adults with high-grade…
Long-term remission of severe psoriasis following CD19-directed chimeric antigen receptor T-cell therapy for follicular lymphoma.
A 60-year-old woman with a 49-year history of severe plaque psoriasis received autologous CD19-directed CAR-T therapy for follicular lymphoma.
Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial.
This multicentre, double-blind, randomised, placebo-controlled trial tested intrauterine mepivacaine before IUD placement in nulliparous individuals aged 18 to 31 years at 11 Swedish clinics.
Body image distress in women and men with advanced pancreatic cancer approaching death - post-hoc analyses from the MISTRAL-trial.
This post-hoc analysis of data from the MISTRAL trial examined changes in body image distress and weight worries among 125 women and men with pancreatic cancer during the six months before death.
Comparative effectiveness of three splints for rehabilitation after finger flexor tendon repair (FIRST): randomised controlled trial.
The FIRST pragmatic, multicentre randomised trial compared forearm-based long, Manchester short, and relative motion flexion mini splints for rehabilitation after primary zone 1 or 2 finger flexor tendon repair.
Robot-assisted versus open partial nephrectomy in patients with a solitary kidney: a systematic review and meta-analysis of perioperative and functional outcomes.
This systematic review and meta-analysis compared robot-assisted partial nephrectomy (RAPN) with open partial nephrectomy (OPN) for tumors in a solitary kidney.
Isolated Disturbance of Consciousness as Initial Presentation of Staphylococcus aureus Endocarditis: A Case Report With Brief Literature Review.
A man in his 50s presented with isolated disturbance of consciousness and no reported fever, although his admission temperature was 38°C.
Protein-losing enteropathy as a rare presentation of small bowel T-cell post-transplant lymphoproliferative disease.
A kidney transplant recipient developed episodic diarrhea, with initial investigations showing no bowel pathology. She later developed fluid retention associated with hypoalbuminemia, and technetium-99m human serum…
Associating liver partition and portal vein ligation for staged hepatectomy procedure versus conventional two-stage hepatectomy for colorectal liver metastasis.
This Cochrane systematic review and meta-analysis assessed ALPPS versus conventional two-stage hepatectomy in adults with colorectal liver metastases and an estimated future liver remnant below 30% of total liver…
The role of tyrosine kinase inhibitors as a post-hematopoietic stem cell transplant continuation therapy for pediatric acute leukemia: a systematic review.
This systematic review assessed tyrosine kinase inhibitors (TKIs) as continuation therapy after hematopoietic stem cell transplantation (HSCT) in children with acute leukemia.
Permissive Blood Pressure Targets in Pediatric Critical Care: The PRESSURE Randomized Clinical Trial.
The multicenter, unblinded pragmatic randomized PRESSURE trial compared a permissive mean arterial pressure (MAP) target (greater than the fifth percentile for age) with usual physician-set targets in hypotensive…
Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials.
This prespecified cognitive-outcomes analysis of the multicentre, randomised CREST-2 trials assessed patients aged 35 years or older with at least 70% asymptomatic carotid stenosis.
Cutaneous features of SDR9C7 variants in eight individuals with autosomal recessive nonsyndromic epidermal differentiation disorders.
Eight individuals with SDR9C7 variants and nonsyndromic epidermal differentiation disorders had scaling and erythema, commonly with fine scale, hyperlinear palms, and greater involvement of the extremities, particularly…
Efficacy and safety of topical versus intravenous tranexamic acid in primary total knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis pooled randomized controlled trials comparing topical with intravenous tranexamic acid (TXA) in patients undergoing primary total knee arthroplasty. Eleven trials were included.
Erector spinae plane block added to intercostal nerve block versus intercostal nerve block alone for postoperative analgesia in video-assisted thoracoscopic surgery: A randomized controlled trial.
This prospective, randomized controlled trial compared surgical intercostal nerve block (INB) alone with INB plus single-injection erector spinae plane block (ESPB) in 60 adults undergoing elective three-port…
Is resistance training effective to increase BDNF in multiple sclerosis? An updated systematic review and meta-analysis of isolated interventions.
This systematic review and meta-analysis examined whether isolated resistance training (RT) affects peripheral brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis (MS).
Disruption of the N-terminal domain in a STAT3 hyper-IgE syndrome variant causes disease by sequestering STAT3 in the cytoplasm.
A patient with a STAT3 R31Q variant presented with disseminated invasive aspergillosis involving the brain and lung, bronchiectasis, and elevated serum IgE, without nonimmune manifestations of hyper-IgE syndrome.
Evaluating treatment efficacy for Iliotibial Band Syndrome: A comparison of combined foam rolling and stretching with strengthening exercises versus strengthening alone in athletes.
This randomized controlled trial compared strengthening alone with strengthening plus foam rolling and stretching in 20 athletes with confirmed iliotibial band syndrome.
Purrble Use Among LGBTQ+ Young People With Self-Harm Experiences: Findings From a Qualitative Process Evaluation of a Randomized Controlled Trial.
This qualitative process evaluation explored how LGBTQ+ young people with self-harm experiences used and perceived Purrble, a socially assistive robot evaluated in a related randomized controlled trial.
Effectiveness of Wrist-Worn Wearable-Guided Cardiac Rehabilitation Delivered Through Fully Remote or Hybrid Programs in Patients With Cardiovascular Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis assessed randomized trials of wrist-worn wearable-guided cardiac rehabilitation delivered remotely or in hybrid formats during phase II or III rehabilitation for adults with…
Assessing stigma and perceptions of respectful care in Malawi's index case testing program: Findings from a cluster randomized controlled trial.
This cluster randomized controlled trial assessed whether enhanced stigma-reduction training improved healthcare worker (HCW) attitudes and client experiences in Malawi’s HIV index case testing program.
Measles transmission-related epidemiological parameter estimates: a systematic review and meta-analysis.
This systematic review and meta-analysis synthesized English- and French-language primary studies reporting measles transmission-related epidemiological parameters, identified through 14 May 2024.
A 58-Year-Old Woman with Abdominal Pain, Fever, and Cough.
A 58-year-old woman presented with fever, abdominal pain, and a nonproductive cough. The report describes a diagnostic evaluation using focused history, physical examination, and testing, with the differential diagnosis…
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