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2000 articles
November 202624
Liposomal irinotecan and capecitabine plus bevacizumab as second-line therapy in metastatic colorectal cancer: A multicenter, single-arm study.
This multicenter, single-arm clinical study evaluated liposomal irinotecan, capecitabine, and bevacizumab as second-line therapy in patients with metastatic colorectal cancer progressing after oxaliplatin-based…
Inferior Frontal Gyrus Alterations in Freezing of Gait in Parkinson's Disease Without Evidence for Overall Hemispheric Lateralization: A Systematic Review and Activation Likelihood Estimation Meta-Analysis.
This systematic review and activation likelihood estimation meta-analysis examined neuroimaging differences between people with Parkinson’s disease who experience freezing of gait (freezers) and those who do not.
Transcranial Pulse Stimulation in Parkinson's Disease: A Systematic Review.
This systematic review assessed clinical, neurophysiological, imaging, and safety outcomes of transcranial pulse stimulation (TPS) in adults with idiopathic Parkinson’s disease.
From Shrapnel to Stability: A Reverse Perforator Flap for Definitive Elbow Coverage Seven Decades Post-Trauma. A Case Report.
A man injured by shrapnel at age four sustained a severe right elbow fracture and complete ulnar nerve transection, leaving ankylosis and chronic dysfunction.
A rare injury combination: Hawkins type I talar neck fracture, Jones fracture, and calcaneal avulsion fracture accompanying a bimalleolar ankle fracture.
A patient with a bimalleolar ankle fracture also had a Jones fracture, a Hawkins type I talar neck fracture, and a calcaneal avulsion fracture.
Phase 1 Evaluation of the Pharmacokinetics of Sevasemten (EDG-5506) for Potential Food Effect and Drug-Drug Interaction With a CYP3A4 Moderate Inhibitor.
This Phase 1, open-label, parallel study assessed the pharmacokinetics of sevasemten in healthy subjects across three cohorts: sevasemten alone while fasted, with verapamil, and after a high-fat meal.
Transplantation of Hepatitis B Surface Antigen Positive or Viremic Kidneys: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed outcomes after transplantation of hepatitis B surface antigen-positive or viremic kidneys into non-viremic kidney transplant recipients.
Pediatric Liver Transplantation Following Donation After Circulatory Death Using Normothermic Regional Perfusion: A Novel Application.
A 15-year-old girl with fulminant hepatic failure after acetaminophen overdose underwent liver transplantation using a donation-after-circulatory-death graft recovered with thoracoabdominal normothermic regional…
Dermabond versus suture fixation for spinal cord stimulator trial lead anchoring: a randomized within-patient controlled trial.
This prospective, randomized within-patient controlled trial compared Dermabond with suture for anchoring bilateral thoracic percutaneous spinal cord stimulator trial leads in 48 adults.
Q-switched Nd:YAG Laser for Extrafacial Lichen Planus Pigmentosus: A Case Series Highlighting Outcomes and Risks.
Three patients with biopsy-proven lichen planus pigmentosus (LPP) involving facial and extrafacial sites received Q-switched neodymium:yttrium aluminum garnet laser treatment.
Intravenous lidocaine does not provide additional pain reduction beyond placebo in probable nociplastic chronic low back pain: a randomized controlled equivalence trial.
This randomized, placebo-controlled equivalence trial assessed repeated intravenous lidocaine in 84 adults with chronic non-specific low back pain and probable nociplastic pain features.
Added Value of Preoperative Contrast Enhanced Mammography in Staging of Malignant Breast Lesions (PROCEM): A Randomized Controlled Trial.
This prospective, multicenter randomized controlled trial evaluated whether preoperative contrast-enhanced mammography (CEM) adds value to standard imaging for staging early-stage breast cancer in women eligible for…
Association of Caregiver Mental Health and a Childhood Parenting Intervention in China.
This clustered randomized controlled trial tested whether caregiver mental health modified the effects of a center-based parenting intervention in 100 rural Chinese villages.
Phase 2 Trial of 89 Zr-Deferoxamine-Daratumumab for CD38-targeted Immuno-PET/CT Detection of Multiple Myeloma.
This prospective phase 2 trial compared CD38-targeted 89Zr-DFO-daratumumab immuno-PET/CT with standard-of-care 18F-FDG PET/CT in 60 participants with multiple myeloma.
Effects of CT-guided Radiofrequency Versus Microwave Ablation on Pulmonary Function in Individuals with Pulmonary Tumors: A Prospective Multicenter Randomized Trial.
This prospective, multicenter randomized trial compared short-term pulmonary function after CT-guided radiofrequency ablation (RFA) or microwave ablation (MWA) in 138 participants with pulmonary tumors.
Sleep Management and Recovery After TBI in Kids (SMART-Kids): Pilot Trial Using Melatonin.
This pilot randomized, double-blinded, placebo-controlled trial assessed early melatonin plus sleep education in children aged over 6 to 18 years hospitalized after traumatic brain injury (TBI).
Serum Insulin-Like Growth Factor-1 (IGF-1) in Parkinson's Disease: A Systematic Review and Meta-Analysis.
This systematic review and random-effects meta-analysis examined observational studies comparing serum IGF-1 in people with Parkinson’s disease (PD) and healthy controls, and studies of associations with PD symptoms.
Dexamethasone Eye Drops to Prevent Treatment-Requiring Retinopathy of Prematurity: The DROPROP Randomized Clinical Trial.
The DROPROP double-masked, multicentre randomised clinical trial tested whether topical dexamethasone could prevent progression to treatment-requiring type 1 retinopathy of prematurity (ROP) in preterm infants born…
Central Centrifugal Cicatricial Alopecia and the Use of Xtressé Nutrient Supplement: A Case Series.
The report describes two cases of central centrifugal cicatricial alopecia (CCCA), a scarring hair-loss condition that typically begins at the crown and spreads outward.
Clinical outcomes of Day-7 blastocysts: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis compared frozen Day-7 blastocyst transfers with Day-5 and Day-6 transfers.
Implementing Respiratory Illness Care Pathways in General Hospitals: A Cluster Randomized Trial.
This pragmatic, multicenter cluster-randomized trial evaluated implementation of inpatient pathways for asthma, pneumonia, and bronchiolitis in US general hospitals.
Clinical Trajectory of Late-Onset Delusional Disorder Toward Evolving Dementia With Lewy Bodies.
The report revisited four clinicopathological cases in which late-onset delusional disorder was the initial manifestation of Lewy body disease.
ChatGPT and Other Large Language Models in Inflammatory Arthritis: A Systematic Review Across Clinical Tasks.
This systematic review assessed large language model performance across clinical tasks in inflammatory arthritis. It included 18 studies spanning rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, gout…
Eltrombopag during induction chemotherapy in older patients with newly diagnosed acute myeloid leukemia is safe and reduces platelet transfusion requirements: The EPAG-2015 French Innovative Leukemia Organization phase 2 randomized trial.
The multicentre, phase 2 randomized trial EPAG-2015 evaluated eltrombopag started after induction chemotherapy in patients aged 60 years or older with newly diagnosed acute myeloid leukemia.
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